STAG2

 

Full name: stromal antigen 2 Alias Symbol: SA-2|SCC3B|SA2
Type: protein-coding gene Cytoband: Xq25
Entrez ID: 10735 HGNC ID: HGNC:11355 Ensembl Gene: ENSG00000101972 OMIM ID: 300826
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 45/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

STAG2 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle

 

Expression of STAG2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 STAG2 10735 209022_at -0.0526 0.8977
GSE20347 STAG2 10735 209022_at 0.3950 0.0078
GSE23400 STAG2 10735 209022_at 0.5945 0.0000
GSE26886 STAG2 10735 209022_at 0.6601 0.0002
GSE29001 STAG2 10735 209023_s_at 0.1238 0.6635
GSE38129 STAG2 10735 209022_at 0.3483 0.0017
GSE45670 STAG2 10735 209022_at -0.0108 0.9656
GSE53622 STAG2 10735 92295 0.3909 0.0000
GSE53624 STAG2 10735 92295 0.3161 0.0000
GSE63941 STAG2 10735 209022_at 0.3929 0.3506
GSE77861 STAG2 10735 209022_at 0.4308 0.0235
GSE97050 STAG2 10735 A_33_P3304293 0.2305 0.3317
SRP007169 STAG2 10735 RNAseq 0.9323 0.0528
SRP008496 STAG2 10735 RNAseq 1.2816 0.0000
SRP064894 STAG2 10735 RNAseq 0.0119 0.9580
SRP133303 STAG2 10735 RNAseq 0.5559 0.0035
SRP159526 STAG2 10735 RNAseq 0.1068 0.5901
SRP193095 STAG2 10735 RNAseq 0.1485 0.2610
SRP219564 STAG2 10735 RNAseq -0.0649 0.8467
TCGA STAG2 10735 RNAseq 0.1032 0.0164

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by STAG2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of STAG2:

 

No record found for this gene.

 

Somatic mutations of STAG2:

 

Generating mutation plots.

 

Highly correlated genes for STAG2:

 

Showing top 20/967 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
STAG2CTSF0.750293303
STAG2TMTC10.748453404
STAG2CHIC10.745875303
STAG2TGFBR10.730736303
STAG2LARP70.717554403
STAG2PPP2R5C0.708776303
STAG2TMEM167B0.706125303
STAG2FHOD30.704523303
STAG2CDC42SE20.703964504
STAG2PPP1R80.702675303
STAG2ATF60.702317404
STAG2LIX1L0.702133303
STAG2ABL10.698256303
STAG2SAAL10.695604404
STAG2TAOK10.695228403
STAG2BCAS30.690061303
STAG2ROCK10.690026404
STAG2SMARCE10.688544403
STAG2EZH20.684404403
STAG2ATP11C0.683689706

For details and further investigation, click here