| Full name: integrator complex subunit 2 | Alias Symbol: INT2 | ||
| Type: protein-coding gene | Cytoband: 17q23.2 | ||
| Entrez ID: 57508 | HGNC ID: HGNC:29241 | Ensembl Gene: ENSG00000108506 | OMIM ID: 611346 |
| Drug and gene relationship at DGIdb | |||
Expression of INTS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | INTS2 | 57508 | 224308_s_at | 0.0195 | 0.9846 | |
| GSE26886 | INTS2 | 57508 | 224308_s_at | 0.2742 | 0.3534 | |
| GSE45670 | INTS2 | 57508 | 224308_s_at | 0.2501 | 0.1286 | |
| GSE53622 | INTS2 | 57508 | 15269 | -0.0957 | 0.2140 | |
| GSE53624 | INTS2 | 57508 | 15269 | 0.1945 | 0.0158 | |
| GSE63941 | INTS2 | 57508 | 224308_s_at | 0.3630 | 0.5006 | |
| GSE77861 | INTS2 | 57508 | 224308_s_at | 0.6695 | 0.0787 | |
| SRP007169 | INTS2 | 57508 | RNAseq | 0.4932 | 0.1615 | |
| SRP008496 | INTS2 | 57508 | RNAseq | 0.6384 | 0.0110 | |
| SRP064894 | INTS2 | 57508 | RNAseq | 0.1890 | 0.5718 | |
| SRP133303 | INTS2 | 57508 | RNAseq | 0.6853 | 0.0001 | |
| SRP159526 | INTS2 | 57508 | RNAseq | 0.2854 | 0.1314 | |
| SRP193095 | INTS2 | 57508 | RNAseq | 0.2070 | 0.0117 | |
| SRP219564 | INTS2 | 57508 | RNAseq | -0.0372 | 0.8650 | |
| TCGA | INTS2 | 57508 | RNAseq | 0.1073 | 0.0557 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by INTS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of INTS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | INTS2 | 57508 | 4 | 1 | 25 | |
| GSE20123 | INTS2 | 57508 | 4 | 1 | 25 | |
| GSE43470 | INTS2 | 57508 | 5 | 0 | 38 | |
| GSE46452 | INTS2 | 57508 | 31 | 0 | 28 | |
| GSE47630 | INTS2 | 57508 | 7 | 1 | 32 | |
| GSE54993 | INTS2 | 57508 | 2 | 5 | 63 | |
| GSE54994 | INTS2 | 57508 | 9 | 5 | 39 | |
| GSE60625 | INTS2 | 57508 | 4 | 0 | 7 | |
| GSE74703 | INTS2 | 57508 | 5 | 0 | 31 | |
| GSE74704 | INTS2 | 57508 | 3 | 1 | 16 | |
| TCGA | INTS2 | 57508 | 31 | 6 | 59 |
Total number of gains: 105; Total number of losses: 20; Total Number of normals: 363.
Somatic mutations of INTS2:
Generating mutation plots.
Highly correlated genes for INTS2:
Showing top 20/148 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| INTS2 | CDC23 | 0.675467 | 3 | 0 | 3 |
| INTS2 | SPRED1 | 0.673944 | 4 | 0 | 4 |
| INTS2 | CDC27 | 0.662788 | 4 | 0 | 3 |
| INTS2 | NOL11 | 0.64913 | 6 | 0 | 5 |
| INTS2 | USP32 | 0.64811 | 4 | 0 | 4 |
| INTS2 | DCAF7 | 0.648007 | 3 | 0 | 3 |
| INTS2 | TTC31 | 0.638417 | 3 | 0 | 3 |
| INTS2 | DHX33 | 0.633042 | 5 | 0 | 5 |
| INTS2 | UTP6 | 0.631903 | 3 | 0 | 3 |
| INTS2 | BRCA1 | 0.623809 | 4 | 0 | 4 |
| INTS2 | NEDD1 | 0.620413 | 4 | 0 | 3 |
| INTS2 | UBR1 | 0.618693 | 5 | 0 | 4 |
| INTS2 | MIS12 | 0.615478 | 4 | 0 | 3 |
| INTS2 | PANX1 | 0.606162 | 3 | 0 | 3 |
| INTS2 | MRPS23 | 0.597222 | 6 | 0 | 5 |
| INTS2 | NDUFAF7 | 0.595893 | 4 | 0 | 4 |
| INTS2 | TCF12 | 0.595747 | 5 | 0 | 4 |
| INTS2 | C12orf66 | 0.592259 | 5 | 0 | 4 |
| INTS2 | MRPL45 | 0.592236 | 5 | 0 | 3 |
| INTS2 | FAM76B | 0.589506 | 4 | 0 | 4 |
For details and further investigation, click here
