| Full name: TOPBP1 interacting checkpoint and replication regulator | Alias Symbol: MGC45866|FLJ41618|Treslin|SLD3 | ||
| Type: protein-coding gene | Cytoband: 15q26.1 | ||
| Entrez ID: 90381 | HGNC ID: HGNC:28704 | Ensembl Gene: ENSG00000140534 | OMIM ID: 613298 |
| Drug and gene relationship at DGIdb | |||
Expression of TICRR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TICRR | 90381 | 230021_at | 0.8555 | 0.0721 | |
| GSE26886 | TICRR | 90381 | 230021_at | 0.2710 | 0.1852 | |
| GSE45670 | TICRR | 90381 | 230021_at | 0.5981 | 0.0012 | |
| GSE53622 | TICRR | 90381 | 44105 | 1.0346 | 0.0000 | |
| GSE53624 | TICRR | 90381 | 44105 | 1.1667 | 0.0000 | |
| GSE63941 | TICRR | 90381 | 230021_at | 1.8409 | 0.0021 | |
| GSE77861 | TICRR | 90381 | 232475_at | -0.1098 | 0.4253 | |
| SRP007169 | TICRR | 90381 | RNAseq | 2.1199 | 0.0000 | |
| SRP008496 | TICRR | 90381 | RNAseq | 1.2612 | 0.0026 | |
| SRP064894 | TICRR | 90381 | RNAseq | 0.3341 | 0.2313 | |
| SRP133303 | TICRR | 90381 | RNAseq | 0.5474 | 0.2402 | |
| SRP159526 | TICRR | 90381 | RNAseq | 1.2373 | 0.0017 | |
| SRP193095 | TICRR | 90381 | RNAseq | 0.8781 | 0.0001 | |
| SRP219564 | TICRR | 90381 | RNAseq | 0.7237 | 0.2871 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by TICRR expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of TICRR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TICRR | 90381 | 8 | 2 | 20 | |
| GSE20123 | TICRR | 90381 | 8 | 2 | 20 | |
| GSE43470 | TICRR | 90381 | 5 | 4 | 34 | |
| GSE46452 | TICRR | 90381 | 3 | 7 | 49 | |
| GSE47630 | TICRR | 90381 | 8 | 11 | 21 | |
| GSE54993 | TICRR | 90381 | 4 | 6 | 60 | |
| GSE54994 | TICRR | 90381 | 7 | 6 | 40 | |
| GSE60625 | TICRR | 90381 | 4 | 0 | 7 | |
| GSE74703 | TICRR | 90381 | 4 | 3 | 29 | |
| GSE74704 | TICRR | 90381 | 4 | 2 | 14 | |
| TCGA | TICRR | 90381 | 17 | 12 | 67 |
Total number of gains: 72; Total number of losses: 55; Total Number of normals: 361.
Somatic mutations of TICRR:
Generating mutation plots.
Highly correlated genes for TICRR:
Showing top 20/392 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TICRR | BLM | 0.817634 | 5 | 0 | 5 |
| TICRR | PARPBP | 0.786487 | 4 | 0 | 4 |
| TICRR | PRC1 | 0.762484 | 6 | 0 | 6 |
| TICRR | CDCA5 | 0.747523 | 6 | 0 | 6 |
| TICRR | FANCI | 0.745536 | 6 | 0 | 5 |
| TICRR | TRIP13 | 0.744533 | 6 | 0 | 6 |
| TICRR | KIF2C | 0.734221 | 6 | 0 | 6 |
| TICRR | ZWILCH | 0.729566 | 5 | 0 | 5 |
| TICRR | CDC25C | 0.729428 | 6 | 0 | 6 |
| TICRR | CDCA8 | 0.722748 | 6 | 0 | 6 |
| TICRR | NUSAP1 | 0.72272 | 6 | 0 | 6 |
| TICRR | RAD51 | 0.719531 | 6 | 0 | 6 |
| TICRR | BUB1B | 0.717019 | 4 | 0 | 4 |
| TICRR | NUDT1 | 0.716558 | 5 | 0 | 4 |
| TICRR | MCM2 | 0.713299 | 6 | 0 | 6 |
| TICRR | SPAG5 | 0.710898 | 6 | 0 | 6 |
| TICRR | LSM4 | 0.710199 | 3 | 0 | 3 |
| TICRR | CENPE | 0.709501 | 5 | 0 | 5 |
| TICRR | CDCA2 | 0.70801 | 4 | 0 | 4 |
| TICRR | UBE2C | 0.707341 | 6 | 0 | 6 |
For details and further investigation, click here
