| Full name: aldo-keto reductase family 1 member C2 | Alias Symbol: DD|BABP|DD2|HAKRD|MCDR2 | ||
| Type: protein-coding gene | Cytoband: 10p15.1 | ||
| Entrez ID: 1646 | HGNC ID: HGNC:385 | Ensembl Gene: ENSG00000151632 | OMIM ID: 600450 |
| Drug and gene relationship at DGIdb | |||
Expression of AKR1C2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AKR1C2 | 1646 | 209699_x_at | 0.2157 | 0.9239 | |
| GSE20347 | AKR1C2 | 1646 | 209699_x_at | 1.1192 | 0.0484 | |
| GSE23400 | AKR1C2 | 1646 | 209699_x_at | 0.6105 | 0.0528 | |
| GSE26886 | AKR1C2 | 1646 | 209699_x_at | -0.0671 | 0.9380 | |
| GSE29001 | AKR1C2 | 1646 | 209699_x_at | 0.1693 | 0.8549 | |
| GSE38129 | AKR1C2 | 1646 | 209699_x_at | 1.0084 | 0.0411 | |
| GSE45670 | AKR1C2 | 1646 | 209699_x_at | 0.9481 | 0.1228 | |
| GSE63941 | AKR1C2 | 1646 | 209699_x_at | -1.2635 | 0.6451 | |
| GSE77861 | AKR1C2 | 1646 | 211653_x_at | 0.9441 | 0.3716 | |
| SRP007169 | AKR1C2 | 1646 | RNAseq | 3.2022 | 0.0005 | |
| SRP008496 | AKR1C2 | 1646 | RNAseq | 2.5653 | 0.0032 | |
| SRP064894 | AKR1C2 | 1646 | RNAseq | 0.7850 | 0.0879 | |
| SRP133303 | AKR1C2 | 1646 | RNAseq | 0.5310 | 0.2932 | |
| SRP159526 | AKR1C2 | 1646 | RNAseq | 3.2044 | 0.0000 | |
| SRP193095 | AKR1C2 | 1646 | RNAseq | 0.9349 | 0.0268 | |
| SRP219564 | AKR1C2 | 1646 | RNAseq | 3.0330 | 0.0015 | |
| TCGA | AKR1C2 | 1646 | RNAseq | 0.3344 | 0.2540 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by AKR1C2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of AKR1C2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKR1C2 | 1646 | 6 | 7 | 17 | |
| GSE20123 | AKR1C2 | 1646 | 6 | 6 | 18 | |
| GSE43470 | AKR1C2 | 1646 | 4 | 6 | 33 | |
| GSE46452 | AKR1C2 | 1646 | 2 | 14 | 43 | |
| GSE47630 | AKR1C2 | 1646 | 6 | 14 | 20 | |
| GSE54993 | AKR1C2 | 1646 | 11 | 0 | 59 | |
| GSE54994 | AKR1C2 | 1646 | 4 | 10 | 39 | |
| GSE60625 | AKR1C2 | 1646 | 0 | 0 | 11 | |
| GSE74703 | AKR1C2 | 1646 | 2 | 4 | 30 | |
| GSE74704 | AKR1C2 | 1646 | 1 | 5 | 14 | |
| TCGA | AKR1C2 | 1646 | 19 | 27 | 50 |
Total number of gains: 61; Total number of losses: 93; Total Number of normals: 334.
Somatic mutations of AKR1C2:
Generating mutation plots.
Highly correlated genes for AKR1C2:
Showing top 20/100 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKR1C2 | AKR1C1 | 0.993399 | 9 | 0 | 9 |
| AKR1C2 | AKR1C3 | 0.910459 | 10 | 0 | 10 |
| AKR1C2 | CD44 | 0.777722 | 3 | 0 | 3 |
| AKR1C2 | AKR1C4 | 0.74326 | 10 | 0 | 10 |
| AKR1C2 | GPX2 | 0.723357 | 10 | 0 | 9 |
| AKR1C2 | KRTDAP | 0.704116 | 3 | 0 | 3 |
| AKR1C2 | G6PD | 0.692656 | 9 | 0 | 8 |
| AKR1C2 | AKR1B10 | 0.685399 | 10 | 0 | 9 |
| AKR1C2 | NQO1 | 0.680288 | 10 | 0 | 10 |
| AKR1C2 | TKT | 0.663182 | 8 | 0 | 8 |
| AKR1C2 | SLC7A11 | 0.662605 | 10 | 0 | 10 |
| AKR1C2 | SRXN1 | 0.657132 | 6 | 0 | 5 |
| AKR1C2 | NEFL | 0.638591 | 4 | 0 | 4 |
| AKR1C2 | GCLC | 0.638334 | 9 | 0 | 8 |
| AKR1C2 | CYP4F11 | 0.637892 | 10 | 0 | 8 |
| AKR1C2 | ADAM23 | 0.636492 | 8 | 0 | 8 |
| AKR1C2 | DLX5 | 0.635763 | 7 | 0 | 6 |
| AKR1C2 | TSPAN7 | 0.634713 | 10 | 0 | 10 |
| AKR1C2 | PIR | 0.634413 | 9 | 0 | 9 |
| AKR1C2 | TXNRD1 | 0.619064 | 10 | 0 | 8 |
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