| Full name: N-terminal Xaa-Pro-Lys N-methyltransferase 1 | Alias Symbol: AD-003|HOMT1A|NRMT1|NRMT | ||
| Type: protein-coding gene | Cytoband: 9q34.11 | ||
| Entrez ID: 28989 | HGNC ID: HGNC:23373 | Ensembl Gene: ENSG00000148335 | OMIM ID: 613560 |
| Drug and gene relationship at DGIdb | |||
Expression of NTMT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NTMT1 | 28989 | 223368_s_at | 0.6092 | 0.0481 | |
| GSE26886 | NTMT1 | 28989 | 223368_s_at | 1.0466 | 0.0000 | |
| GSE45670 | NTMT1 | 28989 | 223368_s_at | 0.6734 | 0.0003 | |
| GSE53622 | NTMT1 | 28989 | 101972 | 0.9392 | 0.0000 | |
| GSE53624 | NTMT1 | 28989 | 101972 | 1.0747 | 0.0000 | |
| GSE63941 | NTMT1 | 28989 | 223368_s_at | -0.2129 | 0.6535 | |
| GSE77861 | NTMT1 | 28989 | 223368_s_at | 0.3891 | 0.0289 | |
| SRP007169 | NTMT1 | 28989 | RNAseq | 1.0876 | 0.0220 | |
| SRP008496 | NTMT1 | 28989 | RNAseq | 1.1986 | 0.0003 | |
| SRP064894 | NTMT1 | 28989 | RNAseq | 1.1733 | 0.0005 | |
| SRP133303 | NTMT1 | 28989 | RNAseq | 0.7547 | 0.0000 | |
| SRP159526 | NTMT1 | 28989 | RNAseq | 0.7116 | 0.0036 | |
| SRP193095 | NTMT1 | 28989 | RNAseq | 0.6971 | 0.0000 | |
| SRP219564 | NTMT1 | 28989 | RNAseq | 0.1587 | 0.6953 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by NTMT1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of NTMT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NTMT1 | 28989 | 6 | 9 | 15 | |
| GSE20123 | NTMT1 | 28989 | 6 | 9 | 15 | |
| GSE43470 | NTMT1 | 28989 | 5 | 8 | 30 | |
| GSE46452 | NTMT1 | 28989 | 6 | 13 | 40 | |
| GSE47630 | NTMT1 | 28989 | 3 | 16 | 21 | |
| GSE54993 | NTMT1 | 28989 | 3 | 3 | 64 | |
| GSE54994 | NTMT1 | 28989 | 12 | 9 | 32 | |
| GSE60625 | NTMT1 | 28989 | 0 | 0 | 11 | |
| GSE74703 | NTMT1 | 28989 | 5 | 6 | 25 | |
| GSE74704 | NTMT1 | 28989 | 3 | 7 | 10 | |
| TCGA | NTMT1 | 28989 | 27 | 26 | 43 |
Total number of gains: 76; Total number of losses: 106; Total Number of normals: 306.
Somatic mutations of NTMT1:
Generating mutation plots.
Highly correlated genes for NTMT1:
Showing top 20/1669 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NTMT1 | STC2 | 0.806633 | 6 | 0 | 6 |
| NTMT1 | MRPS17 | 0.796192 | 3 | 0 | 3 |
| NTMT1 | KNSTRN | 0.780748 | 5 | 0 | 5 |
| NTMT1 | PSMB2 | 0.776581 | 6 | 0 | 6 |
| NTMT1 | CMSS1 | 0.762066 | 6 | 0 | 6 |
| NTMT1 | IMP4 | 0.759398 | 6 | 0 | 6 |
| NTMT1 | WDR54 | 0.758185 | 6 | 0 | 6 |
| NTMT1 | HOMER3 | 0.757329 | 6 | 0 | 6 |
| NTMT1 | PSMB3 | 0.753581 | 5 | 0 | 5 |
| NTMT1 | TRIP13 | 0.752921 | 5 | 0 | 5 |
| NTMT1 | CHCHD2 | 0.751542 | 4 | 0 | 4 |
| NTMT1 | ZNF598 | 0.751252 | 3 | 0 | 3 |
| NTMT1 | WDHD1 | 0.747964 | 6 | 0 | 6 |
| NTMT1 | PLAU | 0.74785 | 6 | 0 | 6 |
| NTMT1 | LAMC2 | 0.746322 | 6 | 0 | 5 |
| NTMT1 | AUNIP | 0.746068 | 5 | 0 | 5 |
| NTMT1 | CKS2 | 0.741912 | 5 | 0 | 5 |
| NTMT1 | MRPS2 | 0.740952 | 5 | 0 | 5 |
| NTMT1 | ATP6V1C1 | 0.740325 | 5 | 0 | 5 |
| NTMT1 | KDM1A | 0.74009 | 4 | 0 | 4 |
For details and further investigation, click here
