| Full name: cell division cycle 23 | Alias Symbol: APC8|ANAPC8|CUT23 | ||
| Type: protein-coding gene | Cytoband: 5q31.2 | ||
| Entrez ID: 8697 | HGNC ID: HGNC:1724 | Ensembl Gene: ENSG00000094880 | OMIM ID: 603462 |
| Drug and gene relationship at DGIdb | |||
CDC23 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle | |
| hsa04114 | Oocyte meiosis | |
| hsa04914 | Progesterone-mediated oocyte maturation | |
| hsa05166 | HTLV-I infection |
Expression of CDC23:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDC23 | 8697 | 202892_at | -0.0826 | 0.8931 | |
| GSE20347 | CDC23 | 8697 | 202892_at | 0.2793 | 0.1781 | |
| GSE23400 | CDC23 | 8697 | 202892_at | 0.5727 | 0.0000 | |
| GSE26886 | CDC23 | 8697 | 202892_at | 0.2390 | 0.2968 | |
| GSE29001 | CDC23 | 8697 | 202892_at | 0.2957 | 0.4496 | |
| GSE38129 | CDC23 | 8697 | 202892_at | 0.3071 | 0.0195 | |
| GSE45670 | CDC23 | 8697 | 202892_at | 0.1131 | 0.4675 | |
| GSE53622 | CDC23 | 8697 | 38514 | 0.1785 | 0.0026 | |
| GSE53624 | CDC23 | 8697 | 38514 | 0.1759 | 0.0139 | |
| GSE63941 | CDC23 | 8697 | 202892_at | 0.8355 | 0.0350 | |
| GSE77861 | CDC23 | 8697 | 202892_at | -0.1766 | 0.5836 | |
| GSE97050 | CDC23 | 8697 | A_23_P133629 | 0.3084 | 0.1861 | |
| SRP007169 | CDC23 | 8697 | RNAseq | -0.2726 | 0.4061 | |
| SRP008496 | CDC23 | 8697 | RNAseq | -0.3854 | 0.0493 | |
| SRP064894 | CDC23 | 8697 | RNAseq | -0.0393 | 0.8200 | |
| SRP133303 | CDC23 | 8697 | RNAseq | 0.6759 | 0.0115 | |
| SRP159526 | CDC23 | 8697 | RNAseq | 0.0293 | 0.9335 | |
| SRP193095 | CDC23 | 8697 | RNAseq | -0.1117 | 0.2678 | |
| SRP219564 | CDC23 | 8697 | RNAseq | 0.1861 | 0.6502 | |
| TCGA | CDC23 | 8697 | RNAseq | 0.1347 | 0.0088 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CDC23 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDC23:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDC23 | 8697 | 3 | 10 | 17 | |
| GSE20123 | CDC23 | 8697 | 4 | 10 | 16 | |
| GSE43470 | CDC23 | 8697 | 4 | 5 | 34 | |
| GSE46452 | CDC23 | 8697 | 0 | 27 | 32 | |
| GSE47630 | CDC23 | 8697 | 0 | 21 | 19 | |
| GSE54993 | CDC23 | 8697 | 9 | 1 | 60 | |
| GSE54994 | CDC23 | 8697 | 3 | 13 | 37 | |
| GSE60625 | CDC23 | 8697 | 0 | 0 | 11 | |
| GSE74703 | CDC23 | 8697 | 3 | 4 | 29 | |
| GSE74704 | CDC23 | 8697 | 3 | 4 | 13 | |
| TCGA | CDC23 | 8697 | 4 | 36 | 56 |
Total number of gains: 33; Total number of losses: 131; Total Number of normals: 324.
Somatic mutations of CDC23:
Generating mutation plots.
Highly correlated genes for CDC23:
Showing top 20/414 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDC23 | SON | 0.723941 | 3 | 0 | 3 |
| CDC23 | INTS2 | 0.675467 | 3 | 0 | 3 |
| CDC23 | CDKN2AIPNL | 0.660962 | 4 | 0 | 4 |
| CDC23 | ANKMY2 | 0.660899 | 4 | 0 | 3 |
| CDC23 | MYO1D | 0.658586 | 3 | 0 | 3 |
| CDC23 | ZNF184 | 0.653552 | 5 | 0 | 4 |
| CDC23 | EIF2AK3 | 0.652792 | 3 | 0 | 3 |
| CDC23 | COQ2 | 0.645348 | 3 | 0 | 3 |
| CDC23 | IFI16 | 0.641892 | 4 | 0 | 4 |
| CDC23 | UBXN8 | 0.640351 | 4 | 0 | 3 |
| CDC23 | RNF13 | 0.637798 | 3 | 0 | 3 |
| CDC23 | ITGB4 | 0.633992 | 3 | 0 | 3 |
| CDC23 | DDX46 | 0.629299 | 13 | 0 | 11 |
| CDC23 | RACGAP1 | 0.626612 | 7 | 0 | 6 |
| CDC23 | MALT1 | 0.626275 | 3 | 0 | 3 |
| CDC23 | DHRS7 | 0.626045 | 4 | 0 | 3 |
| CDC23 | MKKS | 0.62283 | 5 | 0 | 4 |
| CDC23 | SP3 | 0.620618 | 3 | 0 | 3 |
| CDC23 | DCK | 0.619878 | 4 | 0 | 3 |
| CDC23 | ATP1B3 | 0.619593 | 3 | 0 | 3 |
For details and further investigation, click here
