| Full name: C-type lectin domain containing 7A | Alias Symbol: dectin-1|hDectin-1|CD369|SCARE2 | ||
| Type: protein-coding gene | Cytoband: 12p13.2 | ||
| Entrez ID: 64581 | HGNC ID: HGNC:14558 | Ensembl Gene: ENSG00000172243 | OMIM ID: 606264 |
| Drug and gene relationship at DGIdb | |||
CLEC7A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05152 | Tuberculosis |
Expression of CLEC7A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLEC7A | 64581 | 221698_s_at | 1.3625 | 0.3403 | |
| GSE20347 | CLEC7A | 64581 | 221698_s_at | -0.0476 | 0.9182 | |
| GSE23400 | CLEC7A | 64581 | 221698_s_at | 0.6590 | 0.0000 | |
| GSE26886 | CLEC7A | 64581 | 221698_s_at | 0.2670 | 0.6360 | |
| GSE29001 | CLEC7A | 64581 | 221698_s_at | 1.0065 | 0.1062 | |
| GSE38129 | CLEC7A | 64581 | 221698_s_at | 0.4225 | 0.1978 | |
| GSE45670 | CLEC7A | 64581 | 221698_s_at | 1.2582 | 0.0017 | |
| GSE53622 | CLEC7A | 64581 | 101023 | 0.8937 | 0.0000 | |
| GSE53624 | CLEC7A | 64581 | 31040 | 0.5539 | 0.0003 | |
| GSE63941 | CLEC7A | 64581 | 1554406_a_at | 1.0603 | 0.2916 | |
| GSE77861 | CLEC7A | 64581 | 221698_s_at | -0.1853 | 0.6690 | |
| GSE97050 | CLEC7A | 64581 | A_24_P227415 | 0.4217 | 0.1782 | |
| SRP007169 | CLEC7A | 64581 | RNAseq | -0.1466 | 0.8370 | |
| SRP008496 | CLEC7A | 64581 | RNAseq | -0.3313 | 0.5336 | |
| SRP064894 | CLEC7A | 64581 | RNAseq | 0.9572 | 0.0036 | |
| SRP133303 | CLEC7A | 64581 | RNAseq | 0.7082 | 0.0086 | |
| SRP159526 | CLEC7A | 64581 | RNAseq | -0.2650 | 0.6548 | |
| SRP193095 | CLEC7A | 64581 | RNAseq | 0.6220 | 0.0198 | |
| SRP219564 | CLEC7A | 64581 | RNAseq | 1.1127 | 0.0298 | |
| TCGA | CLEC7A | 64581 | RNAseq | 1.1462 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by CLEC7A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLEC7A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLEC7A | 64581 | 6 | 2 | 22 | |
| GSE20123 | CLEC7A | 64581 | 6 | 2 | 22 | |
| GSE43470 | CLEC7A | 64581 | 8 | 3 | 32 | |
| GSE46452 | CLEC7A | 64581 | 10 | 1 | 48 | |
| GSE47630 | CLEC7A | 64581 | 14 | 2 | 24 | |
| GSE54993 | CLEC7A | 64581 | 1 | 10 | 59 | |
| GSE54994 | CLEC7A | 64581 | 9 | 2 | 42 | |
| GSE60625 | CLEC7A | 64581 | 0 | 1 | 10 | |
| GSE74703 | CLEC7A | 64581 | 8 | 2 | 26 | |
| GSE74704 | CLEC7A | 64581 | 4 | 1 | 15 | |
| TCGA | CLEC7A | 64581 | 39 | 6 | 51 |
Total number of gains: 105; Total number of losses: 32; Total Number of normals: 351.
Somatic mutations of CLEC7A:
Generating mutation plots.
Highly correlated genes for CLEC7A:
Showing top 20/376 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLEC7A | CISD2 | 0.712174 | 3 | 0 | 3 |
| CLEC7A | SEL1L3 | 0.694452 | 3 | 0 | 3 |
| CLEC7A | QSER1 | 0.682761 | 4 | 0 | 4 |
| CLEC7A | FCGR3A | 0.678986 | 3 | 0 | 3 |
| CLEC7A | GPR141 | 0.678644 | 3 | 0 | 3 |
| CLEC7A | BIRC3 | 0.673758 | 4 | 0 | 3 |
| CLEC7A | ERCC8 | 0.669306 | 4 | 0 | 4 |
| CLEC7A | HDAC3 | 0.66604 | 3 | 0 | 3 |
| CLEC7A | FCER1G | 0.665486 | 5 | 0 | 4 |
| CLEC7A | SLC36A1 | 0.664545 | 3 | 0 | 3 |
| CLEC7A | CCR8 | 0.662118 | 5 | 0 | 5 |
| CLEC7A | PDCD1LG2 | 0.656664 | 3 | 0 | 3 |
| CLEC7A | FAT1 | 0.656351 | 3 | 0 | 3 |
| CLEC7A | DPF2 | 0.654421 | 3 | 0 | 3 |
| CLEC7A | COL5A3 | 0.654149 | 3 | 0 | 3 |
| CLEC7A | FTO | 0.653339 | 3 | 0 | 3 |
| CLEC7A | LY96 | 0.650192 | 6 | 0 | 4 |
| CLEC7A | APOBR | 0.647737 | 4 | 0 | 3 |
| CLEC7A | CD93 | 0.643808 | 3 | 0 | 3 |
| CLEC7A | IGSF6 | 0.639723 | 6 | 0 | 5 |
For details and further investigation, click here
