| Full name: CD8b molecule | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p11.2 | ||
| Entrez ID: 926 | HGNC ID: HGNC:1707 | Ensembl Gene: ENSG00000172116 | OMIM ID: 186730 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
CD8B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa04660 | T cell receptor signaling pathway |
Expression of CD8B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD8B | 926 | 207979_s_at | 0.6058 | 0.1171 | |
| GSE20347 | CD8B | 926 | 207979_s_at | 0.0633 | 0.5048 | |
| GSE23400 | CD8B | 926 | 207979_s_at | -0.0151 | 0.6863 | |
| GSE26886 | CD8B | 926 | 207979_s_at | 0.0263 | 0.9215 | |
| GSE29001 | CD8B | 926 | 207979_s_at | 0.1902 | 0.6461 | |
| GSE38129 | CD8B | 926 | 207979_s_at | -0.0334 | 0.8061 | |
| GSE45670 | CD8B | 926 | 207979_s_at | -0.0338 | 0.8628 | |
| GSE53622 | CD8B | 926 | 13565 | 0.0870 | 0.6731 | |
| GSE53624 | CD8B | 926 | 13565 | -0.4057 | 0.0305 | |
| GSE63941 | CD8B | 926 | 207979_s_at | 0.0309 | 0.8333 | |
| GSE77861 | CD8B | 926 | 207979_s_at | -0.0769 | 0.6701 | |
| GSE97050 | CD8B | 926 | A_33_P3234546 | 0.2118 | 0.4785 | |
| SRP064894 | CD8B | 926 | RNAseq | -1.1238 | 0.0061 | |
| SRP133303 | CD8B | 926 | RNAseq | -1.2303 | 0.0009 | |
| SRP219564 | CD8B | 926 | RNAseq | 0.9637 | 0.1152 | |
| TCGA | CD8B | 926 | RNAseq | -0.0440 | 0.9110 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CD8B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CD8B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD8B | 926 | 9 | 2 | 19 | |
| GSE20123 | CD8B | 926 | 9 | 2 | 19 | |
| GSE43470 | CD8B | 926 | 3 | 2 | 38 | |
| GSE46452 | CD8B | 926 | 2 | 3 | 54 | |
| GSE47630 | CD8B | 926 | 7 | 0 | 33 | |
| GSE54993 | CD8B | 926 | 0 | 6 | 64 | |
| GSE54994 | CD8B | 926 | 10 | 0 | 43 | |
| GSE60625 | CD8B | 926 | 0 | 3 | 8 | |
| GSE74703 | CD8B | 926 | 3 | 1 | 32 | |
| GSE74704 | CD8B | 926 | 7 | 0 | 13 | |
| TCGA | CD8B | 926 | 35 | 4 | 57 |
Total number of gains: 85; Total number of losses: 23; Total Number of normals: 380.
Somatic mutations of CD8B:
Generating mutation plots.
Highly correlated genes for CD8B:
Showing top 20/81 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD8B | PRAME | 0.772488 | 3 | 0 | 3 |
| CD8B | CUL9 | 0.757842 | 3 | 0 | 3 |
| CD8B | SALL3 | 0.712398 | 3 | 0 | 3 |
| CD8B | PAFAH1B3 | 0.702297 | 3 | 0 | 3 |
| CD8B | USP49 | 0.697854 | 3 | 0 | 3 |
| CD8B | CDC20B | 0.673726 | 3 | 0 | 3 |
| CD8B | GHRHR | 0.669776 | 3 | 0 | 3 |
| CD8B | HAPLN3 | 0.669135 | 4 | 0 | 3 |
| CD8B | ACVR2B | 0.65903 | 4 | 0 | 3 |
| CD8B | ZNF569 | 0.653419 | 3 | 0 | 3 |
| CD8B | DLK1 | 0.649963 | 4 | 0 | 3 |
| CD8B | CARD8 | 0.641671 | 4 | 0 | 3 |
| CD8B | TBX3 | 0.636861 | 3 | 0 | 3 |
| CD8B | DNAJC5B | 0.63199 | 3 | 0 | 3 |
| CD8B | ITGA2B | 0.627218 | 4 | 0 | 3 |
| CD8B | CCDC28B | 0.620863 | 5 | 0 | 3 |
| CD8B | BTK | 0.616759 | 4 | 0 | 3 |
| CD8B | GZMH | 0.612279 | 5 | 0 | 3 |
| CD8B | ZNF335 | 0.609872 | 4 | 0 | 3 |
| CD8B | TRPM3 | 0.60104 | 5 | 0 | 4 |
For details and further investigation, click here
