RAD51

 

Full name: RAD51 recombinase Alias Symbol: HsRad51|HsT16930|BRCC5|FANCR
Type: protein-coding gene Cytoband: 15q15.1
Entrez ID: 5888 HGNC ID: HGNC:9817 Ensembl Gene: ENSG00000051180 OMIM ID: 179617
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

RAD51 involved pathways:

KEGG pathway Description View
hsa03460Fanconi anemia pathway

 

Expression of RAD51:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RAD51 5888 205024_s_at 1.1834 0.0868
GSE20347 RAD51 5888 205024_s_at 1.2507 0.0000
GSE23400 RAD51 5888 205024_s_at 0.5507 0.0000
GSE26886 RAD51 5888 205024_s_at 0.8751 0.0014
GSE29001 RAD51 5888 205024_s_at 1.3485 0.0016
GSE38129 RAD51 5888 205024_s_at 1.4218 0.0000
GSE45670 RAD51 5888 205024_s_at 1.1664 0.0001
GSE53622 RAD51 5888 18268 1.0276 0.0000
GSE53624 RAD51 5888 18268 1.3253 0.0000
GSE63941 RAD51 5888 205024_s_at 2.2361 0.0004
GSE77861 RAD51 5888 205024_s_at 0.5759 0.0716
GSE97050 RAD51 5888 A_23_P88731 0.4805 0.2152
SRP007169 RAD51 5888 RNAseq 1.8843 0.0003
SRP064894 RAD51 5888 RNAseq 1.4513 0.0000
SRP133303 RAD51 5888 RNAseq 1.0830 0.0000
SRP159526 RAD51 5888 RNAseq 1.3831 0.0000
SRP193095 RAD51 5888 RNAseq 0.7480 0.0000
SRP219564 RAD51 5888 RNAseq 1.6268 0.0019
TCGA RAD51 5888 RNAseq 1.3386 0.0000

Upregulated datasets: 13; Downregulated datasets: 0.  

 

Survival by RAD51 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RAD51:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RAD51 5888 3 6 21
GSE20123 RAD51 5888 3 6 21
GSE43470 RAD51 5888 4 6 33
GSE46452 RAD51 5888 3 7 49
GSE47630 RAD51 5888 8 11 21
GSE54993 RAD51 5888 4 6 60
GSE54994 RAD51 5888 5 7 41
GSE60625 RAD51 5888 4 0 7
GSE74703 RAD51 5888 4 5 27
GSE74704 RAD51 5888 2 4 14
TCGA RAD51 5888 11 18 67

Total number of gains: 51; Total number of losses: 76; Total Number of normals: 361.  

 

Somatic mutations of RAD51:

 

Generating mutation plots.

 

Highly correlated genes for RAD51:

 

Showing top 20/547 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RAD51CDCA50.88853808
RAD51KNSTRN0.87948707
RAD51CDC60.85035710010
RAD51AURKB0.83697911011
RAD51GINS20.83573112012
RAD51TRIP130.82989111011
RAD51CDC450.82833211011
RAD51CDC200.82716512012
RAD51FEN10.82327210010
RAD51FANCI0.82118211011
RAD51CENPN0.81343111011
RAD51CDK10.81331911011
RAD51MTFR20.805538707
RAD51KIF2C0.80416511011
RAD51KIF140.80274311011
RAD51MYBL20.7996811011
RAD51EXO10.79854912011
RAD51CENPF0.79541211011
RAD51CDCA80.78938712012
RAD51MCM70.7886912012

For details and further investigation, click here