| Full name: transmembrane protein 116 | Alias Symbol: FLJ90167 | ||
| Type: protein-coding gene | Cytoband: 12q24.13 | ||
| Entrez ID: 89894 | HGNC ID: HGNC:25084 | Ensembl Gene: ENSG00000198270 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of TMEM116:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMEM116 | 89894 | 227172_at | 0.0484 | 0.9751 | |
| GSE26886 | TMEM116 | 89894 | 227172_at | 0.7833 | 0.1627 | |
| GSE45670 | TMEM116 | 89894 | 227172_at | 0.3789 | 0.4806 | |
| GSE53622 | TMEM116 | 89894 | 24090 | 0.5936 | 0.0003 | |
| GSE53624 | TMEM116 | 89894 | 24090 | 0.7007 | 0.0000 | |
| GSE63941 | TMEM116 | 89894 | 227172_at | 0.4174 | 0.5689 | |
| GSE77861 | TMEM116 | 89894 | 234133_s_at | -0.0792 | 0.5672 | |
| GSE97050 | TMEM116 | 89894 | A_23_P105619 | -0.1246 | 0.7316 | |
| SRP007169 | TMEM116 | 89894 | RNAseq | 0.6925 | 0.2643 | |
| SRP008496 | TMEM116 | 89894 | RNAseq | 1.1454 | 0.0286 | |
| SRP064894 | TMEM116 | 89894 | RNAseq | 0.0758 | 0.7489 | |
| SRP133303 | TMEM116 | 89894 | RNAseq | -0.1446 | 0.5191 | |
| SRP159526 | TMEM116 | 89894 | RNAseq | 1.7835 | 0.0007 | |
| SRP193095 | TMEM116 | 89894 | RNAseq | 1.0944 | 0.0012 | |
| SRP219564 | TMEM116 | 89894 | RNAseq | 0.1891 | 0.7090 | |
| TCGA | TMEM116 | 89894 | RNAseq | -0.0036 | 0.9833 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by TMEM116 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMEM116:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMEM116 | 89894 | 5 | 3 | 22 | |
| GSE20123 | TMEM116 | 89894 | 5 | 3 | 22 | |
| GSE43470 | TMEM116 | 89894 | 2 | 1 | 40 | |
| GSE46452 | TMEM116 | 89894 | 9 | 1 | 49 | |
| GSE47630 | TMEM116 | 89894 | 9 | 3 | 28 | |
| GSE54993 | TMEM116 | 89894 | 0 | 5 | 65 | |
| GSE54994 | TMEM116 | 89894 | 4 | 2 | 47 | |
| GSE60625 | TMEM116 | 89894 | 0 | 0 | 11 | |
| GSE74703 | TMEM116 | 89894 | 2 | 0 | 34 | |
| GSE74704 | TMEM116 | 89894 | 2 | 2 | 16 | |
| TCGA | TMEM116 | 89894 | 22 | 11 | 63 |
Total number of gains: 60; Total number of losses: 31; Total Number of normals: 397.
Somatic mutations of TMEM116:
Generating mutation plots.
Highly correlated genes for TMEM116:
Showing top 20/78 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMEM116 | JAKMIP3 | 0.784379 | 3 | 0 | 3 |
| TMEM116 | NMUR1 | 0.741067 | 3 | 0 | 3 |
| TMEM116 | SOX2-OT | 0.711601 | 5 | 0 | 5 |
| TMEM116 | TXNRD1 | 0.697806 | 6 | 0 | 6 |
| TMEM116 | ADAM23 | 0.694289 | 6 | 0 | 6 |
| TMEM116 | TUBB2B | 0.671305 | 3 | 0 | 3 |
| TMEM116 | SRXN1 | 0.659535 | 4 | 0 | 4 |
| TMEM116 | CABYR | 0.657074 | 6 | 0 | 6 |
| TMEM116 | CLDN20 | 0.650709 | 6 | 0 | 4 |
| TMEM116 | TREML2 | 0.637789 | 3 | 0 | 3 |
| TMEM116 | CYP26A1 | 0.636652 | 7 | 0 | 7 |
| TMEM116 | SSPO | 0.635896 | 3 | 0 | 3 |
| TMEM116 | STRBP | 0.633124 | 3 | 0 | 3 |
| TMEM116 | OSGIN1 | 0.628318 | 5 | 0 | 4 |
| TMEM116 | SCN9A | 0.623615 | 6 | 0 | 4 |
| TMEM116 | ABCC5 | 0.610899 | 7 | 0 | 6 |
| TMEM116 | MAP2K6 | 0.610186 | 3 | 0 | 3 |
| TMEM116 | MGAT3 | 0.608784 | 3 | 0 | 3 |
| TMEM116 | OST4 | 0.607835 | 3 | 0 | 3 |
| TMEM116 | PIR | 0.607624 | 8 | 0 | 6 |
For details and further investigation, click here
