| Full name: DEAD-box helicase 46 | Alias Symbol: KIAA0801|FLJ25329|PRPF5|Prp5 | ||
| Type: protein-coding gene | Cytoband: 5q31.1 | ||
| Entrez ID: 9879 | HGNC ID: HGNC:18681 | Ensembl Gene: ENSG00000145833 | OMIM ID: 617848 |
| Drug and gene relationship at DGIdb | |||
Expression of DDX46:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDX46 | 9879 | 202462_s_at | -0.0932 | 0.8651 | |
| GSE20347 | DDX46 | 9879 | 202462_s_at | 0.1298 | 0.3710 | |
| GSE23400 | DDX46 | 9879 | 202462_s_at | 0.3048 | 0.0000 | |
| GSE26886 | DDX46 | 9879 | 202462_s_at | 0.0256 | 0.9124 | |
| GSE29001 | DDX46 | 9879 | 202462_s_at | 0.2896 | 0.1511 | |
| GSE38129 | DDX46 | 9879 | 202462_s_at | 0.2646 | 0.0101 | |
| GSE45670 | DDX46 | 9879 | 202462_s_at | 0.1468 | 0.2386 | |
| GSE53622 | DDX46 | 9879 | 66294 | 0.0942 | 0.1326 | |
| GSE53624 | DDX46 | 9879 | 66294 | 0.1635 | 0.0258 | |
| GSE63941 | DDX46 | 9879 | 202462_s_at | 0.2331 | 0.4455 | |
| GSE77861 | DDX46 | 9879 | 202462_s_at | 0.1024 | 0.6371 | |
| GSE97050 | DDX46 | 9879 | A_32_P105195 | -0.0157 | 0.9500 | |
| SRP007169 | DDX46 | 9879 | RNAseq | 1.1170 | 0.0077 | |
| SRP008496 | DDX46 | 9879 | RNAseq | 1.2242 | 0.0002 | |
| SRP064894 | DDX46 | 9879 | RNAseq | 0.0158 | 0.9167 | |
| SRP133303 | DDX46 | 9879 | RNAseq | 0.0932 | 0.2416 | |
| SRP159526 | DDX46 | 9879 | RNAseq | 0.0046 | 0.9882 | |
| SRP193095 | DDX46 | 9879 | RNAseq | -0.0825 | 0.3480 | |
| SRP219564 | DDX46 | 9879 | RNAseq | -0.0948 | 0.7629 | |
| TCGA | DDX46 | 9879 | RNAseq | -0.0649 | 0.1312 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by DDX46 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDX46:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDX46 | 9879 | 3 | 11 | 16 | |
| GSE20123 | DDX46 | 9879 | 4 | 11 | 15 | |
| GSE43470 | DDX46 | 9879 | 4 | 6 | 33 | |
| GSE46452 | DDX46 | 9879 | 0 | 27 | 32 | |
| GSE47630 | DDX46 | 9879 | 0 | 21 | 19 | |
| GSE54993 | DDX46 | 9879 | 9 | 1 | 60 | |
| GSE54994 | DDX46 | 9879 | 3 | 13 | 37 | |
| GSE60625 | DDX46 | 9879 | 0 | 0 | 11 | |
| GSE74703 | DDX46 | 9879 | 3 | 4 | 29 | |
| GSE74704 | DDX46 | 9879 | 3 | 5 | 12 | |
| TCGA | DDX46 | 9879 | 3 | 36 | 57 |
Total number of gains: 32; Total number of losses: 135; Total Number of normals: 321.
Somatic mutations of DDX46:
Generating mutation plots.
Highly correlated genes for DDX46:
Showing top 20/514 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDX46 | BDP1 | 0.737537 | 4 | 0 | 3 |
| DDX46 | MRPL30 | 0.73454 | 3 | 0 | 3 |
| DDX46 | RRN3 | 0.702101 | 4 | 0 | 4 |
| DDX46 | CEP44 | 0.70069 | 3 | 0 | 3 |
| DDX46 | RPAIN | 0.694831 | 3 | 0 | 3 |
| DDX46 | PDZD8 | 0.687564 | 3 | 0 | 3 |
| DDX46 | NAA30 | 0.686583 | 3 | 0 | 3 |
| DDX46 | ZNF23 | 0.681823 | 3 | 0 | 3 |
| DDX46 | MTCH2 | 0.675992 | 3 | 0 | 3 |
| DDX46 | DSE | 0.66755 | 4 | 0 | 4 |
| DDX46 | EGLN3 | 0.65757 | 3 | 0 | 3 |
| DDX46 | VRK2 | 0.650194 | 4 | 0 | 3 |
| DDX46 | PLS3 | 0.641567 | 3 | 0 | 3 |
| DDX46 | CREB1 | 0.641011 | 6 | 0 | 6 |
| DDX46 | UBLCP1 | 0.640181 | 5 | 0 | 4 |
| DDX46 | NAPEPLD | 0.638103 | 3 | 0 | 3 |
| DDX46 | TMEM117 | 0.637606 | 3 | 0 | 3 |
| DDX46 | FNIP1 | 0.636377 | 6 | 0 | 5 |
| DDX46 | MRPL37 | 0.6361 | 3 | 0 | 3 |
| DDX46 | PGM3 | 0.63409 | 4 | 0 | 3 |
For details and further investigation, click here
