CDK6

 

Full name: cyclin dependent kinase 6 Alias Symbol: PLSTIRE
Type: protein-coding gene Cytoband: 7q21.2
Entrez ID: 1021 HGNC ID: HGNC:1777 Ensembl Gene: ENSG00000105810 OMIM ID: 603368
Drug and gene relationship at DGIdb
Screen Evidence:

 

CDK6 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa05161Hepatitis B
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
hsa05214Glioma
hsa05218Melanoma
hsa05220Chronic myeloid leukemia
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer

 

Expression of CDK6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDK6 1021 224847_at 1.1335 0.0558
GSE20347 CDK6 1021 207143_at 0.3459 0.0024
GSE23400 CDK6 1021 207143_at 0.0824 0.0637
GSE26886 CDK6 1021 224851_at 1.2010 0.0115
GSE29001 CDK6 1021 207143_at 0.1143 0.4132
GSE38129 CDK6 1021 207143_at 0.4270 0.0001
GSE45670 CDK6 1021 224847_at 1.4065 0.0008
GSE53622 CDK6 1021 42735 1.1819 0.0000
GSE53624 CDK6 1021 42735 1.4882 0.0000
GSE63941 CDK6 1021 224851_at 1.1147 0.0967
GSE77861 CDK6 1021 224847_at 0.9931 0.0159
GSE97050 CDK6 1021 A_24_P166663 0.9096 0.0700
SRP007169 CDK6 1021 RNAseq 2.3098 0.0000
SRP008496 CDK6 1021 RNAseq 2.3930 0.0000
SRP064894 CDK6 1021 RNAseq 1.3185 0.0000
SRP133303 CDK6 1021 RNAseq 1.8020 0.0000
SRP159526 CDK6 1021 RNAseq 1.3378 0.0008
SRP193095 CDK6 1021 RNAseq 1.4008 0.0000
SRP219564 CDK6 1021 RNAseq 1.2250 0.0069
TCGA CDK6 1021 RNAseq 0.0947 0.3019

Upregulated datasets: 11; Downregulated datasets: 0.  

 

Survival by CDK6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CDK6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDK6 1021 13 0 17
GSE20123 CDK6 1021 13 0 17
GSE43470 CDK6 1021 7 1 35
GSE46452 CDK6 1021 11 0 48
GSE47630 CDK6 1021 9 2 29
GSE54993 CDK6 1021 1 9 60
GSE54994 CDK6 1021 16 2 35
GSE60625 CDK6 1021 0 0 11
GSE74703 CDK6 1021 6 1 29
GSE74704 CDK6 1021 9 0 11
TCGA CDK6 1021 56 4 36

Total number of gains: 141; Total number of losses: 19; Total Number of normals: 328.  

 

Somatic mutations of CDK6:

 

Generating mutation plots.

 

Highly correlated genes for CDK6:

 

Showing top 20/1642 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDK6ALG10.780289303
CDK6SLC16A20.756842303
CDK6FADS10.745511303
CDK6MSN0.745355707
CDK6FBLIM10.739153706
CDK6FAM126A0.733109303
CDK6ARPC1B0.729152808
CDK6TTL0.728566706
CDK6YWHAG0.727923505
CDK6XPR10.725102706
CDK6BTF3L40.724735303
CDK6NXN0.723711303
CDK6XPO70.720081404
CDK6KCNS30.710753505
CDK6AFAP1L20.707408303
CDK6SLC39A10.707082605
CDK6RAB340.706331303
CDK6TMEM184B0.702961807
CDK6CDK2AP10.702773403
CDK6ANLN0.702341807

For details and further investigation, click here