| Full name: transgelin | Alias Symbol: SM22|WS3-10|TAGLN1|SMCC|DKFZp686P11128 | ||
| Type: protein-coding gene | Cytoband: 11q23.2 | ||
| Entrez ID: 6876 | HGNC ID: HGNC:11553 | Ensembl Gene: ENSG00000149591 | OMIM ID: 600818 |
| Drug and gene relationship at DGIdb | |||
Expression of TAGLN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TAGLN | 6876 | 205547_s_at | -1.2712 | 0.4342 | |
| GSE20347 | TAGLN | 6876 | 205547_s_at | -0.2105 | 0.7513 | |
| GSE23400 | TAGLN | 6876 | 205547_s_at | -0.6362 | 0.0169 | |
| GSE26886 | TAGLN | 6876 | 226523_at | 0.1760 | 0.3171 | |
| GSE29001 | TAGLN | 6876 | 205547_s_at | -0.4413 | 0.6561 | |
| GSE38129 | TAGLN | 6876 | 205547_s_at | -0.4994 | 0.4537 | |
| GSE45670 | TAGLN | 6876 | 1555724_s_at | -3.3370 | 0.0000 | |
| GSE53622 | TAGLN | 6876 | 101110 | -1.4560 | 0.0000 | |
| GSE53624 | TAGLN | 6876 | 101110 | -1.0993 | 0.0000 | |
| GSE63941 | TAGLN | 6876 | 226523_at | -0.2330 | 0.4154 | |
| GSE77861 | TAGLN | 6876 | 226523_at | -0.0554 | 0.7014 | |
| GSE97050 | TAGLN | 6876 | A_23_P87013 | -1.2390 | 0.1296 | |
| SRP007169 | TAGLN | 6876 | RNAseq | 3.9209 | 0.0000 | |
| SRP008496 | TAGLN | 6876 | RNAseq | 4.7207 | 0.0000 | |
| SRP064894 | TAGLN | 6876 | RNAseq | -0.6357 | 0.0994 | |
| SRP133303 | TAGLN | 6876 | RNAseq | -1.4010 | 0.0003 | |
| SRP159526 | TAGLN | 6876 | RNAseq | -0.8899 | 0.1932 | |
| SRP193095 | TAGLN | 6876 | RNAseq | 0.5930 | 0.2575 | |
| SRP219564 | TAGLN | 6876 | RNAseq | -1.1964 | 0.3195 | |
| TCGA | TAGLN | 6876 | RNAseq | -0.4207 | 0.0006 |
Upregulated datasets: 2; Downregulated datasets: 4.
Survival by TAGLN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TAGLN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TAGLN | 6876 | 1 | 13 | 16 | |
| GSE20123 | TAGLN | 6876 | 1 | 13 | 16 | |
| GSE43470 | TAGLN | 6876 | 2 | 8 | 33 | |
| GSE46452 | TAGLN | 6876 | 3 | 26 | 30 | |
| GSE47630 | TAGLN | 6876 | 2 | 19 | 19 | |
| GSE54993 | TAGLN | 6876 | 10 | 0 | 60 | |
| GSE54994 | TAGLN | 6876 | 5 | 19 | 29 | |
| GSE60625 | TAGLN | 6876 | 0 | 3 | 8 | |
| GSE74703 | TAGLN | 6876 | 1 | 5 | 30 | |
| GSE74704 | TAGLN | 6876 | 0 | 9 | 11 | |
| TCGA | TAGLN | 6876 | 5 | 50 | 41 |
Total number of gains: 30; Total number of losses: 165; Total Number of normals: 293.
Somatic mutations of TAGLN:
Generating mutation plots.
Highly correlated genes for TAGLN:
Showing top 20/984 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TAGLN | ACTA2 | 0.900223 | 12 | 0 | 12 |
| TAGLN | ACTG2 | 0.868895 | 12 | 0 | 12 |
| TAGLN | CNN1 | 0.855318 | 10 | 0 | 10 |
| TAGLN | ACTBL2 | 0.852587 | 3 | 0 | 3 |
| TAGLN | TPM2 | 0.847629 | 12 | 0 | 12 |
| TAGLN | MYL9 | 0.83933 | 13 | 0 | 12 |
| TAGLN | MRVI1 | 0.837103 | 7 | 0 | 7 |
| TAGLN | PDLIM3 | 0.830571 | 12 | 0 | 11 |
| TAGLN | MYLK | 0.824505 | 12 | 0 | 12 |
| TAGLN | MSRB3 | 0.821975 | 7 | 0 | 7 |
| TAGLN | TMEM47 | 0.812244 | 12 | 0 | 11 |
| TAGLN | NEXN | 0.809315 | 8 | 0 | 8 |
| TAGLN | PLN | 0.805585 | 12 | 0 | 12 |
| TAGLN | AOC3 | 0.802469 | 12 | 0 | 11 |
| TAGLN | SMOC2 | 0.799869 | 5 | 0 | 5 |
| TAGLN | RBPMS2 | 0.789239 | 7 | 0 | 7 |
| TAGLN | DDR2 | 0.783119 | 11 | 0 | 11 |
| TAGLN | FILIP1 | 0.782114 | 5 | 0 | 5 |
| TAGLN | RASSF3 | 0.777718 | 4 | 0 | 4 |
| TAGLN | MYH11 | 0.776688 | 11 | 0 | 11 |
For details and further investigation, click here
