| Full name: mitochondrial translation release factor 1 | Alias Symbol: RF1|MTTRF1|MGC47721 | ||
| Type: protein-coding gene | Cytoband: 13q14.11 | ||
| Entrez ID: 9617 | HGNC ID: HGNC:7469 | Ensembl Gene: ENSG00000120662 | OMIM ID: 604601 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MTRF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MTRF1 | 9617 | 219822_at | -0.1596 | 0.7646 | |
| GSE20347 | MTRF1 | 9617 | 219822_at | -0.3680 | 0.0105 | |
| GSE23400 | MTRF1 | 9617 | 219822_at | -0.0267 | 0.6392 | |
| GSE26886 | MTRF1 | 9617 | 219822_at | -0.2418 | 0.4360 | |
| GSE29001 | MTRF1 | 9617 | 219822_at | -0.2090 | 0.4927 | |
| GSE38129 | MTRF1 | 9617 | 219822_at | -0.2506 | 0.0414 | |
| GSE45670 | MTRF1 | 9617 | 219822_at | 0.1304 | 0.4950 | |
| GSE53622 | MTRF1 | 9617 | 121272 | -0.0013 | 0.9889 | |
| GSE53624 | MTRF1 | 9617 | 106751 | -0.0747 | 0.4079 | |
| GSE63941 | MTRF1 | 9617 | 219822_at | 0.3317 | 0.5958 | |
| GSE77861 | MTRF1 | 9617 | 219822_at | 0.0213 | 0.9441 | |
| GSE97050 | MTRF1 | 9617 | A_24_P349821 | -0.1366 | 0.5673 | |
| SRP007169 | MTRF1 | 9617 | RNAseq | -0.6542 | 0.1464 | |
| SRP008496 | MTRF1 | 9617 | RNAseq | -0.2064 | 0.5699 | |
| SRP064894 | MTRF1 | 9617 | RNAseq | 0.2039 | 0.3845 | |
| SRP133303 | MTRF1 | 9617 | RNAseq | -0.2650 | 0.0625 | |
| SRP159526 | MTRF1 | 9617 | RNAseq | -0.8787 | 0.0000 | |
| SRP193095 | MTRF1 | 9617 | RNAseq | -0.3401 | 0.0204 | |
| SRP219564 | MTRF1 | 9617 | RNAseq | -0.5887 | 0.0973 | |
| TCGA | MTRF1 | 9617 | RNAseq | -0.2318 | 0.0100 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MTRF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MTRF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MTRF1 | 9617 | 0 | 14 | 16 | |
| GSE20123 | MTRF1 | 9617 | 0 | 13 | 17 | |
| GSE43470 | MTRF1 | 9617 | 3 | 13 | 27 | |
| GSE46452 | MTRF1 | 9617 | 0 | 33 | 26 | |
| GSE47630 | MTRF1 | 9617 | 2 | 27 | 11 | |
| GSE54993 | MTRF1 | 9617 | 12 | 2 | 56 | |
| GSE54994 | MTRF1 | 9617 | 1 | 16 | 36 | |
| GSE60625 | MTRF1 | 9617 | 0 | 3 | 8 | |
| GSE74703 | MTRF1 | 9617 | 3 | 10 | 23 | |
| GSE74704 | MTRF1 | 9617 | 0 | 10 | 10 | |
| TCGA | MTRF1 | 9617 | 7 | 40 | 49 |
Total number of gains: 28; Total number of losses: 181; Total Number of normals: 279.
Somatic mutations of MTRF1:
Generating mutation plots.
Highly correlated genes for MTRF1:
Showing top 20/199 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MTRF1 | USP4 | 0.765155 | 3 | 0 | 3 |
| MTRF1 | SIPA1L2 | 0.75878 | 3 | 0 | 3 |
| MTRF1 | CNOT4 | 0.745939 | 3 | 0 | 3 |
| MTRF1 | SETD4 | 0.743816 | 3 | 0 | 3 |
| MTRF1 | ZNF586 | 0.743423 | 3 | 0 | 3 |
| MTRF1 | CCAR1 | 0.735525 | 3 | 0 | 3 |
| MTRF1 | TANC1 | 0.731175 | 3 | 0 | 3 |
| MTRF1 | KCTD18 | 0.72625 | 3 | 0 | 3 |
| MTRF1 | TMEM181 | 0.718017 | 3 | 0 | 3 |
| MTRF1 | MTIF3 | 0.712178 | 4 | 0 | 3 |
| MTRF1 | IFT74 | 0.711606 | 3 | 0 | 3 |
| MTRF1 | COG3 | 0.708497 | 7 | 0 | 6 |
| MTRF1 | EIF5 | 0.692297 | 3 | 0 | 3 |
| MTRF1 | RUFY3 | 0.688761 | 4 | 0 | 3 |
| MTRF1 | ARL6 | 0.687595 | 3 | 0 | 3 |
| MTRF1 | CIR1 | 0.685434 | 3 | 0 | 3 |
| MTRF1 | TRMT11 | 0.685095 | 3 | 0 | 3 |
| MTRF1 | PURA | 0.681649 | 3 | 0 | 3 |
| MTRF1 | ZNF274 | 0.677964 | 5 | 0 | 4 |
| MTRF1 | MOB4 | 0.67687 | 3 | 0 | 3 |
For details and further investigation, click here
