| Full name: choline kinase beta | Alias Symbol: CHETK | ||
| Type: protein-coding gene | Cytoband: 22q13.33 | ||
| Entrez ID: 1120 | HGNC ID: HGNC:1938 | Ensembl Gene: ENSG00000100288 | OMIM ID: 612395 |
| Drug and gene relationship at DGIdb | |||
CHKB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05231 | Choline metabolism in cancer |
Expression of CHKB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHKB | 1120 | 204193_at | -0.3431 | 0.4402 | |
| GSE20347 | CHKB | 1120 | 204193_at | -0.5879 | 0.0001 | |
| GSE23400 | CHKB | 1120 | 204193_at | -0.2848 | 0.0000 | |
| GSE26886 | CHKB | 1120 | 204193_at | -0.0415 | 0.8526 | |
| GSE29001 | CHKB | 1120 | 204193_at | -0.2782 | 0.2928 | |
| GSE38129 | CHKB | 1120 | 204193_at | -0.5178 | 0.0000 | |
| GSE45670 | CHKB | 1120 | 204193_at | -0.2494 | 0.1331 | |
| GSE53622 | CHKB | 1120 | 126251 | 0.1967 | 0.0076 | |
| GSE53624 | CHKB | 1120 | 126251 | -0.3263 | 0.0002 | |
| GSE63941 | CHKB | 1120 | 204193_at | -0.3322 | 0.5316 | |
| GSE77861 | CHKB | 1120 | 204193_at | -0.1412 | 0.2517 | |
| GSE97050 | CHKB | 1120 | A_23_P314120 | 0.2856 | 0.2102 | |
| SRP007169 | CHKB | 1120 | RNAseq | -1.3286 | 0.0011 | |
| SRP008496 | CHKB | 1120 | RNAseq | -0.9883 | 0.0006 | |
| SRP064894 | CHKB | 1120 | RNAseq | 0.5052 | 0.0122 | |
| SRP133303 | CHKB | 1120 | RNAseq | -0.3195 | 0.0156 | |
| SRP159526 | CHKB | 1120 | RNAseq | -0.1545 | 0.6618 | |
| SRP193095 | CHKB | 1120 | RNAseq | 0.0373 | 0.7994 | |
| SRP219564 | CHKB | 1120 | RNAseq | -0.1292 | 0.4876 | |
| TCGA | CHKB | 1120 | RNAseq | -0.1912 | 0.0331 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CHKB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHKB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHKB | 1120 | 3 | 8 | 19 | |
| GSE20123 | CHKB | 1120 | 3 | 8 | 19 | |
| GSE43470 | CHKB | 1120 | 2 | 8 | 33 | |
| GSE46452 | CHKB | 1120 | 31 | 2 | 26 | |
| GSE47630 | CHKB | 1120 | 9 | 4 | 27 | |
| GSE54993 | CHKB | 1120 | 4 | 6 | 60 | |
| GSE54994 | CHKB | 1120 | 11 | 8 | 34 | |
| GSE60625 | CHKB | 1120 | 5 | 0 | 6 | |
| GSE74703 | CHKB | 1120 | 2 | 6 | 28 | |
| GSE74704 | CHKB | 1120 | 1 | 4 | 15 | |
| TCGA | CHKB | 1120 | 26 | 16 | 54 |
Total number of gains: 97; Total number of losses: 70; Total Number of normals: 321.
Somatic mutations of CHKB:
Generating mutation plots.
Highly correlated genes for CHKB:
Showing top 20/60 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHKB | SH3BP5-AS1 | 0.659551 | 3 | 0 | 3 |
| CHKB | GAS2 | 0.602478 | 5 | 0 | 4 |
| CHKB | D2HGDH | 0.600208 | 4 | 0 | 4 |
| CHKB | EVI2A | 0.596886 | 3 | 0 | 3 |
| CHKB | TRIM29 | 0.58935 | 3 | 0 | 3 |
| CHKB | RBM5 | 0.581405 | 6 | 0 | 6 |
| CHKB | PIK3C2G | 0.575497 | 5 | 0 | 3 |
| CHKB | KRT15 | 0.569566 | 4 | 0 | 3 |
| CHKB | MRPL22 | 0.568109 | 4 | 0 | 4 |
| CHKB | ARSF | 0.562867 | 5 | 0 | 4 |
| CHKB | TPCN1 | 0.561077 | 6 | 0 | 4 |
| CHKB | ALAD | 0.5575 | 6 | 0 | 4 |
| CHKB | CHMP2A | 0.55413 | 4 | 0 | 3 |
| CHKB | MAX | 0.553188 | 4 | 0 | 3 |
| CHKB | MAP3K6 | 0.551595 | 7 | 0 | 5 |
| CHKB | C11orf80 | 0.54956 | 4 | 0 | 3 |
| CHKB | LINC01315 | 0.547601 | 4 | 0 | 3 |
| CHKB | ATP8B4 | 0.547576 | 3 | 0 | 3 |
| CHKB | SMDT1 | 0.547406 | 6 | 0 | 4 |
| CHKB | PPDPF | 0.544522 | 5 | 0 | 3 |
For details and further investigation, click here
