| Full name: ADP ribosylation factor like GTPase 8B | Alias Symbol: FLJ10702|Gie1 | ||
| Type: protein-coding gene | Cytoband: 3p26.1 | ||
| Entrez ID: 55207 | HGNC ID: HGNC:25564 | Ensembl Gene: ENSG00000134108 | OMIM ID: 616596 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ARL8B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARL8B | 55207 | 217852_s_at | -0.3084 | 0.3622 | |
| GSE20347 | ARL8B | 55207 | 217852_s_at | -0.6955 | 0.0000 | |
| GSE23400 | ARL8B | 55207 | 217852_s_at | -0.2823 | 0.0000 | |
| GSE26886 | ARL8B | 55207 | 217852_s_at | -1.1117 | 0.0000 | |
| GSE29001 | ARL8B | 55207 | 217852_s_at | -0.5448 | 0.0184 | |
| GSE38129 | ARL8B | 55207 | 217852_s_at | -0.4722 | 0.0003 | |
| GSE45670 | ARL8B | 55207 | 217852_s_at | -0.2410 | 0.0070 | |
| GSE53622 | ARL8B | 55207 | 68436 | -0.5891 | 0.0000 | |
| GSE53624 | ARL8B | 55207 | 68436 | -0.6330 | 0.0000 | |
| GSE63941 | ARL8B | 55207 | 217852_s_at | -0.8166 | 0.0249 | |
| GSE77861 | ARL8B | 55207 | 217852_s_at | -0.2167 | 0.3270 | |
| GSE97050 | ARL8B | 55207 | A_23_P385217 | -0.3797 | 0.1454 | |
| SRP007169 | ARL8B | 55207 | RNAseq | -1.5028 | 0.0008 | |
| SRP008496 | ARL8B | 55207 | RNAseq | -1.5490 | 0.0000 | |
| SRP064894 | ARL8B | 55207 | RNAseq | -0.7775 | 0.0000 | |
| SRP133303 | ARL8B | 55207 | RNAseq | -0.2078 | 0.3425 | |
| SRP159526 | ARL8B | 55207 | RNAseq | -1.0019 | 0.0013 | |
| SRP193095 | ARL8B | 55207 | RNAseq | -0.9090 | 0.0000 | |
| SRP219564 | ARL8B | 55207 | RNAseq | -1.1024 | 0.0007 | |
| TCGA | ARL8B | 55207 | RNAseq | 0.0333 | 0.4851 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by ARL8B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARL8B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARL8B | 55207 | 1 | 19 | 10 | |
| GSE20123 | ARL8B | 55207 | 1 | 19 | 10 | |
| GSE43470 | ARL8B | 55207 | 0 | 21 | 22 | |
| GSE46452 | ARL8B | 55207 | 2 | 18 | 39 | |
| GSE47630 | ARL8B | 55207 | 1 | 24 | 15 | |
| GSE54993 | ARL8B | 55207 | 6 | 1 | 63 | |
| GSE54994 | ARL8B | 55207 | 1 | 32 | 20 | |
| GSE60625 | ARL8B | 55207 | 5 | 0 | 6 | |
| GSE74703 | ARL8B | 55207 | 0 | 18 | 18 | |
| GSE74704 | ARL8B | 55207 | 1 | 11 | 8 | |
| TCGA | ARL8B | 55207 | 1 | 68 | 27 |
Total number of gains: 19; Total number of losses: 231; Total Number of normals: 238.
Somatic mutations of ARL8B:
Generating mutation plots.
Highly correlated genes for ARL8B:
Showing top 20/1373 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARL8B | THAP2 | 0.820202 | 3 | 0 | 3 |
| ARL8B | CNOT4 | 0.782764 | 4 | 0 | 4 |
| ARL8B | FAHD1 | 0.76836 | 4 | 0 | 4 |
| ARL8B | CNOT10 | 0.755515 | 3 | 0 | 3 |
| ARL8B | TWF1 | 0.746791 | 11 | 0 | 9 |
| ARL8B | ANXA1 | 0.740758 | 9 | 0 | 9 |
| ARL8B | CA13 | 0.736899 | 3 | 0 | 3 |
| ARL8B | RAB5A | 0.724028 | 13 | 0 | 13 |
| ARL8B | GTF3C6 | 0.722353 | 3 | 0 | 3 |
| ARL8B | EMC3 | 0.721433 | 11 | 0 | 11 |
| ARL8B | SON | 0.715077 | 3 | 0 | 3 |
| ARL8B | MOB3C | 0.71168 | 3 | 0 | 3 |
| ARL8B | IL34 | 0.71072 | 3 | 0 | 3 |
| ARL8B | GANC | 0.709685 | 5 | 0 | 5 |
| ARL8B | CAMK2G | 0.709164 | 3 | 0 | 3 |
| ARL8B | GSKIP | 0.707945 | 6 | 0 | 5 |
| ARL8B | KLF8 | 0.706702 | 11 | 0 | 11 |
| ARL8B | RAB11A | 0.705999 | 11 | 0 | 10 |
| ARL8B | FYTTD1 | 0.702921 | 3 | 0 | 3 |
| ARL8B | DDI2 | 0.701722 | 3 | 0 | 3 |
For details and further investigation, click here
