| Full name: tripartite motif containing 6 | Alias Symbol: RNF89 | ||
| Type: protein-coding gene | Cytoband: 11p15.4 | ||
| Entrez ID: 117854 | HGNC ID: HGNC:16277 | Ensembl Gene: ENSG00000121236 | OMIM ID: 607564 |
| Drug and gene relationship at DGIdb | |||
Expression of TRIM6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRIM6 | 117854 | 223599_at | -1.2039 | 0.2152 | |
| GSE26886 | TRIM6 | 117854 | 223599_at | -1.8024 | 0.0000 | |
| GSE45670 | TRIM6 | 117854 | 223599_at | -0.0743 | 0.8976 | |
| GSE53622 | TRIM6 | 117854 | 30843 | -1.2487 | 0.0000 | |
| GSE53624 | TRIM6 | 117854 | 30843 | -1.3864 | 0.0000 | |
| GSE63941 | TRIM6 | 117854 | 223599_at | -1.1009 | 0.4427 | |
| GSE77861 | TRIM6 | 117854 | 223599_at | -1.6145 | 0.0013 | |
| GSE97050 | TRIM6 | 117854 | A_33_P3220247 | -0.4382 | 0.2358 | |
| SRP007169 | TRIM6 | 117854 | RNAseq | -1.4792 | 0.0194 | |
| SRP064894 | TRIM6 | 117854 | RNAseq | -0.5672 | 0.0758 | |
| SRP133303 | TRIM6 | 117854 | RNAseq | -0.7563 | 0.0036 | |
| SRP159526 | TRIM6 | 117854 | RNAseq | -2.3418 | 0.0001 | |
| SRP193095 | TRIM6 | 117854 | RNAseq | -0.7500 | 0.0038 | |
| SRP219564 | TRIM6 | 117854 | RNAseq | -0.5831 | 0.1697 | |
| TCGA | TRIM6 | 117854 | RNAseq | 0.3570 | 0.0744 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by TRIM6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRIM6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRIM6 | 117854 | 1 | 11 | 18 | |
| GSE20123 | TRIM6 | 117854 | 1 | 11 | 18 | |
| GSE43470 | TRIM6 | 117854 | 1 | 8 | 34 | |
| GSE46452 | TRIM6 | 117854 | 7 | 8 | 44 | |
| GSE47630 | TRIM6 | 117854 | 3 | 13 | 24 | |
| GSE54993 | TRIM6 | 117854 | 3 | 1 | 66 | |
| GSE54994 | TRIM6 | 117854 | 2 | 12 | 39 | |
| GSE60625 | TRIM6 | 117854 | 0 | 0 | 11 | |
| GSE74703 | TRIM6 | 117854 | 1 | 6 | 29 | |
| GSE74704 | TRIM6 | 117854 | 0 | 8 | 12 | |
| TCGA | TRIM6 | 117854 | 7 | 39 | 50 |
Total number of gains: 26; Total number of losses: 117; Total Number of normals: 345.
Somatic mutations of TRIM6:
Generating mutation plots.
Highly correlated genes for TRIM6:
Showing top 20/1454 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRIM6 | RBM20 | 0.812834 | 3 | 0 | 3 |
| TRIM6 | ZNF175 | 0.81081 | 3 | 0 | 3 |
| TRIM6 | HDHD2 | 0.79962 | 4 | 0 | 4 |
| TRIM6 | PDCD7 | 0.793466 | 3 | 0 | 3 |
| TRIM6 | PDLIM2 | 0.791853 | 4 | 0 | 4 |
| TRIM6 | KIAA0355 | 0.780431 | 3 | 0 | 3 |
| TRIM6 | IMPACT | 0.77859 | 3 | 0 | 3 |
| TRIM6 | SPAG17 | 0.778175 | 4 | 0 | 4 |
| TRIM6 | COPZ1 | 0.77599 | 3 | 0 | 3 |
| TRIM6 | HMGN1 | 0.760566 | 3 | 0 | 3 |
| TRIM6 | CRBN | 0.758029 | 3 | 0 | 3 |
| TRIM6 | ANKRD22 | 0.754883 | 3 | 0 | 3 |
| TRIM6 | EEA1 | 0.753402 | 7 | 0 | 7 |
| TRIM6 | EPB41L4A | 0.752749 | 4 | 0 | 4 |
| TRIM6 | KLF3 | 0.750939 | 6 | 0 | 6 |
| TRIM6 | PDIK1L | 0.748666 | 3 | 0 | 3 |
| TRIM6 | RAD23B | 0.741717 | 3 | 0 | 3 |
| TRIM6 | APC | 0.741475 | 3 | 0 | 3 |
| TRIM6 | FAM83D | 0.740813 | 4 | 0 | 4 |
| TRIM6 | CCDC25 | 0.73655 | 3 | 0 | 3 |
For details and further investigation, click here
