| Full name: centromere protein A | Alias Symbol: CENP-A|CenH3 | ||
| Type: protein-coding gene | Cytoband: 2p23.3 | ||
| Entrez ID: 1058 | HGNC ID: HGNC:1851 | Ensembl Gene: ENSG00000115163 | OMIM ID: 117139 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CENPA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CENPA | 1058 | 210821_x_at | 1.1480 | 0.0300 | |
| GSE20347 | CENPA | 1058 | 210821_x_at | 0.5215 | 0.0000 | |
| GSE23400 | CENPA | 1058 | 210821_x_at | 0.3190 | 0.0000 | |
| GSE26886 | CENPA | 1058 | 210821_x_at | 0.4541 | 0.0068 | |
| GSE29001 | CENPA | 1058 | 210821_x_at | 0.2338 | 0.1590 | |
| GSE38129 | CENPA | 1058 | 210821_x_at | 0.7263 | 0.0000 | |
| GSE45670 | CENPA | 1058 | 210821_x_at | 1.0766 | 0.0002 | |
| GSE53622 | CENPA | 1058 | 23614 | 1.7463 | 0.0000 | |
| GSE53624 | CENPA | 1058 | 23614 | 1.8825 | 0.0000 | |
| GSE63941 | CENPA | 1058 | 210821_x_at | 2.4139 | 0.0003 | |
| GSE77861 | CENPA | 1058 | 210821_x_at | 0.3193 | 0.1150 | |
| GSE97050 | CENPA | 1058 | A_24_P413884 | 0.7392 | 0.1406 | |
| SRP007169 | CENPA | 1058 | RNAseq | 1.8813 | 0.0007 | |
| SRP008496 | CENPA | 1058 | RNAseq | 1.9019 | 0.0000 | |
| SRP064894 | CENPA | 1058 | RNAseq | 2.1614 | 0.0000 | |
| SRP133303 | CENPA | 1058 | RNAseq | 2.0166 | 0.0000 | |
| SRP159526 | CENPA | 1058 | RNAseq | 2.0251 | 0.0002 | |
| SRP193095 | CENPA | 1058 | RNAseq | 1.4105 | 0.0000 | |
| SRP219564 | CENPA | 1058 | RNAseq | 1.4368 | 0.1654 | |
| TCGA | CENPA | 1058 | RNAseq | 1.7176 | 0.0000 |
Upregulated datasets: 12; Downregulated datasets: 0.
Survival by CENPA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CENPA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CENPA | 1058 | 11 | 2 | 17 | |
| GSE20123 | CENPA | 1058 | 11 | 2 | 17 | |
| GSE43470 | CENPA | 1058 | 3 | 1 | 39 | |
| GSE46452 | CENPA | 1058 | 3 | 4 | 52 | |
| GSE47630 | CENPA | 1058 | 8 | 0 | 32 | |
| GSE54993 | CENPA | 1058 | 0 | 6 | 64 | |
| GSE54994 | CENPA | 1058 | 10 | 0 | 43 | |
| GSE60625 | CENPA | 1058 | 0 | 3 | 8 | |
| GSE74703 | CENPA | 1058 | 3 | 0 | 33 | |
| GSE74704 | CENPA | 1058 | 9 | 1 | 10 | |
| TCGA | CENPA | 1058 | 37 | 2 | 57 |
Total number of gains: 95; Total number of losses: 21; Total Number of normals: 372.
Somatic mutations of CENPA:
Generating mutation plots.
Highly correlated genes for CENPA:
Showing top 20/1867 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CENPA | KNSTRN | 0.803273 | 7 | 0 | 7 |
| CENPA | MMS22L | 0.792301 | 3 | 0 | 3 |
| CENPA | CAD | 0.790608 | 11 | 0 | 10 |
| CENPA | DEPDC1B | 0.788976 | 7 | 0 | 7 |
| CENPA | UBE2C | 0.787606 | 13 | 0 | 13 |
| CENPA | DNAJB11 | 0.787535 | 5 | 0 | 5 |
| CENPA | UBE2T | 0.782253 | 9 | 0 | 9 |
| CENPA | TPX2 | 0.778085 | 12 | 0 | 12 |
| CENPA | NUF2 | 0.775573 | 9 | 0 | 8 |
| CENPA | NCAPH | 0.774616 | 9 | 0 | 9 |
| CENPA | SKA3 | 0.773623 | 7 | 0 | 7 |
| CENPA | TTK | 0.771301 | 11 | 0 | 11 |
| CENPA | GINS1 | 0.765907 | 11 | 0 | 11 |
| CENPA | CDCA3 | 0.763157 | 13 | 0 | 12 |
| CENPA | BIRC5 | 0.762907 | 12 | 0 | 11 |
| CENPA | MTFR2 | 0.762283 | 7 | 0 | 7 |
| CENPA | CDCA2 | 0.761438 | 7 | 0 | 6 |
| CENPA | MYBL2 | 0.761347 | 12 | 0 | 12 |
| CENPA | RAD18 | 0.760652 | 3 | 0 | 3 |
| CENPA | CDT1 | 0.759656 | 12 | 0 | 11 |
For details and further investigation, click here
