| Full name: centromere protein K | Alias Symbol: FKSG14|SOLT|CENP-K | ||
| Type: protein-coding gene | Cytoband: 5q12.3 | ||
| Entrez ID: 64105 | HGNC ID: HGNC:29479 | Ensembl Gene: ENSG00000123219 | OMIM ID: 611502 |
| Drug and gene relationship at DGIdb | |||
Expression of CENPK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CENPK | 64105 | 222848_at | 1.0939 | 0.0167 | |
| GSE26886 | CENPK | 64105 | 222848_at | 0.4130 | 0.2999 | |
| GSE45670 | CENPK | 64105 | 222848_at | 0.9895 | 0.0000 | |
| GSE53622 | CENPK | 64105 | 127425 | 0.8435 | 0.0000 | |
| GSE53624 | CENPK | 64105 | 127425 | 1.0459 | 0.0000 | |
| GSE63941 | CENPK | 64105 | 222848_at | 3.0305 | 0.0000 | |
| GSE77861 | CENPK | 64105 | 222848_at | 0.7117 | 0.1549 | |
| GSE97050 | CENPK | 64105 | A_23_P155989 | 0.2896 | 0.3189 | |
| SRP007169 | CENPK | 64105 | RNAseq | 1.7673 | 0.0007 | |
| SRP008496 | CENPK | 64105 | RNAseq | 1.1819 | 0.0061 | |
| SRP064894 | CENPK | 64105 | RNAseq | 0.7021 | 0.0388 | |
| SRP133303 | CENPK | 64105 | RNAseq | 1.0261 | 0.0000 | |
| SRP159526 | CENPK | 64105 | RNAseq | 0.7147 | 0.1211 | |
| SRP193095 | CENPK | 64105 | RNAseq | 0.3787 | 0.0064 | |
| SRP219564 | CENPK | 64105 | RNAseq | 0.8497 | 0.2764 | |
| TCGA | CENPK | 64105 | RNAseq | 1.1268 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by CENPK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CENPK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CENPK | 64105 | 0 | 13 | 17 | |
| GSE20123 | CENPK | 64105 | 0 | 13 | 17 | |
| GSE43470 | CENPK | 64105 | 1 | 13 | 29 | |
| GSE46452 | CENPK | 64105 | 0 | 28 | 31 | |
| GSE47630 | CENPK | 64105 | 2 | 17 | 21 | |
| GSE54993 | CENPK | 64105 | 8 | 1 | 61 | |
| GSE54994 | CENPK | 64105 | 1 | 19 | 33 | |
| GSE60625 | CENPK | 64105 | 0 | 0 | 11 | |
| GSE74703 | CENPK | 64105 | 1 | 9 | 26 | |
| GSE74704 | CENPK | 64105 | 0 | 6 | 14 | |
| TCGA | CENPK | 64105 | 4 | 50 | 42 |
Total number of gains: 17; Total number of losses: 169; Total Number of normals: 302.
Somatic mutations of CENPK:
Generating mutation plots.
Highly correlated genes for CENPK:
Showing top 20/899 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CENPK | DEPDC1B | 0.82679 | 8 | 0 | 8 |
| CENPK | CDK1 | 0.779319 | 8 | 0 | 8 |
| CENPK | TTK | 0.764945 | 8 | 0 | 8 |
| CENPK | SLC36A4 | 0.739408 | 3 | 0 | 3 |
| CENPK | DEPDC1 | 0.739365 | 8 | 0 | 8 |
| CENPK | NCAPG | 0.736593 | 5 | 0 | 4 |
| CENPK | ECT2 | 0.733167 | 8 | 0 | 8 |
| CENPK | CDCA5 | 0.731447 | 7 | 0 | 7 |
| CENPK | AURKB | 0.73066 | 8 | 0 | 8 |
| CENPK | FOXM1 | 0.729876 | 8 | 0 | 8 |
| CENPK | NCAPH | 0.729522 | 5 | 0 | 5 |
| CENPK | UBE2S | 0.726309 | 3 | 0 | 3 |
| CENPK | RAD51AP1 | 0.726008 | 9 | 0 | 9 |
| CENPK | KIF4A | 0.724568 | 8 | 0 | 8 |
| CENPK | CDC25C | 0.722224 | 7 | 0 | 7 |
| CENPK | KIF15 | 0.721955 | 8 | 0 | 8 |
| CENPK | BRIP1 | 0.721633 | 8 | 0 | 8 |
| CENPK | KIF18B | 0.719717 | 7 | 0 | 7 |
| CENPK | PTTG1 | 0.718221 | 7 | 0 | 7 |
| CENPK | MKI67 | 0.718085 | 8 | 0 | 8 |
For details and further investigation, click here
