ATP1B3

 

Full name: ATPase Na+/K+ transporting subunit beta 3 Alias Symbol: FLJ29027|CD298
Type: protein-coding gene Cytoband: 3q23
Entrez ID: 483 HGNC ID: HGNC:806 Ensembl Gene: ENSG00000069849 OMIM ID: 601867
Drug and gene relationship at DGIdb
Screen Evidence:

 

ATP1B3 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04919Thyroid hormone signaling pathway
hsa04960Aldosterone-regulated sodium reabsorption
hsa04961Endocrine and other factor-regulated calcium reabsorption

 

Expression of ATP1B3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ATP1B3 483 208836_at 0.9691 0.0217
GSE20347 ATP1B3 483 208836_at 1.2878 0.0000
GSE23400 ATP1B3 483 208836_at 1.0876 0.0000
GSE26886 ATP1B3 483 208836_at 0.5175 0.0174
GSE29001 ATP1B3 483 208836_at 0.9477 0.0010
GSE38129 ATP1B3 483 208836_at 1.3235 0.0000
GSE45670 ATP1B3 483 208836_at 0.9828 0.0001
GSE53622 ATP1B3 483 28703 1.1313 0.0000
GSE53624 ATP1B3 483 28703 1.4678 0.0000
GSE63941 ATP1B3 483 208836_at -0.0332 0.9673
GSE77861 ATP1B3 483 208836_at 1.1914 0.0011
GSE97050 ATP1B3 483 A_23_P68007 1.1947 0.0620
SRP007169 ATP1B3 483 RNAseq 1.5021 0.0000
SRP008496 ATP1B3 483 RNAseq 2.2696 0.0000
SRP064894 ATP1B3 483 RNAseq 0.8581 0.0006
SRP133303 ATP1B3 483 RNAseq 1.2161 0.0000
SRP159526 ATP1B3 483 RNAseq 1.7390 0.0002
SRP193095 ATP1B3 483 RNAseq 1.1141 0.0000
SRP219564 ATP1B3 483 RNAseq 1.0519 0.0002
TCGA ATP1B3 483 RNAseq 0.5674 0.0000

Upregulated datasets: 12; Downregulated datasets: 0.  

 

Survival by ATP1B3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ATP1B3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ATP1B3 483 20 0 10
GSE20123 ATP1B3 483 20 0 10
GSE43470 ATP1B3 483 22 0 21
GSE46452 ATP1B3 483 15 4 40
GSE47630 ATP1B3 483 19 3 18
GSE54993 ATP1B3 483 1 8 61
GSE54994 ATP1B3 483 34 1 18
GSE60625 ATP1B3 483 0 6 5
GSE74703 ATP1B3 483 19 0 17
GSE74704 ATP1B3 483 14 0 6
TCGA ATP1B3 483 64 3 29

Total number of gains: 228; Total number of losses: 25; Total Number of normals: 235.  

 

Somatic mutations of ATP1B3:

 

Generating mutation plots.

 

Highly correlated genes for ATP1B3:

 

Showing top 20/1741 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ATP1B3CDCA20.784454404
ATP1B3TOP2A0.76789310010
ATP1B3ECT20.75773710010
ATP1B3LRRC8D0.75729811011
ATP1B3DNAJB110.755582706
ATP1B3TFRC0.75389110010
ATP1B3MCM20.750449909
ATP1B3FEN10.749308707
ATP1B3CEP550.74806510010
ATP1B3KIF140.74764910010
ATP1B3ATAD20.74532410010
ATP1B3FAM91A10.743249606
ATP1B3ITGA60.74252511011
ATP1B3CENPF0.74240310010
ATP1B3FZD60.741408807
ATP1B3AURKA0.73922510010
ATP1B3UBE2C0.73896710010
ATP1B3SLC3A20.73424910010
ATP1B3UBE2T0.733596606
ATP1B3MCM40.73328711010

For details and further investigation, click here