| Full name: cadherin EGF LAG seven-pass G-type receptor 3 | Alias Symbol: MEGF2|HFMI1|FMI1|CDHF11|ADGRC3 | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 1951 | HGNC ID: HGNC:3230 | Ensembl Gene: ENSG00000008300 | OMIM ID: 604264 |
| Drug and gene relationship at DGIdb | |||
Expression of CELSR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CELSR3 | 1951 | 40020_at | 1.2885 | 0.1328 | |
| GSE20347 | CELSR3 | 1951 | 40020_at | 0.4475 | 0.0012 | |
| GSE23400 | CELSR3 | 1951 | 40020_at | 0.2283 | 0.0000 | |
| GSE26886 | CELSR3 | 1951 | 40020_at | 0.8272 | 0.0082 | |
| GSE29001 | CELSR3 | 1951 | 40020_at | 0.7781 | 0.0292 | |
| GSE38129 | CELSR3 | 1951 | 40020_at | 0.3861 | 0.0037 | |
| GSE45670 | CELSR3 | 1951 | 40020_at | 0.8203 | 0.0057 | |
| GSE53622 | CELSR3 | 1951 | 78712 | 0.4953 | 0.0000 | |
| GSE53624 | CELSR3 | 1951 | 24587 | 1.5312 | 0.0000 | |
| GSE63941 | CELSR3 | 1951 | 40020_at | 0.4801 | 0.4729 | |
| GSE77861 | CELSR3 | 1951 | 40020_at | 0.1405 | 0.3323 | |
| GSE97050 | CELSR3 | 1951 | A_23_P92093 | 0.6213 | 0.2149 | |
| SRP007169 | CELSR3 | 1951 | RNAseq | 2.3755 | 0.0003 | |
| SRP008496 | CELSR3 | 1951 | RNAseq | 3.2037 | 0.0001 | |
| SRP064894 | CELSR3 | 1951 | RNAseq | 2.9328 | 0.0000 | |
| SRP133303 | CELSR3 | 1951 | RNAseq | 2.2288 | 0.0000 | |
| SRP159526 | CELSR3 | 1951 | RNAseq | 1.3909 | 0.0005 | |
| SRP193095 | CELSR3 | 1951 | RNAseq | 0.9161 | 0.0011 | |
| SRP219564 | CELSR3 | 1951 | RNAseq | 2.8593 | 0.0035 | |
| TCGA | CELSR3 | 1951 | RNAseq | 0.3207 | 0.0599 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by CELSR3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CELSR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CELSR3 | 1951 | 0 | 18 | 12 | |
| GSE20123 | CELSR3 | 1951 | 0 | 19 | 11 | |
| GSE43470 | CELSR3 | 1951 | 0 | 19 | 24 | |
| GSE46452 | CELSR3 | 1951 | 3 | 16 | 40 | |
| GSE47630 | CELSR3 | 1951 | 1 | 24 | 15 | |
| GSE54993 | CELSR3 | 1951 | 6 | 2 | 62 | |
| GSE54994 | CELSR3 | 1951 | 0 | 36 | 17 | |
| GSE60625 | CELSR3 | 1951 | 5 | 0 | 6 | |
| GSE74703 | CELSR3 | 1951 | 0 | 15 | 21 | |
| GSE74704 | CELSR3 | 1951 | 0 | 12 | 8 | |
| TCGA | CELSR3 | 1951 | 0 | 78 | 18 |
Total number of gains: 15; Total number of losses: 239; Total Number of normals: 234.
Somatic mutations of CELSR3:
Generating mutation plots.
Highly correlated genes for CELSR3:
Showing top 20/325 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CELSR3 | ARL9 | 0.7828 | 3 | 0 | 3 |
| CELSR3 | ARL8A | 0.708032 | 3 | 0 | 3 |
| CELSR3 | HRK | 0.668544 | 4 | 0 | 3 |
| CELSR3 | ASB6 | 0.662911 | 4 | 0 | 3 |
| CELSR3 | SFRP4 | 0.659562 | 4 | 0 | 3 |
| CELSR3 | KLRG2 | 0.657019 | 3 | 0 | 3 |
| CELSR3 | SLC45A3 | 0.656603 | 3 | 0 | 3 |
| CELSR3 | DVL2 | 0.656306 | 4 | 0 | 3 |
| CELSR3 | METTL2B | 0.654766 | 3 | 0 | 3 |
| CELSR3 | STK32C | 0.654658 | 4 | 0 | 3 |
| CELSR3 | RFX8 | 0.653314 | 3 | 0 | 3 |
| CELSR3 | BEND3 | 0.64417 | 7 | 0 | 7 |
| CELSR3 | CNGB3 | 0.64414 | 4 | 0 | 4 |
| CELSR3 | TBC1D13 | 0.64393 | 3 | 0 | 3 |
| CELSR3 | AGO2 | 0.641457 | 6 | 0 | 6 |
| CELSR3 | PSTK | 0.639966 | 4 | 0 | 3 |
| CELSR3 | ZNF593 | 0.638478 | 3 | 0 | 3 |
| CELSR3 | ZMYND15 | 0.635057 | 5 | 0 | 3 |
| CELSR3 | NAT14 | 0.629026 | 6 | 0 | 4 |
| CELSR3 | SRCAP | 0.626532 | 3 | 0 | 3 |
For details and further investigation, click here
