| Full name: VRK serine/threonine kinase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p16.1 | ||
| Entrez ID: 7444 | HGNC ID: HGNC:12719 | Ensembl Gene: ENSG00000028116 | OMIM ID: 602169 |
| Drug and gene relationship at DGIdb | |||
Expression of VRK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VRK2 | 7444 | 205126_at | -0.0011 | 0.9985 | |
| GSE20347 | VRK2 | 7444 | 205126_at | 0.0246 | 0.8827 | |
| GSE23400 | VRK2 | 7444 | 205126_at | 0.2257 | 0.0058 | |
| GSE26886 | VRK2 | 7444 | 205126_at | 0.5580 | 0.0147 | |
| GSE29001 | VRK2 | 7444 | 205126_at | 0.0163 | 0.9674 | |
| GSE38129 | VRK2 | 7444 | 205126_at | 0.2260 | 0.1415 | |
| GSE45670 | VRK2 | 7444 | 205126_at | 0.4031 | 0.0087 | |
| GSE53622 | VRK2 | 7444 | 131238 | 0.2706 | 0.0000 | |
| GSE53624 | VRK2 | 7444 | 131238 | 0.2413 | 0.0000 | |
| GSE63941 | VRK2 | 7444 | 205126_at | 0.5667 | 0.0888 | |
| GSE77861 | VRK2 | 7444 | 205126_at | 0.4228 | 0.0650 | |
| GSE97050 | VRK2 | 7444 | A_33_P3417990 | 0.2171 | 0.5138 | |
| SRP007169 | VRK2 | 7444 | RNAseq | -0.0673 | 0.8399 | |
| SRP008496 | VRK2 | 7444 | RNAseq | 0.0718 | 0.7756 | |
| SRP064894 | VRK2 | 7444 | RNAseq | -0.0354 | 0.8806 | |
| SRP133303 | VRK2 | 7444 | RNAseq | 0.4202 | 0.0782 | |
| SRP159526 | VRK2 | 7444 | RNAseq | 0.1245 | 0.5662 | |
| SRP193095 | VRK2 | 7444 | RNAseq | -0.0308 | 0.7974 | |
| SRP219564 | VRK2 | 7444 | RNAseq | -0.0395 | 0.9190 | |
| TCGA | VRK2 | 7444 | RNAseq | 0.1934 | 0.0008 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by VRK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VRK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VRK2 | 7444 | 7 | 1 | 22 | |
| GSE20123 | VRK2 | 7444 | 7 | 1 | 22 | |
| GSE43470 | VRK2 | 7444 | 5 | 0 | 38 | |
| GSE46452 | VRK2 | 7444 | 2 | 3 | 54 | |
| GSE47630 | VRK2 | 7444 | 8 | 0 | 32 | |
| GSE54993 | VRK2 | 7444 | 0 | 6 | 64 | |
| GSE54994 | VRK2 | 7444 | 12 | 0 | 41 | |
| GSE60625 | VRK2 | 7444 | 0 | 3 | 8 | |
| GSE74703 | VRK2 | 7444 | 5 | 0 | 31 | |
| GSE74704 | VRK2 | 7444 | 7 | 1 | 12 | |
| TCGA | VRK2 | 7444 | 35 | 3 | 58 |
Total number of gains: 88; Total number of losses: 18; Total Number of normals: 382.
Somatic mutations of VRK2:
Generating mutation plots.
Highly correlated genes for VRK2:
Showing top 20/492 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VRK2 | PRPF40A | 0.77639 | 6 | 0 | 6 |
| VRK2 | CD44 | 0.763497 | 3 | 0 | 3 |
| VRK2 | TAF10 | 0.72447 | 3 | 0 | 3 |
| VRK2 | TRPM4 | 0.704172 | 3 | 0 | 3 |
| VRK2 | KLHL13 | 0.69957 | 3 | 0 | 3 |
| VRK2 | KIN | 0.698881 | 3 | 0 | 3 |
| VRK2 | TRADD | 0.698157 | 4 | 0 | 4 |
| VRK2 | MRPS14 | 0.698123 | 3 | 0 | 3 |
| VRK2 | PLEKHG1 | 0.697357 | 3 | 0 | 3 |
| VRK2 | RBMX2 | 0.697201 | 4 | 0 | 3 |
| VRK2 | FAM161A | 0.694952 | 3 | 0 | 3 |
| VRK2 | LITAF | 0.686056 | 3 | 0 | 3 |
| VRK2 | FOXJ2 | 0.677017 | 3 | 0 | 3 |
| VRK2 | SRPK1 | 0.674875 | 6 | 0 | 5 |
| VRK2 | ERLEC1 | 0.67475 | 3 | 0 | 3 |
| VRK2 | EIF2S2 | 0.672385 | 4 | 0 | 3 |
| VRK2 | KLHL5 | 0.666229 | 3 | 0 | 3 |
| VRK2 | RPS6KB1 | 0.665447 | 4 | 0 | 3 |
| VRK2 | NCAPG | 0.664918 | 6 | 0 | 6 |
| VRK2 | AEBP2 | 0.660309 | 4 | 0 | 3 |
For details and further investigation, click here
