GINS2

 

Full name: GINS complex subunit 2 Alias Symbol: PSF2|Pfs2
Type: protein-coding gene Cytoband: 16q24.1
Entrez ID: 51659 HGNC ID: HGNC:24575 Ensembl Gene: ENSG00000131153 OMIM ID: 610609
Drug and gene relationship at DGIdb

 

Expression of GINS2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GINS2 51659 221521_s_at 1.1031 0.0370
GSE20347 GINS2 51659 221521_s_at 1.5111 0.0000
GSE23400 GINS2 51659 221521_s_at 0.9718 0.0000
GSE26886 GINS2 51659 221521_s_at 1.3120 0.0015
GSE29001 GINS2 51659 221521_s_at 1.2310 0.0066
GSE38129 GINS2 51659 221521_s_at 1.8986 0.0000
GSE45670 GINS2 51659 221521_s_at 1.1308 0.0007
GSE53622 GINS2 51659 409 1.5892 0.0000
GSE53624 GINS2 51659 409 1.6697 0.0000
GSE63941 GINS2 51659 221521_s_at 3.7217 0.0000
GSE77861 GINS2 51659 221521_s_at 1.1786 0.0010
GSE97050 GINS2 51659 A_23_P118246 1.0625 0.1389
SRP007169 GINS2 51659 RNAseq 2.0837 0.0000
SRP008496 GINS2 51659 RNAseq 1.8168 0.0001
SRP064894 GINS2 51659 RNAseq 1.3391 0.0001
SRP133303 GINS2 51659 RNAseq 1.3929 0.0000
SRP159526 GINS2 51659 RNAseq 1.7999 0.0000
SRP193095 GINS2 51659 RNAseq 0.9166 0.0000
SRP219564 GINS2 51659 RNAseq 1.8318 0.0058
TCGA GINS2 51659 RNAseq 1.2783 0.0000

Upregulated datasets: 17; Downregulated datasets: 0.  

 

Survival by GINS2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GINS2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GINS2 51659 4 4 22
GSE20123 GINS2 51659 4 4 22
GSE43470 GINS2 51659 2 10 31
GSE46452 GINS2 51659 37 2 20
GSE47630 GINS2 51659 11 9 20
GSE54993 GINS2 51659 3 4 63
GSE54994 GINS2 51659 9 10 34
GSE60625 GINS2 51659 4 0 7
GSE74703 GINS2 51659 1 7 28
GSE74704 GINS2 51659 3 2 15
TCGA GINS2 51659 26 17 53

Total number of gains: 104; Total number of losses: 69; Total Number of normals: 315.  

 

Somatic mutations of GINS2:

 

Generating mutation plots.

 

Highly correlated genes for GINS2:

 

Showing top 20/897 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GINS2MCM20.84554713013
GINS2MCM50.83820811011
GINS2RAD510.83573112012
GINS2DTL0.82901912012
GINS2CDC60.82621910010
GINS2CENPN0.82524212012
GINS2CDC200.82308512012
GINS2GINS10.82263111011
GINS2KIF4A0.81849113012
GINS2MYBL20.81705811011
GINS2TK10.81657713012
GINS2ORC60.81201312012
GINS2CENPM0.80605512012
GINS2FEN10.80471711010
GINS2KIF18B0.80224911011
GINS2BUB1B0.8019411010
GINS2UBE2C0.80083112012
GINS2CDCA50.798989908
GINS2CDC450.79556512012
GINS2EXO10.79359113012

For details and further investigation, click here