| Full name: autophagy related 3 | Alias Symbol: PC3-96|FLJ22125|MGC15201|DKFZp564M1178 | ||
| Type: protein-coding gene | Cytoband: 3q13.2 | ||
| Entrez ID: 64422 | HGNC ID: HGNC:20962 | Ensembl Gene: ENSG00000144848 | OMIM ID: 609606 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ATG3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATG3 | 64422 | 221492_s_at | 0.2125 | 0.6179 | |
| GSE20347 | ATG3 | 64422 | 221492_s_at | 0.1954 | 0.2093 | |
| GSE23400 | ATG3 | 64422 | 221492_s_at | 0.5247 | 0.0000 | |
| GSE26886 | ATG3 | 64422 | 221492_s_at | 0.2727 | 0.2510 | |
| GSE29001 | ATG3 | 64422 | 221492_s_at | 0.2088 | 0.7781 | |
| GSE38129 | ATG3 | 64422 | 221492_s_at | 0.2595 | 0.0291 | |
| GSE45670 | ATG3 | 64422 | 221492_s_at | 0.0776 | 0.5792 | |
| GSE53622 | ATG3 | 64422 | 46405 | 0.2333 | 0.0000 | |
| GSE53624 | ATG3 | 64422 | 46405 | 0.2765 | 0.0000 | |
| GSE63941 | ATG3 | 64422 | 221492_s_at | 0.3897 | 0.2585 | |
| GSE77861 | ATG3 | 64422 | 221492_s_at | -0.2853 | 0.4718 | |
| GSE97050 | ATG3 | 64422 | A_23_P212706 | 0.6070 | 0.1379 | |
| SRP007169 | ATG3 | 64422 | RNAseq | -0.6379 | 0.1699 | |
| SRP008496 | ATG3 | 64422 | RNAseq | -0.2855 | 0.3165 | |
| SRP064894 | ATG3 | 64422 | RNAseq | 0.2562 | 0.1904 | |
| SRP133303 | ATG3 | 64422 | RNAseq | 0.2094 | 0.2298 | |
| SRP159526 | ATG3 | 64422 | RNAseq | -0.0240 | 0.9273 | |
| SRP193095 | ATG3 | 64422 | RNAseq | -0.0772 | 0.4902 | |
| SRP219564 | ATG3 | 64422 | RNAseq | 0.1091 | 0.6558 | |
| TCGA | ATG3 | 64422 | RNAseq | 0.0408 | 0.4030 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ATG3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATG3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATG3 | 64422 | 17 | 1 | 12 | |
| GSE20123 | ATG3 | 64422 | 17 | 1 | 12 | |
| GSE43470 | ATG3 | 64422 | 20 | 1 | 22 | |
| GSE46452 | ATG3 | 64422 | 12 | 6 | 41 | |
| GSE47630 | ATG3 | 64422 | 16 | 6 | 18 | |
| GSE54993 | ATG3 | 64422 | 2 | 5 | 63 | |
| GSE54994 | ATG3 | 64422 | 29 | 4 | 20 | |
| GSE60625 | ATG3 | 64422 | 0 | 6 | 5 | |
| GSE74703 | ATG3 | 64422 | 16 | 1 | 19 | |
| GSE74704 | ATG3 | 64422 | 13 | 1 | 6 | |
| TCGA | ATG3 | 64422 | 52 | 7 | 37 |
Total number of gains: 194; Total number of losses: 39; Total Number of normals: 255.
Somatic mutations of ATG3:
Generating mutation plots.
Highly correlated genes for ATG3:
Showing top 20/764 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATG3 | UBE2L3 | 0.789117 | 3 | 0 | 3 |
| ATG3 | RAP1GDS1 | 0.784263 | 3 | 0 | 3 |
| ATG3 | PPP2R5E | 0.782661 | 3 | 0 | 3 |
| ATG3 | CALML5 | 0.782519 | 3 | 0 | 3 |
| ATG3 | PITRM1 | 0.776827 | 3 | 0 | 3 |
| ATG3 | RCHY1 | 0.771072 | 3 | 0 | 3 |
| ATG3 | NAA50 | 0.763678 | 11 | 0 | 10 |
| ATG3 | FAM200A | 0.754723 | 3 | 0 | 3 |
| ATG3 | MED26 | 0.753552 | 3 | 0 | 3 |
| ATG3 | SNUPN | 0.740728 | 4 | 0 | 4 |
| ATG3 | ANXA7 | 0.735831 | 3 | 0 | 3 |
| ATG3 | FBXW8 | 0.735528 | 3 | 0 | 3 |
| ATG3 | VPS25 | 0.726992 | 3 | 0 | 3 |
| ATG3 | VTI1B | 0.723509 | 3 | 0 | 3 |
| ATG3 | ALKBH7 | 0.714139 | 3 | 0 | 3 |
| ATG3 | BTAF1 | 0.710328 | 3 | 0 | 3 |
| ATG3 | RPL41 | 0.710061 | 4 | 0 | 4 |
| ATG3 | GET4 | 0.705596 | 3 | 0 | 3 |
| ATG3 | ELAC2 | 0.702626 | 4 | 0 | 3 |
| ATG3 | PPP1R2 | 0.700825 | 4 | 0 | 3 |
For details and further investigation, click here
