TBX3

 

Full name: T-box transcription factor 3 Alias Symbol: TBX3-ISO|XHL
Type: protein-coding gene Cytoband: 12q24.21
Entrez ID: 6926 HGNC ID: HGNC:11602 Ensembl Gene: ENSG00000135111 OMIM ID: 601621
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 5/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

TBX3 involved pathways:

KEGG pathway Description View
hsa04550Signaling pathways regulating pluripotency of stem cells

 

Expression of TBX3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TBX3 6926 225544_at 0.3492 0.3654
GSE20347 TBX3 6926 219682_s_at 0.7070 0.0020
GSE23400 TBX3 6926 219682_s_at 0.1655 0.0193
GSE26886 TBX3 6926 225544_at 0.9765 0.0001
GSE29001 TBX3 6926 219682_s_at 0.5106 0.0846
GSE38129 TBX3 6926 219682_s_at 0.6549 0.0197
GSE45670 TBX3 6926 225544_at 0.4162 0.0682
GSE53622 TBX3 6926 156810 0.5939 0.0000
GSE53624 TBX3 6926 156810 0.6411 0.0000
GSE63941 TBX3 6926 225544_at -1.0171 0.0880
GSE77861 TBX3 6926 225544_at 0.2953 0.0662
GSE97050 TBX3 6926 A_23_P383819 -0.1793 0.5065
SRP007169 TBX3 6926 RNAseq 3.5803 0.0008
SRP064894 TBX3 6926 RNAseq 1.1132 0.0000
SRP133303 TBX3 6926 RNAseq 0.8020 0.0215
SRP193095 TBX3 6926 RNAseq 0.8009 0.0230
SRP219564 TBX3 6926 RNAseq 0.6689 0.0624
TCGA TBX3 6926 RNAseq 0.1584 0.1464

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by TBX3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TBX3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TBX3 6926 4 3 23
GSE20123 TBX3 6926 4 3 23
GSE43470 TBX3 6926 2 0 41
GSE46452 TBX3 6926 9 1 49
GSE47630 TBX3 6926 9 3 28
GSE54993 TBX3 6926 0 5 65
GSE54994 TBX3 6926 6 5 42
GSE60625 TBX3 6926 0 0 11
GSE74703 TBX3 6926 2 0 34
GSE74704 TBX3 6926 2 2 16
TCGA TBX3 6926 22 11 63

Total number of gains: 60; Total number of losses: 33; Total Number of normals: 395.  

 

Somatic mutations of TBX3:

 

Generating mutation plots.

 

Highly correlated genes for TBX3:

 

Showing top 20/277 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TBX3ASMTL0.762423303
TBX3SETDB20.730173303
TBX3LGR60.698326303
TBX3ZNF5750.679075303
TBX3HOXC90.678969403
TBX3SIGIRR0.668047303
TBX3GPR1800.664846403
TBX3ALKBH50.66337403
TBX3PAG10.663072403
TBX3TMEM90.648204706
TBX3WDR60.645885403
TBX3SNHG190.640837303
TBX3NPW0.638352303
TBX3FBRSL10.637068403
TBX3CD8B0.636861303
TBX3CHST100.632389705
TBX3FREM20.631998403
TBX3SHISA20.631329605
TBX3ZNF770.631296403
TBX3GNLY0.629054303

For details and further investigation, click here