| Full name: carboxylesterase 3 | Alias Symbol: FLJ21736|ES31 | ||
| Type: protein-coding gene | Cytoband: 16q22.1 | ||
| Entrez ID: 23491 | HGNC ID: HGNC:1865 | Ensembl Gene: ENSG00000172828 | OMIM ID: 605279 |
| Drug and gene relationship at DGIdb | |||
Expression of CES3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CES3 | 23491 | 234008_s_at | 0.0481 | 0.8237 | |
| GSE20347 | CES3 | 23491 | 220335_x_at | 0.6285 | 0.0081 | |
| GSE23400 | CES3 | 23491 | 220335_x_at | -0.0138 | 0.8206 | |
| GSE26886 | CES3 | 23491 | 220335_x_at | -0.4217 | 0.0022 | |
| GSE29001 | CES3 | 23491 | 220335_x_at | -0.1294 | 0.5788 | |
| GSE38129 | CES3 | 23491 | 220335_x_at | 0.4130 | 0.0454 | |
| GSE45670 | CES3 | 23491 | 220335_x_at | 0.4324 | 0.0420 | |
| GSE53622 | CES3 | 23491 | 40822 | -0.0621 | 0.4270 | |
| GSE53624 | CES3 | 23491 | 40822 | 0.0004 | 0.9964 | |
| GSE63941 | CES3 | 23491 | 220335_x_at | 0.3864 | 0.3597 | |
| GSE77861 | CES3 | 23491 | 220335_x_at | 0.3702 | 0.0279 | |
| GSE97050 | CES3 | 23491 | A_24_P90881 | -0.0069 | 0.9774 | |
| SRP007169 | CES3 | 23491 | RNAseq | 0.1188 | 0.8809 | |
| SRP064894 | CES3 | 23491 | RNAseq | -0.9098 | 0.0029 | |
| SRP133303 | CES3 | 23491 | RNAseq | -0.7429 | 0.0000 | |
| SRP159526 | CES3 | 23491 | RNAseq | 0.2560 | 0.6013 | |
| SRP193095 | CES3 | 23491 | RNAseq | -0.4627 | 0.0979 | |
| SRP219564 | CES3 | 23491 | RNAseq | -1.3791 | 0.0496 | |
| TCGA | CES3 | 23491 | RNAseq | -0.0948 | 0.8154 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CES3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CES3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CES3 | 23491 | 8 | 2 | 20 | |
| GSE20123 | CES3 | 23491 | 8 | 2 | 20 | |
| GSE43470 | CES3 | 23491 | 1 | 9 | 33 | |
| GSE46452 | CES3 | 23491 | 38 | 1 | 20 | |
| GSE47630 | CES3 | 23491 | 10 | 8 | 22 | |
| GSE54993 | CES3 | 23491 | 2 | 4 | 64 | |
| GSE54994 | CES3 | 23491 | 8 | 10 | 35 | |
| GSE60625 | CES3 | 23491 | 4 | 0 | 7 | |
| GSE74703 | CES3 | 23491 | 1 | 6 | 29 | |
| GSE74704 | CES3 | 23491 | 5 | 1 | 14 | |
| TCGA | CES3 | 23491 | 31 | 11 | 54 |
Total number of gains: 116; Total number of losses: 54; Total Number of normals: 318.
Somatic mutations of CES3:
Generating mutation plots.
Highly correlated genes for CES3:
Showing top 20/137 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CES3 | C9orf106 | 0.749478 | 3 | 0 | 3 |
| CES3 | FAM181A | 0.747684 | 3 | 0 | 3 |
| CES3 | POMT2 | 0.74626 | 3 | 0 | 3 |
| CES3 | JMJD8 | 0.743539 | 3 | 0 | 3 |
| CES3 | AANAT | 0.743356 | 3 | 0 | 3 |
| CES3 | DRGX | 0.73778 | 3 | 0 | 3 |
| CES3 | SHISA7 | 0.727884 | 3 | 0 | 3 |
| CES3 | SMOC1 | 0.718674 | 3 | 0 | 3 |
| CES3 | LRRIQ3 | 0.707885 | 3 | 0 | 3 |
| CES3 | LHFPL5 | 0.694123 | 3 | 0 | 3 |
| CES3 | KLRG2 | 0.693346 | 4 | 0 | 4 |
| CES3 | SNED1 | 0.689838 | 4 | 0 | 3 |
| CES3 | CNOT3 | 0.688563 | 3 | 0 | 3 |
| CES3 | GHRHR | 0.677706 | 4 | 0 | 3 |
| CES3 | PAX6 | 0.673598 | 4 | 0 | 3 |
| CES3 | SALL3 | 0.671929 | 3 | 0 | 3 |
| CES3 | ADAP1 | 0.667087 | 4 | 0 | 4 |
| CES3 | KRTAP6-1 | 0.665835 | 3 | 0 | 3 |
| CES3 | CCNL2 | 0.661646 | 5 | 0 | 5 |
| CES3 | PARS2 | 0.659608 | 3 | 0 | 3 |
For details and further investigation, click here
