| Full name: secreted frizzled related protein 4 | Alias Symbol: frpHE|FRP-4|FRPHE|FRZB-2 | ||
| Type: protein-coding gene | Cytoband: 7p14.1 | ||
| Entrez ID: 6424 | HGNC ID: HGNC:10778 | Ensembl Gene: ENSG00000106483 | OMIM ID: 606570 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
SFRP4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway |
Expression of SFRP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SFRP4 | 6424 | 204051_s_at | 1.7679 | 0.2333 | |
| GSE20347 | SFRP4 | 6424 | 204051_s_at | 1.4156 | 0.0000 | |
| GSE23400 | SFRP4 | 6424 | 204051_s_at | 1.2194 | 0.0000 | |
| GSE26886 | SFRP4 | 6424 | 204051_s_at | 1.0509 | 0.0022 | |
| GSE29001 | SFRP4 | 6424 | 204051_s_at | 0.6211 | 0.0062 | |
| GSE38129 | SFRP4 | 6424 | 204051_s_at | 1.8504 | 0.0002 | |
| GSE45670 | SFRP4 | 6424 | 204051_s_at | -1.0339 | 0.0186 | |
| GSE53622 | SFRP4 | 6424 | 14294 | 3.0289 | 0.0000 | |
| GSE53624 | SFRP4 | 6424 | 14294 | 2.8416 | 0.0000 | |
| GSE63941 | SFRP4 | 6424 | 204051_s_at | -1.9921 | 0.0005 | |
| GSE77861 | SFRP4 | 6424 | 204051_s_at | 0.0626 | 0.4875 | |
| GSE97050 | SFRP4 | A_21_P0011967 | 0.7889 | 0.2615 | ||
| SRP007169 | SFRP4 | 6424 | RNAseq | 9.6358 | 0.0000 | |
| SRP008496 | SFRP4 | 6424 | RNAseq | 9.4696 | 0.0000 | |
| SRP064894 | SFRP4 | 6424 | RNAseq | 4.3985 | 0.0000 | |
| SRP133303 | SFRP4 | 6424 | RNAseq | 4.3395 | 0.0000 | |
| SRP159526 | SFRP4 | 6424 | RNAseq | 4.3867 | 0.0000 | |
| TCGA | SFRP4 | 6424 | RNAseq | 0.6914 | 0.0433 |
Upregulated datasets: 11; Downregulated datasets: 2.
Survival by SFRP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SFRP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SFRP4 | 6424 | 15 | 0 | 15 | |
| GSE20123 | SFRP4 | 6424 | 14 | 0 | 16 | |
| GSE43470 | SFRP4 | 6424 | 4 | 0 | 39 | |
| GSE46452 | SFRP4 | 6424 | 11 | 1 | 47 | |
| GSE47630 | SFRP4 | 6424 | 8 | 1 | 31 | |
| GSE54993 | SFRP4 | 6424 | 0 | 7 | 63 | |
| GSE54994 | SFRP4 | 6424 | 18 | 3 | 32 | |
| GSE60625 | SFRP4 | 6424 | 0 | 0 | 11 | |
| GSE74703 | SFRP4 | 6424 | 4 | 0 | 32 | |
| GSE74704 | SFRP4 | 6424 | 8 | 0 | 12 | |
| TCGA | SFRP4 | 6424 | 52 | 7 | 37 |
Total number of gains: 134; Total number of losses: 19; Total Number of normals: 335.
Somatic mutations of SFRP4:
Generating mutation plots.
Highly correlated genes for SFRP4:
Showing top 20/595 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SFRP4 | ITGA11 | 0.756628 | 4 | 0 | 4 |
| SFRP4 | ASPN | 0.745614 | 11 | 0 | 10 |
| SFRP4 | MRPS6 | 0.707324 | 3 | 0 | 3 |
| SFRP4 | ISLR | 0.681797 | 13 | 0 | 11 |
| SFRP4 | COL8A1 | 0.680779 | 9 | 0 | 9 |
| SFRP4 | FNDC1 | 0.679904 | 8 | 0 | 7 |
| SFRP4 | SULF1 | 0.663956 | 12 | 0 | 11 |
| SFRP4 | CELSR3 | 0.659562 | 4 | 0 | 3 |
| SFRP4 | ADAMTS16 | 0.657863 | 3 | 0 | 3 |
| SFRP4 | GALNT15 | 0.657758 | 4 | 0 | 3 |
| SFRP4 | SLC39A1 | 0.655434 | 4 | 0 | 4 |
| SFRP4 | AEBP1 | 0.653605 | 12 | 0 | 11 |
| SFRP4 | LOXL1 | 0.650367 | 13 | 0 | 11 |
| SFRP4 | MMP11 | 0.649599 | 9 | 0 | 9 |
| SFRP4 | PLXNC1 | 0.649269 | 9 | 0 | 8 |
| SFRP4 | VCAN | 0.649094 | 13 | 0 | 12 |
| SFRP4 | XPO5 | 0.647173 | 3 | 0 | 3 |
| SFRP4 | DACT1 | 0.64606 | 13 | 0 | 11 |
| SFRP4 | PTGFRN | 0.645121 | 4 | 0 | 3 |
| SFRP4 | RARRES2 | 0.64152 | 13 | 0 | 13 |
For details and further investigation, click here
