| Full name: cyclin dependent kinase 14 | Alias Symbol: PFTAIRE1 | ||
| Type: protein-coding gene | Cytoband: 7q21.13 | ||
| Entrez ID: 5218 | HGNC ID: HGNC:8883 | Ensembl Gene: ENSG00000058091 | OMIM ID: 610679 |
| Drug and gene relationship at DGIdb | |||
Expression of CDK14:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDK14 | 5218 | 204604_at | 1.2340 | 0.1110 | |
| GSE20347 | CDK14 | 5218 | 204604_at | 1.6057 | 0.0000 | |
| GSE23400 | CDK14 | 5218 | 204604_at | 0.6723 | 0.0000 | |
| GSE26886 | CDK14 | 5218 | 243459_x_at | 0.2386 | 0.0823 | |
| GSE29001 | CDK14 | 5218 | 204604_at | 1.2217 | 0.0003 | |
| GSE38129 | CDK14 | 5218 | 204604_at | 1.2348 | 0.0008 | |
| GSE45670 | CDK14 | 5218 | 204604_at | 0.2513 | 0.6880 | |
| GSE53622 | CDK14 | 5218 | 23532 | 1.6721 | 0.0000 | |
| GSE53624 | CDK14 | 5218 | 23532 | 1.7669 | 0.0000 | |
| GSE63941 | CDK14 | 5218 | 204604_at | -1.7022 | 0.0195 | |
| GSE77861 | CDK14 | 5218 | 243459_x_at | -0.0797 | 0.6227 | |
| GSE97050 | CDK14 | 5218 | A_24_P29733 | 0.5977 | 0.2155 | |
| SRP007169 | CDK14 | 5218 | RNAseq | 2.9826 | 0.0000 | |
| SRP008496 | CDK14 | 5218 | RNAseq | 4.4402 | 0.0000 | |
| SRP064894 | CDK14 | 5218 | RNAseq | 1.8089 | 0.0000 | |
| SRP133303 | CDK14 | 5218 | RNAseq | 1.8463 | 0.0000 | |
| SRP159526 | CDK14 | 5218 | RNAseq | 1.6697 | 0.0000 | |
| SRP193095 | CDK14 | 5218 | RNAseq | 1.7399 | 0.0000 | |
| SRP219564 | CDK14 | 5218 | RNAseq | 1.6594 | 0.0115 | |
| TCGA | CDK14 | 5218 | RNAseq | -0.0395 | 0.7343 |
Upregulated datasets: 12; Downregulated datasets: 1.
Survival by CDK14 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDK14:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDK14 | 5218 | 13 | 1 | 16 | |
| GSE20123 | CDK14 | 5218 | 13 | 0 | 17 | |
| GSE43470 | CDK14 | 5218 | 6 | 1 | 36 | |
| GSE46452 | CDK14 | 5218 | 11 | 0 | 48 | |
| GSE47630 | CDK14 | 5218 | 9 | 2 | 29 | |
| GSE54993 | CDK14 | 5218 | 1 | 8 | 61 | |
| GSE54994 | CDK14 | 5218 | 17 | 2 | 34 | |
| GSE60625 | CDK14 | 5218 | 0 | 0 | 11 | |
| GSE74703 | CDK14 | 5218 | 5 | 1 | 30 | |
| GSE74704 | CDK14 | 5218 | 9 | 0 | 11 | |
| TCGA | CDK14 | 5218 | 56 | 4 | 36 |
Total number of gains: 140; Total number of losses: 19; Total Number of normals: 329.
Somatic mutations of CDK14:
Generating mutation plots.
Highly correlated genes for CDK14:
Showing top 20/1049 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDK14 | WDR86 | 0.781039 | 3 | 0 | 3 |
| CDK14 | FADS1 | 0.762711 | 3 | 0 | 3 |
| CDK14 | FCGR3A | 0.760601 | 3 | 0 | 3 |
| CDK14 | RAB34 | 0.749504 | 3 | 0 | 3 |
| CDK14 | TRAM2 | 0.74663 | 10 | 0 | 9 |
| CDK14 | GNG10 | 0.741862 | 3 | 0 | 3 |
| CDK14 | KCTD10 | 0.7412 | 3 | 0 | 3 |
| CDK14 | LBH | 0.738808 | 10 | 0 | 10 |
| CDK14 | CDH11 | 0.737602 | 10 | 0 | 9 |
| CDK14 | LRRC8C | 0.736814 | 3 | 0 | 3 |
| CDK14 | MAPRE3 | 0.732689 | 3 | 0 | 3 |
| CDK14 | SPON2 | 0.728795 | 3 | 0 | 3 |
| CDK14 | ZNF787 | 0.721807 | 3 | 0 | 3 |
| CDK14 | SMYD3 | 0.716267 | 8 | 0 | 7 |
| CDK14 | IL2RA | 0.71389 | 3 | 0 | 3 |
| CDK14 | LGALS1 | 0.710842 | 10 | 0 | 10 |
| CDK14 | FUT8 | 0.708885 | 9 | 0 | 9 |
| CDK14 | EMILIN2 | 0.704834 | 5 | 0 | 4 |
| CDK14 | CERS2 | 0.701688 | 7 | 0 | 6 |
| CDK14 | ZDHHC14 | 0.699125 | 3 | 0 | 3 |
For details and further investigation, click here
