| Full name: SET and MYND domain containing 3 | Alias Symbol: KMT3E | ||
| Type: protein-coding gene | Cytoband: 1q44 | ||
| Entrez ID: 64754 | HGNC ID: HGNC:15513 | Ensembl Gene: ENSG00000185420 | OMIM ID: 608783 |
| Drug and gene relationship at DGIdb | |||
Expression of SMYD3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMYD3 | 64754 | 218788_s_at | 0.7354 | 0.1641 | |
| GSE20347 | SMYD3 | 64754 | 218788_s_at | 1.7069 | 0.0000 | |
| GSE23400 | SMYD3 | 64754 | 218788_s_at | 0.7692 | 0.0000 | |
| GSE26886 | SMYD3 | 64754 | 218788_s_at | 1.8449 | 0.0000 | |
| GSE29001 | SMYD3 | 64754 | 218788_s_at | 0.8617 | 0.0009 | |
| GSE38129 | SMYD3 | 64754 | 218788_s_at | 1.5211 | 0.0000 | |
| GSE45670 | SMYD3 | 64754 | 218788_s_at | 0.2800 | 0.4573 | |
| GSE53622 | SMYD3 | 64754 | 22251 | 0.7185 | 0.0000 | |
| GSE53624 | SMYD3 | 64754 | 28818 | 1.6953 | 0.0000 | |
| GSE63941 | SMYD3 | 64754 | 218788_s_at | -0.2240 | 0.7553 | |
| GSE77861 | SMYD3 | 64754 | 218788_s_at | 1.2639 | 0.0048 | |
| GSE97050 | SMYD3 | 64754 | A_23_P51410 | -0.2844 | 0.5555 | |
| SRP007169 | SMYD3 | 64754 | RNAseq | 1.2873 | 0.0361 | |
| SRP008496 | SMYD3 | 64754 | RNAseq | 1.6905 | 0.0000 | |
| SRP064894 | SMYD3 | 64754 | RNAseq | 0.8657 | 0.0003 | |
| SRP133303 | SMYD3 | 64754 | RNAseq | 0.8770 | 0.0000 | |
| SRP159526 | SMYD3 | 64754 | RNAseq | 1.1917 | 0.0000 | |
| SRP193095 | SMYD3 | 64754 | RNAseq | 1.1839 | 0.0000 | |
| SRP219564 | SMYD3 | 64754 | RNAseq | 0.2878 | 0.6260 | |
| TCGA | SMYD3 | 64754 | RNAseq | 0.2026 | 0.0418 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by SMYD3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMYD3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMYD3 | 64754 | 7 | 1 | 22 | |
| GSE20123 | SMYD3 | 64754 | 7 | 1 | 22 | |
| GSE43470 | SMYD3 | 64754 | 6 | 3 | 34 | |
| GSE46452 | SMYD3 | 64754 | 4 | 2 | 53 | |
| GSE47630 | SMYD3 | 64754 | 15 | 1 | 24 | |
| GSE54993 | SMYD3 | 64754 | 0 | 6 | 64 | |
| GSE54994 | SMYD3 | 64754 | 18 | 0 | 35 | |
| GSE60625 | SMYD3 | 64754 | 0 | 0 | 11 | |
| GSE74703 | SMYD3 | 64754 | 6 | 1 | 29 | |
| GSE74704 | SMYD3 | 64754 | 2 | 0 | 18 | |
| TCGA | SMYD3 | 64754 | 46 | 6 | 44 |
Total number of gains: 111; Total number of losses: 21; Total Number of normals: 356.
Somatic mutations of SMYD3:
Generating mutation plots.
Highly correlated genes for SMYD3:
Showing top 20/1816 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMYD3 | NAF1 | 0.76058 | 3 | 0 | 3 |
| SMYD3 | SUZ12 | 0.752745 | 5 | 0 | 5 |
| SMYD3 | GHDC | 0.746048 | 3 | 0 | 3 |
| SMYD3 | DDHD1 | 0.738948 | 6 | 0 | 6 |
| SMYD3 | ALKBH6 | 0.738373 | 3 | 0 | 3 |
| SMYD3 | ORAI1 | 0.736957 | 3 | 0 | 3 |
| SMYD3 | GNG10 | 0.730131 | 3 | 0 | 3 |
| SMYD3 | RAB34 | 0.729266 | 3 | 0 | 3 |
| SMYD3 | CEP170 | 0.728447 | 3 | 0 | 3 |
| SMYD3 | CRTC2 | 0.723953 | 3 | 0 | 3 |
| SMYD3 | DESI2 | 0.722651 | 10 | 0 | 10 |
| SMYD3 | CDK14 | 0.716267 | 8 | 0 | 7 |
| SMYD3 | ZNF532 | 0.716225 | 9 | 0 | 9 |
| SMYD3 | ACACA | 0.714977 | 4 | 0 | 3 |
| SMYD3 | MIEN1 | 0.714465 | 3 | 0 | 3 |
| SMYD3 | DDX20 | 0.71348 | 4 | 0 | 4 |
| SMYD3 | NACC1 | 0.712121 | 3 | 0 | 3 |
| SMYD3 | ATXN1L | 0.711887 | 3 | 0 | 3 |
| SMYD3 | MAD2L2 | 0.711717 | 5 | 0 | 5 |
| SMYD3 | B4GALNT4 | 0.710501 | 3 | 0 | 3 |
For details and further investigation, click here
