| Full name: cholinergic receptor nicotinic alpha 5 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q25.1 | ||
| Entrez ID: 1138 | HGNC ID: HGNC:1959 | Ensembl Gene: ENSG00000169684 | OMIM ID: 118505 |
| Drug and gene relationship at DGIdb | |||
Expression of CHRNA5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHRNA5 | 1138 | 206533_at | 1.1575 | 0.0865 | |
| GSE20347 | CHRNA5 | 1138 | 206533_at | 0.4912 | 0.0002 | |
| GSE23400 | CHRNA5 | 1138 | 206533_at | 0.1186 | 0.0088 | |
| GSE26886 | CHRNA5 | 1138 | 206533_at | 0.1378 | 0.4364 | |
| GSE29001 | CHRNA5 | 1138 | 206533_at | 0.2827 | 0.1149 | |
| GSE38129 | CHRNA5 | 1138 | 206533_at | 0.6167 | 0.0000 | |
| GSE45670 | CHRNA5 | 1138 | 206533_at | 0.7684 | 0.0382 | |
| GSE63941 | CHRNA5 | 1138 | 206533_at | 2.8366 | 0.0012 | |
| GSE77861 | CHRNA5 | 1138 | 206533_at | 0.2360 | 0.1202 | |
| GSE97050 | CHRNA5 | 1138 | A_23_P88691 | 0.5094 | 0.2727 | |
| SRP007169 | CHRNA5 | 1138 | RNAseq | 0.2701 | 0.6019 | |
| SRP008496 | CHRNA5 | 1138 | RNAseq | 0.6414 | 0.1197 | |
| SRP064894 | CHRNA5 | 1138 | RNAseq | 1.3917 | 0.0000 | |
| SRP133303 | CHRNA5 | 1138 | RNAseq | 0.9480 | 0.0203 | |
| SRP159526 | CHRNA5 | 1138 | RNAseq | 1.7933 | 0.0000 | |
| SRP193095 | CHRNA5 | 1138 | RNAseq | 0.7201 | 0.0000 | |
| SRP219564 | CHRNA5 | 1138 | RNAseq | 0.9497 | 0.1233 | |
| TCGA | CHRNA5 | 1138 | RNAseq | 0.8332 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by CHRNA5 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CHRNA5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHRNA5 | 1138 | 7 | 1 | 22 | |
| GSE20123 | CHRNA5 | 1138 | 7 | 1 | 22 | |
| GSE43470 | CHRNA5 | 1138 | 4 | 5 | 34 | |
| GSE46452 | CHRNA5 | 1138 | 3 | 7 | 49 | |
| GSE47630 | CHRNA5 | 1138 | 8 | 10 | 22 | |
| GSE54993 | CHRNA5 | 1138 | 5 | 6 | 59 | |
| GSE54994 | CHRNA5 | 1138 | 5 | 6 | 42 | |
| GSE60625 | CHRNA5 | 1138 | 4 | 0 | 7 | |
| GSE74703 | CHRNA5 | 1138 | 4 | 3 | 29 | |
| GSE74704 | CHRNA5 | 1138 | 3 | 1 | 16 | |
| TCGA | CHRNA5 | 1138 | 14 | 15 | 67 |
Total number of gains: 64; Total number of losses: 55; Total Number of normals: 369.
Somatic mutations of CHRNA5:
Generating mutation plots.
Highly correlated genes for CHRNA5:
Showing top 20/488 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHRNA5 | QRFPR | 0.763668 | 4 | 0 | 4 |
| CHRNA5 | RCCD1 | 0.73468 | 4 | 0 | 4 |
| CHRNA5 | IL1B | 0.722783 | 3 | 0 | 3 |
| CHRNA5 | UBL7-AS1 | 0.713862 | 3 | 0 | 3 |
| CHRNA5 | TUBG1 | 0.710028 | 6 | 0 | 6 |
| CHRNA5 | GINS2 | 0.70529 | 8 | 0 | 7 |
| CHRNA5 | CDCA5 | 0.703899 | 5 | 0 | 4 |
| CHRNA5 | CDC6 | 0.70344 | 9 | 0 | 8 |
| CHRNA5 | USP49 | 0.699345 | 3 | 0 | 3 |
| CHRNA5 | CKAP2L | 0.698548 | 4 | 0 | 4 |
| CHRNA5 | ZNF488 | 0.693571 | 4 | 0 | 4 |
| CHRNA5 | STRIP2 | 0.683194 | 3 | 0 | 3 |
| CHRNA5 | EXO1 | 0.6824 | 9 | 0 | 7 |
| CHRNA5 | PABPC1L | 0.680976 | 3 | 0 | 3 |
| CHRNA5 | RAD51 | 0.678992 | 10 | 0 | 8 |
| CHRNA5 | KNSTRN | 0.676692 | 4 | 0 | 3 |
| CHRNA5 | MTHFD2 | 0.673719 | 6 | 0 | 5 |
| CHRNA5 | GPR4 | 0.671273 | 5 | 0 | 4 |
| CHRNA5 | PTRH2 | 0.669942 | 6 | 0 | 6 |
| CHRNA5 | AUNIP | 0.665785 | 8 | 0 | 7 |
For details and further investigation, click here
