| Full name: CD40 molecule | Alias Symbol: p50|Bp50 | ||
| Type: protein-coding gene | Cytoband: 20q13.12 | ||
| Entrez ID: 958 | HGNC ID: HGNC:11919 | Ensembl Gene: ENSG00000101017 | OMIM ID: 109535 |
| Drug and gene relationship at DGIdb | |||
CD40 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04064 | NF-kappa B signaling pathway | |
| hsa04620 | Toll-like receptor signaling pathway | |
| hsa05166 | HTLV-I infection |
Expression of CD40:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD40 | 958 | 35150_at | 0.2751 | 0.3581 | |
| GSE20347 | CD40 | 958 | 35150_at | 0.1806 | 0.1052 | |
| GSE23400 | CD40 | 958 | 35150_at | -0.0005 | 0.9909 | |
| GSE26886 | CD40 | 958 | 35150_at | 0.1275 | 0.2253 | |
| GSE29001 | CD40 | 958 | 35150_at | -0.0252 | 0.8801 | |
| GSE38129 | CD40 | 958 | 35150_at | 0.0806 | 0.4369 | |
| GSE45670 | CD40 | 958 | 35150_at | 0.0292 | 0.8383 | |
| GSE53622 | CD40 | 958 | 14347 | -0.5301 | 0.0037 | |
| GSE53624 | CD40 | 958 | 14347 | -1.1802 | 0.0000 | |
| GSE63941 | CD40 | 958 | 35150_at | 0.7486 | 0.2392 | |
| GSE77861 | CD40 | 958 | 35150_at | -0.1062 | 0.3255 | |
| GSE97050 | CD40 | 958 | A_23_P57036 | 0.6650 | 0.1403 | |
| SRP007169 | CD40 | 958 | RNAseq | 0.1683 | 0.7966 | |
| SRP008496 | CD40 | 958 | RNAseq | 0.8518 | 0.0861 | |
| SRP064894 | CD40 | 958 | RNAseq | 0.6516 | 0.0146 | |
| SRP133303 | CD40 | 958 | RNAseq | 0.5117 | 0.0350 | |
| SRP159526 | CD40 | 958 | RNAseq | 0.6085 | 0.2664 | |
| SRP193095 | CD40 | 958 | RNAseq | 0.4915 | 0.0036 | |
| SRP219564 | CD40 | 958 | RNAseq | 1.0390 | 0.0249 | |
| TCGA | CD40 | 958 | RNAseq | 0.2387 | 0.1018 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by CD40 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CD40:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD40 | 958 | 14 | 1 | 15 | |
| GSE20123 | CD40 | 958 | 14 | 1 | 15 | |
| GSE43470 | CD40 | 958 | 12 | 1 | 30 | |
| GSE46452 | CD40 | 958 | 29 | 0 | 30 | |
| GSE47630 | CD40 | 958 | 24 | 1 | 15 | |
| GSE54993 | CD40 | 958 | 0 | 17 | 53 | |
| GSE54994 | CD40 | 958 | 25 | 0 | 28 | |
| GSE60625 | CD40 | 958 | 0 | 0 | 11 | |
| GSE74703 | CD40 | 958 | 10 | 1 | 25 | |
| GSE74704 | CD40 | 958 | 10 | 0 | 10 | |
| TCGA | CD40 | 958 | 46 | 3 | 47 |
Total number of gains: 184; Total number of losses: 25; Total Number of normals: 279.
Somatic mutations of CD40:
Generating mutation plots.
Highly correlated genes for CD40:
Showing top 20/364 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD40 | GPR176 | 0.761608 | 3 | 0 | 3 |
| CD40 | CELA3A | 0.712722 | 3 | 0 | 3 |
| CD40 | ELOVL1 | 0.696157 | 3 | 0 | 3 |
| CD40 | ITGA4 | 0.693947 | 3 | 0 | 3 |
| CD40 | LY6E | 0.688836 | 3 | 0 | 3 |
| CD40 | BCAN | 0.673932 | 5 | 0 | 5 |
| CD40 | ENTPD7 | 0.669134 | 3 | 0 | 3 |
| CD40 | CLEC12A | 0.66621 | 3 | 0 | 3 |
| CD40 | LMAN1 | 0.661547 | 3 | 0 | 3 |
| CD40 | SAG | 0.659116 | 3 | 0 | 3 |
| CD40 | CHAT | 0.655496 | 4 | 0 | 3 |
| CD40 | TNFSF8 | 0.653363 | 4 | 0 | 3 |
| CD40 | TFDP3 | 0.652078 | 5 | 0 | 4 |
| CD40 | ZNF449 | 0.651622 | 3 | 0 | 3 |
| CD40 | DDOST | 0.65034 | 3 | 0 | 3 |
| CD40 | EVA1B | 0.64929 | 3 | 0 | 3 |
| CD40 | BMP8A | 0.647567 | 5 | 0 | 3 |
| CD40 | ADAM22 | 0.647533 | 5 | 0 | 4 |
| CD40 | CYP11A1 | 0.646426 | 3 | 0 | 3 |
| CD40 | AGRP | 0.640782 | 4 | 0 | 3 |
For details and further investigation, click here
