| Full name: SMAD family member 5 | Alias Symbol: Dwfc|JV5-1 | ||
| Type: protein-coding gene | Cytoband: 5q31.1 | ||
| Entrez ID: 4090 | HGNC ID: HGNC:6771 | Ensembl Gene: ENSG00000113658 | OMIM ID: 603110 |
| Drug and gene relationship at DGIdb | |||
SMAD5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway | |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells |
Expression of SMAD5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMAD5 | 4090 | 225219_at | -0.2908 | 0.4305 | |
| GSE20347 | SMAD5 | 4090 | 205187_at | -0.0393 | 0.9215 | |
| GSE23400 | SMAD5 | 4090 | 205188_s_at | 0.2376 | 0.0000 | |
| GSE26886 | SMAD5 | 4090 | 225219_at | -0.3724 | 0.2198 | |
| GSE29001 | SMAD5 | 4090 | 205188_s_at | 0.2195 | 0.1208 | |
| GSE38129 | SMAD5 | 4090 | 205187_at | 0.0249 | 0.9338 | |
| GSE45670 | SMAD5 | 4090 | 225219_at | -0.0038 | 0.9893 | |
| GSE53622 | SMAD5 | 4090 | 71727 | 0.0684 | 0.3102 | |
| GSE53624 | SMAD5 | 4090 | 71727 | 0.2625 | 0.0006 | |
| GSE63941 | SMAD5 | 4090 | 225219_at | -0.8389 | 0.0616 | |
| GSE77861 | SMAD5 | 4090 | 225219_at | 0.4363 | 0.1857 | |
| GSE97050 | SMAD5 | 4090 | A_33_P3220445 | -0.3067 | 0.2212 | |
| SRP007169 | SMAD5 | 4090 | RNAseq | -0.1675 | 0.6939 | |
| SRP008496 | SMAD5 | 4090 | RNAseq | -0.0470 | 0.8356 | |
| SRP064894 | SMAD5 | 4090 | RNAseq | -0.0897 | 0.6772 | |
| SRP133303 | SMAD5 | 4090 | RNAseq | 0.3202 | 0.2337 | |
| SRP159526 | SMAD5 | 4090 | RNAseq | -0.0715 | 0.8379 | |
| SRP193095 | SMAD5 | 4090 | RNAseq | -0.2014 | 0.1053 | |
| SRP219564 | SMAD5 | 4090 | RNAseq | 0.1283 | 0.7299 | |
| TCGA | SMAD5 | 4090 | RNAseq | -0.0092 | 0.8428 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SMAD5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMAD5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMAD5 | 4090 | 3 | 11 | 16 | |
| GSE20123 | SMAD5 | 4090 | 4 | 11 | 15 | |
| GSE43470 | SMAD5 | 4090 | 4 | 6 | 33 | |
| GSE46452 | SMAD5 | 4090 | 0 | 27 | 32 | |
| GSE47630 | SMAD5 | 4090 | 0 | 21 | 19 | |
| GSE54993 | SMAD5 | 4090 | 9 | 1 | 60 | |
| GSE54994 | SMAD5 | 4090 | 3 | 13 | 37 | |
| GSE60625 | SMAD5 | 4090 | 0 | 0 | 11 | |
| GSE74703 | SMAD5 | 4090 | 3 | 5 | 28 | |
| GSE74704 | SMAD5 | 4090 | 3 | 5 | 12 | |
| TCGA | SMAD5 | 4090 | 4 | 36 | 56 |
Total number of gains: 33; Total number of losses: 136; Total Number of normals: 319.
Somatic mutations of SMAD5:
Generating mutation plots.
Highly correlated genes for SMAD5:
Showing top 20/271 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMAD5 | DNAJC24 | 0.780275 | 3 | 0 | 3 |
| SMAD5 | BAG2 | 0.778256 | 3 | 0 | 3 |
| SMAD5 | CD44 | 0.763876 | 3 | 0 | 3 |
| SMAD5 | PRICKLE2 | 0.759172 | 3 | 0 | 3 |
| SMAD5 | PIK3C2A | 0.735802 | 4 | 0 | 4 |
| SMAD5 | CFL2 | 0.734983 | 3 | 0 | 3 |
| SMAD5 | WBP4 | 0.72263 | 3 | 0 | 3 |
| SMAD5 | PLSCR4 | 0.720321 | 3 | 0 | 3 |
| SMAD5 | KIAA2026 | 0.714541 | 3 | 0 | 3 |
| SMAD5 | ZFP30 | 0.705914 | 4 | 0 | 3 |
| SMAD5 | MIER3 | 0.70493 | 3 | 0 | 3 |
| SMAD5 | FAM120AOS | 0.698132 | 3 | 0 | 3 |
| SMAD5 | SNX30 | 0.693032 | 3 | 0 | 3 |
| SMAD5 | PTAR1 | 0.691163 | 4 | 0 | 3 |
| SMAD5 | FEM1C | 0.688785 | 3 | 0 | 3 |
| SMAD5 | RBM7 | 0.684909 | 4 | 0 | 3 |
| SMAD5 | C9orf72 | 0.681528 | 3 | 0 | 3 |
| SMAD5 | ASAP2 | 0.68076 | 3 | 0 | 3 |
| SMAD5 | C5orf24 | 0.678429 | 6 | 0 | 5 |
| SMAD5 | RHOU | 0.677367 | 3 | 0 | 3 |
For details and further investigation, click here
