| Full name: VPS52 subunit of GARP complex | Alias Symbol: ARE1 | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 6293 | HGNC ID: HGNC:10518 | Ensembl Gene: ENSG00000223501 | OMIM ID: 603443 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of VPS52:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS52 | 6293 | 214585_s_at | -0.0373 | 0.9494 | |
| GSE20347 | VPS52 | 6293 | 214585_s_at | -0.2237 | 0.0089 | |
| GSE23400 | VPS52 | 6293 | 214585_s_at | -0.0835 | 0.0379 | |
| GSE26886 | VPS52 | 6293 | 214585_s_at | -0.2944 | 0.0905 | |
| GSE29001 | VPS52 | 6293 | 214585_s_at | -0.4495 | 0.0433 | |
| GSE38129 | VPS52 | 6293 | 214585_s_at | -0.1757 | 0.0247 | |
| GSE45670 | VPS52 | 6293 | 214585_s_at | -0.0987 | 0.3594 | |
| GSE53622 | VPS52 | 6293 | 5253 | -0.6505 | 0.0000 | |
| GSE53624 | VPS52 | 6293 | 5253 | -0.7351 | 0.0000 | |
| GSE63941 | VPS52 | 6293 | 214585_s_at | 0.5027 | 0.0534 | |
| GSE77861 | VPS52 | 6293 | 214585_s_at | -0.4527 | 0.0025 | |
| GSE97050 | VPS52 | 6293 | A_23_P70583 | -0.0301 | 0.9349 | |
| SRP007169 | VPS52 | 6293 | RNAseq | -0.8679 | 0.0301 | |
| SRP008496 | VPS52 | 6293 | RNAseq | -1.1212 | 0.0000 | |
| SRP064894 | VPS52 | 6293 | RNAseq | -0.2357 | 0.1015 | |
| SRP133303 | VPS52 | 6293 | RNAseq | -0.5636 | 0.0021 | |
| SRP159526 | VPS52 | 6293 | RNAseq | -0.4051 | 0.0208 | |
| SRP193095 | VPS52 | 6293 | RNAseq | -0.4907 | 0.0000 | |
| SRP219564 | VPS52 | 6293 | RNAseq | -0.0269 | 0.9310 | |
| TCGA | VPS52 | 6293 | RNAseq | -0.0285 | 0.5385 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by VPS52 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS52:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS52 | 6293 | 5 | 0 | 25 | |
| GSE20123 | VPS52 | 6293 | 5 | 0 | 25 | |
| GSE43470 | VPS52 | 6293 | 4 | 1 | 38 | |
| GSE46452 | VPS52 | 6293 | 2 | 9 | 48 | |
| GSE47630 | VPS52 | 6293 | 8 | 4 | 28 | |
| GSE54993 | VPS52 | 6293 | 3 | 1 | 66 | |
| GSE54994 | VPS52 | 6293 | 11 | 4 | 38 | |
| GSE60625 | VPS52 | 6293 | 1 | 0 | 10 | |
| GSE74703 | VPS52 | 6293 | 4 | 0 | 32 | |
| GSE74704 | VPS52 | 6293 | 2 | 0 | 18 | |
| TCGA | VPS52 | 6293 | 15 | 16 | 65 |
Total number of gains: 60; Total number of losses: 35; Total Number of normals: 393.
Somatic mutations of VPS52:
Generating mutation plots.
Highly correlated genes for VPS52:
Showing top 20/950 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS52 | RABEP2 | 0.771114 | 5 | 0 | 4 |
| VPS52 | SPPL3 | 0.767623 | 3 | 0 | 3 |
| VPS52 | KCNK13 | 0.743518 | 3 | 0 | 3 |
| VPS52 | RRAGC | 0.740208 | 3 | 0 | 3 |
| VPS52 | CD22 | 0.737926 | 3 | 0 | 3 |
| VPS52 | ACVRL1 | 0.731889 | 3 | 0 | 3 |
| VPS52 | CHRNB1 | 0.726394 | 3 | 0 | 3 |
| VPS52 | TAS2R4 | 0.713125 | 3 | 0 | 3 |
| VPS52 | GIT1 | 0.709481 | 3 | 0 | 3 |
| VPS52 | OR7E24 | 0.70731 | 3 | 0 | 3 |
| VPS52 | WARS2 | 0.705145 | 3 | 0 | 3 |
| VPS52 | TMCO4 | 0.704325 | 5 | 0 | 4 |
| VPS52 | ALDH5A1 | 0.699885 | 3 | 0 | 3 |
| VPS52 | SYT17 | 0.699361 | 3 | 0 | 3 |
| VPS52 | ZNF600 | 0.698495 | 3 | 0 | 3 |
| VPS52 | LRTOMT | 0.695664 | 3 | 0 | 3 |
| VPS52 | PPCS | 0.693817 | 5 | 0 | 4 |
| VPS52 | CCNYL1 | 0.692433 | 4 | 0 | 3 |
| VPS52 | DVL1 | 0.689194 | 5 | 0 | 4 |
| VPS52 | CCNDBP1 | 0.688152 | 4 | 0 | 4 |
For details and further investigation, click here
