| Full name: CDC like kinase 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q35.3 | ||
| Entrez ID: 57396 | HGNC ID: HGNC:13659 | Ensembl Gene: ENSG00000113240 | OMIM ID: 607969 |
| Drug and gene relationship at DGIdb | |||
Expression of CLK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLK4 | 57396 | 210346_s_at | -0.1954 | 0.7796 | |
| GSE20347 | CLK4 | 57396 | 210346_s_at | -0.1903 | 0.2862 | |
| GSE23400 | CLK4 | 57396 | 210346_s_at | -0.0137 | 0.9012 | |
| GSE26886 | CLK4 | 57396 | 210346_s_at | -0.2636 | 0.3582 | |
| GSE29001 | CLK4 | 57396 | 210346_s_at | -0.2233 | 0.4048 | |
| GSE38129 | CLK4 | 57396 | 210346_s_at | -0.2198 | 0.2649 | |
| GSE45670 | CLK4 | 57396 | 210346_s_at | -0.2500 | 0.1837 | |
| GSE53622 | CLK4 | 57396 | 38281 | -0.3120 | 0.0005 | |
| GSE53624 | CLK4 | 57396 | 45384 | -0.5862 | 0.0000 | |
| GSE63941 | CLK4 | 57396 | 210346_s_at | -0.0826 | 0.8652 | |
| GSE77861 | CLK4 | 57396 | 210346_s_at | -0.5636 | 0.0109 | |
| GSE97050 | CLK4 | 57396 | A_23_P61674 | -0.2591 | 0.2501 | |
| SRP007169 | CLK4 | 57396 | RNAseq | -0.5370 | 0.2842 | |
| SRP064894 | CLK4 | 57396 | RNAseq | -0.3293 | 0.0961 | |
| SRP133303 | CLK4 | 57396 | RNAseq | -0.3269 | 0.0270 | |
| SRP159526 | CLK4 | 57396 | RNAseq | -0.7196 | 0.0027 | |
| SRP193095 | CLK4 | 57396 | RNAseq | -0.4441 | 0.0014 | |
| SRP219564 | CLK4 | 57396 | RNAseq | -0.0911 | 0.8032 | |
| TCGA | CLK4 | 57396 | RNAseq | -0.3276 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CLK4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLK4 | 57396 | 2 | 13 | 15 | |
| GSE20123 | CLK4 | 57396 | 2 | 13 | 15 | |
| GSE43470 | CLK4 | 57396 | 1 | 11 | 31 | |
| GSE46452 | CLK4 | 57396 | 0 | 27 | 32 | |
| GSE47630 | CLK4 | 57396 | 1 | 20 | 19 | |
| GSE54993 | CLK4 | 57396 | 10 | 2 | 58 | |
| GSE54994 | CLK4 | 57396 | 2 | 17 | 34 | |
| GSE60625 | CLK4 | 57396 | 1 | 0 | 10 | |
| GSE74703 | CLK4 | 57396 | 1 | 7 | 28 | |
| GSE74704 | CLK4 | 57396 | 1 | 6 | 13 | |
| TCGA | CLK4 | 57396 | 9 | 34 | 53 |
Total number of gains: 30; Total number of losses: 150; Total Number of normals: 308.
Somatic mutations of CLK4:
Generating mutation plots.
Highly correlated genes for CLK4:
Showing top 20/319 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLK4 | PARD3 | 0.739315 | 3 | 0 | 3 |
| CLK4 | CAPZB | 0.727497 | 3 | 0 | 3 |
| CLK4 | SLC35E2B | 0.723359 | 3 | 0 | 3 |
| CLK4 | ZNF445 | 0.714951 | 3 | 0 | 3 |
| CLK4 | MDFIC | 0.708614 | 3 | 0 | 3 |
| CLK4 | ZNF394 | 0.707277 | 3 | 0 | 3 |
| CLK4 | TRIM6 | 0.706026 | 3 | 0 | 3 |
| CLK4 | NBPF1 | 0.70421 | 3 | 0 | 3 |
| CLK4 | CD59 | 0.702968 | 3 | 0 | 3 |
| CLK4 | TRIM3 | 0.701866 | 3 | 0 | 3 |
| CLK4 | CNST | 0.697843 | 4 | 0 | 3 |
| CLK4 | PPM1L | 0.697467 | 3 | 0 | 3 |
| CLK4 | SPIC | 0.697214 | 3 | 0 | 3 |
| CLK4 | RBM5 | 0.688838 | 7 | 0 | 6 |
| CLK4 | BRWD3 | 0.680848 | 3 | 0 | 3 |
| CLK4 | MAN2B2 | 0.680811 | 4 | 0 | 4 |
| CLK4 | NDUFB3 | 0.676136 | 3 | 0 | 3 |
| CLK4 | ARID2 | 0.674816 | 3 | 0 | 3 |
| CLK4 | TPCN1 | 0.671696 | 4 | 0 | 3 |
| CLK4 | CGNL1 | 0.671282 | 4 | 0 | 4 |
For details and further investigation, click here
