| Full name: C-C motif chemokine receptor 8 | Alias Symbol: CY6|TER1|CKR-L1|GPR-CY6|CDw198 | ||
| Type: protein-coding gene | Cytoband: 3p22.1 | ||
| Entrez ID: 1237 | HGNC ID: HGNC:1609 | Ensembl Gene: ENSG00000179934 | OMIM ID: 601834 |
| Drug and gene relationship at DGIdb | |||
CCR8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of CCR8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCR8 | 1237 | 208059_at | 0.2826 | 0.2362 | |
| GSE20347 | CCR8 | 1237 | 208059_at | 0.2227 | 0.0383 | |
| GSE23400 | CCR8 | 1237 | 208059_at | 0.1041 | 0.0230 | |
| GSE26886 | CCR8 | 1237 | 208059_at | -0.1624 | 0.2074 | |
| GSE29001 | CCR8 | 1237 | 208059_at | 0.1467 | 0.4135 | |
| GSE38129 | CCR8 | 1237 | 208059_at | 0.1842 | 0.0167 | |
| GSE45670 | CCR8 | 1237 | 208059_at | 0.3137 | 0.0050 | |
| GSE53622 | CCR8 | 1237 | 117171 | 1.5543 | 0.0000 | |
| GSE53624 | CCR8 | 1237 | 117171 | 1.4028 | 0.0000 | |
| GSE63941 | CCR8 | 1237 | 208059_at | -0.2681 | 0.1160 | |
| GSE77861 | CCR8 | 1237 | 208059_at | 0.0359 | 0.7159 | |
| GSE97050 | CCR8 | 1237 | A_23_P69012 | 0.3249 | 0.2660 | |
| TCGA | CCR8 | 1237 | RNAseq | 3.2159 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by CCR8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCR8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCR8 | 1237 | 0 | 19 | 11 | |
| GSE20123 | CCR8 | 1237 | 0 | 19 | 11 | |
| GSE43470 | CCR8 | 1237 | 0 | 20 | 23 | |
| GSE46452 | CCR8 | 1237 | 2 | 17 | 40 | |
| GSE47630 | CCR8 | 1237 | 1 | 25 | 14 | |
| GSE54993 | CCR8 | 1237 | 7 | 2 | 61 | |
| GSE54994 | CCR8 | 1237 | 0 | 34 | 19 | |
| GSE60625 | CCR8 | 1237 | 5 | 0 | 6 | |
| GSE74703 | CCR8 | 1237 | 0 | 16 | 20 | |
| GSE74704 | CCR8 | 1237 | 0 | 13 | 7 | |
| TCGA | CCR8 | 1237 | 1 | 71 | 24 |
Total number of gains: 16; Total number of losses: 236; Total Number of normals: 236.
Somatic mutations of CCR8:
Generating mutation plots.
Highly correlated genes for CCR8:
Showing top 20/651 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCR8 | DPPA4 | 0.745822 | 3 | 0 | 3 |
| CCR8 | KCNA1 | 0.740309 | 3 | 0 | 3 |
| CCR8 | TIGIT | 0.710373 | 5 | 0 | 4 |
| CCR8 | EML4 | 0.690146 | 3 | 0 | 3 |
| CCR8 | LRRC25 | 0.690073 | 3 | 0 | 3 |
| CCR8 | PLXNC1 | 0.67631 | 4 | 0 | 3 |
| CCR8 | SYT12 | 0.66726 | 5 | 0 | 4 |
| CCR8 | SIGLEC12 | 0.663432 | 3 | 0 | 3 |
| CCR8 | NEUROD2 | 0.663059 | 4 | 0 | 3 |
| CCR8 | EPSTI1 | 0.662257 | 5 | 0 | 5 |
| CCR8 | CLEC7A | 0.662118 | 5 | 0 | 5 |
| CCR8 | POU5F1B | 0.658615 | 4 | 0 | 3 |
| CCR8 | GPR84 | 0.654739 | 4 | 0 | 3 |
| CCR8 | LRRC8C | 0.65458 | 3 | 0 | 3 |
| CCR8 | APOC1 | 0.650169 | 7 | 0 | 6 |
| CCR8 | CLDN16 | 0.648368 | 6 | 0 | 5 |
| CCR8 | IL4I1 | 0.64794 | 5 | 0 | 4 |
| CCR8 | RNASE3 | 0.647932 | 7 | 0 | 6 |
| CCR8 | SNX20 | 0.644723 | 4 | 0 | 4 |
| CCR8 | CHST11 | 0.644663 | 5 | 0 | 5 |
For details and further investigation, click here
