BIRC3

 

Full name: baculoviral IAP repeat containing 3 Alias Symbol: cIAP2|hiap-1|MIHC|RNF49|MALT2|c-IAP2
Type: protein-coding gene Cytoband: 11q22.2
Entrez ID: 330 HGNC ID: HGNC:591 Ensembl Gene: ENSG00000023445 OMIM ID: 601721
Drug and gene relationship at DGIdb

 

BIRC3 involved pathways:

KEGG pathway Description View
hsa04064NF-kappa B signaling pathway
hsa04210Apoptosis
hsa04510Focal adhesion
hsa04621NOD-like receptor signaling pathway
hsa04668TNF signaling pathway
hsa05145Toxoplasmosis
hsa05200Pathways in cancer
hsa05222Small cell lung cancer

 

Expression of BIRC3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BIRC3 330 210538_s_at 0.7687 0.3931
GSE20347 BIRC3 330 210538_s_at 0.9540 0.0474
GSE23400 BIRC3 330 210538_s_at 0.0732 0.6938
GSE26886 BIRC3 330 210538_s_at 0.9835 0.1873
GSE29001 BIRC3 330 210538_s_at 0.2303 0.5642
GSE38129 BIRC3 330 210538_s_at 0.3204 0.4404
GSE45670 BIRC3 330 210538_s_at 0.1987 0.6558
GSE53622 BIRC3 330 34883 0.0750 0.7064
GSE53624 BIRC3 330 34883 -0.0898 0.5840
GSE63941 BIRC3 330 210538_s_at 1.8021 0.2818
GSE77861 BIRC3 330 210538_s_at 0.3396 0.3734
GSE97050 BIRC3 330 A_23_P98350 0.5399 0.2109
SRP007169 BIRC3 330 RNAseq 2.2125 0.0215
SRP008496 BIRC3 330 RNAseq 0.8348 0.3127
SRP064894 BIRC3 330 RNAseq -0.1502 0.6232
SRP133303 BIRC3 330 RNAseq 0.4066 0.2741
SRP159526 BIRC3 330 RNAseq -0.0089 0.9887
SRP193095 BIRC3 330 RNAseq 0.2867 0.4564
SRP219564 BIRC3 330 RNAseq 2.6482 0.0004
TCGA BIRC3 330 RNAseq -0.4919 0.0026

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by BIRC3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BIRC3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BIRC3 330 5 8 17
GSE20123 BIRC3 330 5 8 17
GSE43470 BIRC3 330 6 5 32
GSE46452 BIRC3 330 5 24 30
GSE47630 BIRC3 330 2 19 19
GSE54993 BIRC3 330 9 1 60
GSE54994 BIRC3 330 6 18 29
GSE60625 BIRC3 330 0 3 8
GSE74703 BIRC3 330 4 4 28
GSE74704 BIRC3 330 5 4 11
TCGA BIRC3 330 11 44 41

Total number of gains: 58; Total number of losses: 138; Total Number of normals: 292.  

 

Somatic mutations of BIRC3:

 

Generating mutation plots.

 

Highly correlated genes for BIRC3:

 

Showing top 20/297 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BIRC3DCLRE1C0.848946303
BIRC3NUS10.824619303
BIRC3C8orf370.818526303
BIRC3C2orf690.80269303
BIRC3NEK60.79888303
BIRC3PDIA60.745749303
BIRC3C8orf440.742908303
BIRC3C17orf750.742624303
BIRC3CCDC1270.741123303
BIRC3FAM49A0.726525403
BIRC3UTP60.726483303
BIRC3PDE7A0.722059303
BIRC3FTSJ30.721949303
BIRC3CCL220.719962303
BIRC3STEAP40.713684303
BIRC3STK17A0.707767303
BIRC3NDUFA90.705925303
BIRC3MBD40.702635403
BIRC3ATP13A30.697318303
BIRC3TNFSF150.688294504

For details and further investigation, click here