| Full name: CD3e molecule | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 916 | HGNC ID: HGNC:1674 | Ensembl Gene: ENSG00000198851 | OMIM ID: 186830 |
| Drug and gene relationship at DGIdb | |||
CD3E involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04660 | T cell receptor signaling pathway | |
| hsa05142 | Chagas disease (American trypanosomiasis) | |
| hsa05162 | Measles | |
| hsa05166 | HTLV-I infection |
Expression of CD3E:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD3E | 916 | 205456_at | 0.4363 | 0.5602 | |
| GSE20347 | CD3E | 916 | 205456_at | -0.2663 | 0.0317 | |
| GSE23400 | CD3E | 916 | 205456_at | -0.0885 | 0.1228 | |
| GSE26886 | CD3E | 916 | 205456_at | -0.2570 | 0.1252 | |
| GSE29001 | CD3E | 916 | 205456_at | -0.3374 | 0.1425 | |
| GSE38129 | CD3E | 916 | 205456_at | -0.2627 | 0.0519 | |
| GSE45670 | CD3E | 916 | 205456_at | 0.0543 | 0.5747 | |
| GSE53622 | CD3E | 916 | 32460 | -0.2895 | 0.1275 | |
| GSE53624 | CD3E | 916 | 32460 | -0.2911 | 0.0230 | |
| GSE63941 | CD3E | 916 | 205456_at | 0.0043 | 0.9785 | |
| GSE77861 | CD3E | 916 | 205456_at | -0.4045 | 0.0017 | |
| GSE97050 | CD3E | 916 | A_23_P416747 | 1.0388 | 0.1932 | |
| SRP064894 | CD3E | 916 | RNAseq | -0.3549 | 0.2656 | |
| SRP133303 | CD3E | 916 | RNAseq | -0.4921 | 0.1353 | |
| SRP159526 | CD3E | 916 | RNAseq | -1.1930 | 0.1723 | |
| SRP193095 | CD3E | 916 | RNAseq | -0.5088 | 0.0269 | |
| SRP219564 | CD3E | 916 | RNAseq | 0.3995 | 0.4529 | |
| TCGA | CD3E | 916 | RNAseq | 0.1796 | 0.3253 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CD3E expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CD3E:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD3E | 916 | 2 | 11 | 17 | |
| GSE20123 | CD3E | 916 | 2 | 11 | 17 | |
| GSE43470 | CD3E | 916 | 2 | 9 | 32 | |
| GSE46452 | CD3E | 916 | 3 | 26 | 30 | |
| GSE47630 | CD3E | 916 | 2 | 19 | 19 | |
| GSE54993 | CD3E | 916 | 10 | 0 | 60 | |
| GSE54994 | CD3E | 916 | 6 | 19 | 28 | |
| GSE60625 | CD3E | 916 | 0 | 3 | 8 | |
| GSE74703 | CD3E | 916 | 1 | 6 | 29 | |
| GSE74704 | CD3E | 916 | 1 | 7 | 12 | |
| TCGA | CD3E | 916 | 6 | 49 | 41 |
Total number of gains: 35; Total number of losses: 160; Total Number of normals: 293.
Somatic mutations of CD3E:
Generating mutation plots.
Highly correlated genes for CD3E:
Showing top 20/466 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD3E | ARHGAP9 | 0.820766 | 4 | 0 | 4 |
| CD3E | SUSD3 | 0.78666 | 4 | 0 | 4 |
| CD3E | FOXP3 | 0.780099 | 3 | 0 | 3 |
| CD3E | SNX20 | 0.764471 | 4 | 0 | 4 |
| CD3E | GPR171 | 0.749003 | 8 | 0 | 7 |
| CD3E | ETS1 | 0.730603 | 4 | 0 | 4 |
| CD3E | CD3D | 0.730095 | 10 | 0 | 7 |
| CD3E | IL2RG | 0.728562 | 11 | 0 | 9 |
| CD3E | PARP15 | 0.726019 | 6 | 0 | 5 |
| CD3E | VASH1 | 0.723852 | 3 | 0 | 3 |
| CD3E | UBASH3A | 0.711132 | 9 | 0 | 8 |
| CD3E | APBB1IP | 0.707144 | 7 | 0 | 6 |
| CD3E | POU2AF1 | 0.698807 | 3 | 0 | 3 |
| CD3E | CD6 | 0.698257 | 9 | 0 | 8 |
| CD3E | CEP85 | 0.697974 | 3 | 0 | 3 |
| CD3E | FCRL3 | 0.695676 | 5 | 0 | 4 |
| CD3E | UBA7 | 0.693097 | 3 | 0 | 3 |
| CD3E | CD96 | 0.692342 | 9 | 0 | 8 |
| CD3E | DTHD1 | 0.689866 | 3 | 0 | 3 |
| CD3E | INPP5D | 0.683277 | 8 | 0 | 8 |
For details and further investigation, click here
