| Full name: BUB1 mitotic checkpoint serine/threonine kinase | Alias Symbol: hBUB1|BUB1A | ||
| Type: protein-coding gene | Cytoband: 2q13 | ||
| Entrez ID: 699 | HGNC ID: HGNC:1148 | Ensembl Gene: ENSG00000169679 | OMIM ID: 602452 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
BUB1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle | |
| hsa04114 | Oocyte meiosis | |
| hsa04914 | Progesterone-mediated oocyte maturation |
Expression of BUB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BUB1 | 699 | 209642_at | 2.1792 | 0.0250 | |
| GSE20347 | BUB1 | 699 | 209642_at | 2.1461 | 0.0000 | |
| GSE23400 | BUB1 | 699 | 216275_at | -0.0987 | 0.0131 | |
| GSE26886 | BUB1 | 699 | 209642_at | 0.7956 | 0.0518 | |
| GSE29001 | BUB1 | 699 | 216275_at | 0.1257 | 0.5462 | |
| GSE38129 | BUB1 | 699 | 209642_at | 2.6003 | 0.0000 | |
| GSE45670 | BUB1 | 699 | 209642_at | 2.0701 | 0.0000 | |
| GSE53622 | BUB1 | 699 | 39990 | 1.8480 | 0.0000 | |
| GSE53624 | BUB1 | 699 | 39990 | 2.2638 | 0.0000 | |
| GSE63941 | BUB1 | 699 | 209642_at | 3.0387 | 0.0007 | |
| GSE77861 | BUB1 | 699 | 209642_at | 1.4939 | 0.0006 | |
| GSE97050 | BUB1 | 699 | A_23_P124417 | 1.4533 | 0.0594 | |
| SRP007169 | BUB1 | 699 | RNAseq | 1.9193 | 0.0000 | |
| SRP008496 | BUB1 | 699 | RNAseq | 1.7816 | 0.0000 | |
| SRP064894 | BUB1 | 699 | RNAseq | 1.7364 | 0.0000 | |
| SRP133303 | BUB1 | 699 | RNAseq | 1.7899 | 0.0000 | |
| SRP159526 | BUB1 | 699 | RNAseq | 1.3670 | 0.0006 | |
| SRP193095 | BUB1 | 699 | RNAseq | 1.0101 | 0.0000 | |
| SRP219564 | BUB1 | 699 | RNAseq | 0.9866 | 0.1502 | |
| TCGA | BUB1 | 699 | RNAseq | 1.3265 | 0.0000 |
Upregulated datasets: 15; Downregulated datasets: 0.
Survival by BUB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BUB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BUB1 | 699 | 4 | 2 | 24 | |
| GSE20123 | BUB1 | 699 | 4 | 2 | 24 | |
| GSE43470 | BUB1 | 699 | 3 | 1 | 39 | |
| GSE46452 | BUB1 | 699 | 1 | 4 | 54 | |
| GSE47630 | BUB1 | 699 | 7 | 0 | 33 | |
| GSE54993 | BUB1 | 699 | 0 | 6 | 64 | |
| GSE54994 | BUB1 | 699 | 10 | 0 | 43 | |
| GSE60625 | BUB1 | 699 | 0 | 3 | 8 | |
| GSE74703 | BUB1 | 699 | 3 | 1 | 32 | |
| GSE74704 | BUB1 | 699 | 2 | 2 | 16 | |
| TCGA | BUB1 | 699 | 32 | 5 | 59 |
Total number of gains: 66; Total number of losses: 26; Total Number of normals: 396.
Somatic mutations of BUB1:
Generating mutation plots.
Highly correlated genes for BUB1:
Showing top 20/1562 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BUB1 | NCAPH | 0.918518 | 7 | 0 | 7 |
| BUB1 | FOXM1 | 0.877207 | 9 | 0 | 9 |
| BUB1 | ASPM | 0.857902 | 11 | 0 | 11 |
| BUB1 | SPAG5 | 0.857829 | 11 | 0 | 11 |
| BUB1 | TOP2A | 0.855606 | 11 | 0 | 11 |
| BUB1 | DLGAP5 | 0.853395 | 10 | 0 | 10 |
| BUB1 | NUF2 | 0.852456 | 9 | 0 | 9 |
| BUB1 | CDCA3 | 0.851588 | 11 | 0 | 11 |
| BUB1 | CDKN3 | 0.850359 | 11 | 0 | 11 |
| BUB1 | CEP55 | 0.850252 | 11 | 0 | 11 |
| BUB1 | KIF18A | 0.845865 | 11 | 0 | 11 |
| BUB1 | TPX2 | 0.844821 | 11 | 0 | 11 |
| BUB1 | UBE2C | 0.844611 | 11 | 0 | 11 |
| BUB1 | BIRC5 | 0.844284 | 10 | 0 | 10 |
| BUB1 | NEK2 | 0.842367 | 11 | 0 | 11 |
| BUB1 | KIF18B | 0.841554 | 9 | 0 | 9 |
| BUB1 | TTK | 0.839309 | 11 | 0 | 10 |
| BUB1 | KIF20A | 0.837781 | 11 | 0 | 11 |
| BUB1 | ATAD2 | 0.837463 | 11 | 0 | 11 |
| BUB1 | CDK1 | 0.834037 | 10 | 0 | 10 |
For details and further investigation, click here
