EXO1

 

Full name: exonuclease 1 Alias Symbol: HEX1|hExoI
Type: protein-coding gene Cytoband: 1q43
Entrez ID: 9156 HGNC ID: HGNC:3511 Ensembl Gene: ENSG00000174371 OMIM ID: 606063
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of EXO1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 EXO1 9156 204603_at 1.4908 0.0155
GSE20347 EXO1 9156 204603_at 1.1339 0.0000
GSE23400 EXO1 9156 204603_at 0.3909 0.0000
GSE26886 EXO1 9156 204603_at 0.5867 0.0004
GSE29001 EXO1 9156 204603_at 0.7751 0.0017
GSE38129 EXO1 9156 204603_at 1.5694 0.0000
GSE45670 EXO1 9156 204603_at 1.8668 0.0000
GSE53622 EXO1 9156 748 1.3176 0.0000
GSE53624 EXO1 9156 748 1.8622 0.0000
GSE63941 EXO1 9156 204603_at 3.0842 0.0000
GSE77861 EXO1 9156 204603_at 0.6265 0.0064
GSE97050 EXO1 9156 A_23_P23303 1.1447 0.1726
SRP007169 EXO1 9156 RNAseq 1.8098 0.0000
SRP008496 EXO1 9156 RNAseq 1.5465 0.0004
SRP064894 EXO1 9156 RNAseq 1.5774 0.0000
SRP133303 EXO1 9156 RNAseq 1.9161 0.0000
SRP159526 EXO1 9156 RNAseq 1.9354 0.0000
SRP193095 EXO1 9156 RNAseq 1.3678 0.0000
SRP219564 EXO1 9156 RNAseq 2.3354 0.0015
TCGA EXO1 9156 RNAseq 1.5978 0.0000

Upregulated datasets: 15; Downregulated datasets: 0.  

 

Survival by EXO1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of EXO1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 EXO1 9156 6 1 23
GSE20123 EXO1 9156 6 1 23
GSE43470 EXO1 9156 6 1 36
GSE46452 EXO1 9156 4 2 53
GSE47630 EXO1 9156 15 0 25
GSE54993 EXO1 9156 0 6 64
GSE54994 EXO1 9156 18 0 35
GSE60625 EXO1 9156 0 0 11
GSE74703 EXO1 9156 6 1 29
GSE74704 EXO1 9156 2 0 18
TCGA EXO1 9156 43 4 49

Total number of gains: 106; Total number of losses: 16; Total Number of normals: 366.  

 

Somatic mutations of EXO1:

 

Generating mutation plots.

 

Highly correlated genes for EXO1:

 

Showing top 20/1349 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
EXO1NCAPH0.838424909
EXO1NUF20.834207808
EXO1BOP10.831158303
EXO1DTL0.8236712012
EXO1SKA30.821563606
EXO1CDK10.81876711011
EXO1NEK20.8138112011
EXO1MYBL20.81161712012
EXO1MCM20.80927513013
EXO1CDC450.80464712012
EXO1BLM0.8045212012
EXO1RAD51AP10.80442413013
EXO1CDC60.80401810010
EXO1CDCA30.80220412011
EXO1GMNN0.80012912012
EXO1MCM100.7996211011
EXO1C1orf1120.79944310010
EXO1KNSTRN0.798932707
EXO1RAD510.79854912011
EXO1UBE2T0.798016908

For details and further investigation, click here