| Full name: LDL receptor related protein 8 | Alias Symbol: APOER2|MCI1|LRP-8|HSZ75190 | ||
| Type: protein-coding gene | Cytoband: 1p32.3 | ||
| Entrez ID: 7804 | HGNC ID: HGNC:6700 | Ensembl Gene: ENSG00000157193 | OMIM ID: 602600 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LRP8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRP8 | 7804 | 208433_s_at | 1.5443 | 0.0547 | |
| GSE20347 | LRP8 | 7804 | 208433_s_at | 1.0201 | 0.0002 | |
| GSE23400 | LRP8 | 7804 | 208433_s_at | 0.8775 | 0.0000 | |
| GSE26886 | LRP8 | 7804 | 208433_s_at | 0.5026 | 0.0341 | |
| GSE29001 | LRP8 | 7804 | 208433_s_at | 0.8803 | 0.0026 | |
| GSE38129 | LRP8 | 7804 | 208433_s_at | 1.3606 | 0.0000 | |
| GSE45670 | LRP8 | 7804 | 205282_at | 1.2893 | 0.0000 | |
| GSE63941 | LRP8 | 7804 | 205282_at | -0.1365 | 0.8886 | |
| GSE77861 | LRP8 | 7804 | 208433_s_at | 0.6191 | 0.1478 | |
| GSE97050 | LRP8 | 7804 | A_23_P200222 | 0.9394 | 0.0866 | |
| SRP007169 | LRP8 | 7804 | RNAseq | 2.3052 | 0.0000 | |
| SRP008496 | LRP8 | 7804 | RNAseq | 2.0405 | 0.0000 | |
| SRP064894 | LRP8 | 7804 | RNAseq | 0.9650 | 0.0036 | |
| SRP133303 | LRP8 | 7804 | RNAseq | 1.2913 | 0.0001 | |
| SRP159526 | LRP8 | 7804 | RNAseq | 1.5150 | 0.0002 | |
| SRP193095 | LRP8 | 7804 | RNAseq | 1.5618 | 0.0000 | |
| SRP219564 | LRP8 | 7804 | RNAseq | 1.3755 | 0.0855 | |
| TCGA | LRP8 | 7804 | RNAseq | 1.1657 | 0.0000 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by LRP8 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of LRP8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRP8 | 7804 | 3 | 4 | 23 | |
| GSE20123 | LRP8 | 7804 | 3 | 3 | 24 | |
| GSE43470 | LRP8 | 7804 | 6 | 2 | 35 | |
| GSE46452 | LRP8 | 7804 | 2 | 1 | 56 | |
| GSE47630 | LRP8 | 7804 | 8 | 4 | 28 | |
| GSE54993 | LRP8 | 7804 | 0 | 1 | 69 | |
| GSE54994 | LRP8 | 7804 | 11 | 2 | 40 | |
| GSE60625 | LRP8 | 7804 | 0 | 0 | 11 | |
| GSE74703 | LRP8 | 7804 | 4 | 1 | 31 | |
| GSE74704 | LRP8 | 7804 | 2 | 0 | 18 | |
| TCGA | LRP8 | 7804 | 10 | 19 | 67 |
Total number of gains: 49; Total number of losses: 37; Total Number of normals: 402.
Somatic mutations of LRP8:
Generating mutation plots.
Highly correlated genes for LRP8:
Showing top 20/1639 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRP8 | MTBP | 0.810483 | 3 | 0 | 3 |
| LRP8 | TMEM138 | 0.77475 | 3 | 0 | 3 |
| LRP8 | RNF149 | 0.76445 | 3 | 0 | 3 |
| LRP8 | CABLES2 | 0.759875 | 3 | 0 | 3 |
| LRP8 | SAMD1 | 0.755736 | 3 | 0 | 3 |
| LRP8 | FIGNL1 | 0.753448 | 4 | 0 | 4 |
| LRP8 | LIN9 | 0.749446 | 4 | 0 | 3 |
| LRP8 | ZBTB8OS | 0.745887 | 3 | 0 | 3 |
| LRP8 | NUF2 | 0.74462 | 5 | 0 | 5 |
| LRP8 | SYT7 | 0.743726 | 3 | 0 | 3 |
| LRP8 | BUB1 | 0.742249 | 7 | 0 | 7 |
| LRP8 | RTKN | 0.738814 | 4 | 0 | 4 |
| LRP8 | UHMK1 | 0.733423 | 3 | 0 | 3 |
| LRP8 | TRIM59 | 0.731537 | 3 | 0 | 3 |
| LRP8 | TAF4B | 0.729913 | 3 | 0 | 3 |
| LRP8 | UMPS | 0.729406 | 7 | 0 | 7 |
| LRP8 | CDCA2 | 0.727822 | 5 | 0 | 4 |
| LRP8 | FANCA | 0.722942 | 6 | 0 | 6 |
| LRP8 | TOP1MT | 0.721998 | 5 | 0 | 4 |
| LRP8 | DNAJB11 | 0.719474 | 4 | 0 | 3 |
For details and further investigation, click here
