| Full name: CCR4-NOT transcription complex subunit 6 | Alias Symbol: CCR4|KIAA1194|Ccr4a | ||
| Type: protein-coding gene | Cytoband: 5q35.3 | ||
| Entrez ID: 57472 | HGNC ID: HGNC:14099 | Ensembl Gene: ENSG00000113300 | OMIM ID: 608951 |
| Drug and gene relationship at DGIdb | |||
Expression of CNOT6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CNOT6 | 57472 | 222476_at | -0.0018 | 0.9979 | |
| GSE20347 | CNOT6 | 57472 | 217970_s_at | -0.1895 | 0.2165 | |
| GSE23400 | CNOT6 | 57472 | 217970_s_at | 0.0751 | 0.2751 | |
| GSE26886 | CNOT6 | 57472 | 222476_at | -0.2109 | 0.4022 | |
| GSE29001 | CNOT6 | 57472 | 217970_s_at | -0.1148 | 0.6828 | |
| GSE38129 | CNOT6 | 57472 | 217970_s_at | 0.0301 | 0.8709 | |
| GSE45670 | CNOT6 | 57472 | 222476_at | -0.0564 | 0.7957 | |
| GSE53622 | CNOT6 | 57472 | 65926 | -0.1865 | 0.0128 | |
| GSE53624 | CNOT6 | 57472 | 65926 | -0.2185 | 0.0019 | |
| GSE63941 | CNOT6 | 57472 | 222476_at | 1.1787 | 0.0232 | |
| GSE77861 | CNOT6 | 57472 | 222476_at | -0.0254 | 0.9075 | |
| GSE97050 | CNOT6 | 57472 | A_24_P940125 | -0.1563 | 0.5167 | |
| SRP007169 | CNOT6 | 57472 | RNAseq | 0.4029 | 0.3774 | |
| SRP008496 | CNOT6 | 57472 | RNAseq | 0.2676 | 0.3352 | |
| SRP064894 | CNOT6 | 57472 | RNAseq | -0.1385 | 0.4781 | |
| SRP133303 | CNOT6 | 57472 | RNAseq | 0.4470 | 0.0465 | |
| SRP159526 | CNOT6 | 57472 | RNAseq | -0.1362 | 0.6222 | |
| SRP193095 | CNOT6 | 57472 | RNAseq | -0.0873 | 0.4478 | |
| SRP219564 | CNOT6 | 57472 | RNAseq | 0.1138 | 0.7698 | |
| TCGA | CNOT6 | 57472 | RNAseq | 0.0695 | 0.1757 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CNOT6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CNOT6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CNOT6 | 57472 | 2 | 12 | 16 | |
| GSE20123 | CNOT6 | 57472 | 2 | 12 | 16 | |
| GSE43470 | CNOT6 | 57472 | 1 | 10 | 32 | |
| GSE46452 | CNOT6 | 57472 | 0 | 27 | 32 | |
| GSE47630 | CNOT6 | 57472 | 1 | 20 | 19 | |
| GSE54993 | CNOT6 | 57472 | 10 | 2 | 58 | |
| GSE54994 | CNOT6 | 57472 | 3 | 18 | 32 | |
| GSE60625 | CNOT6 | 57472 | 1 | 0 | 10 | |
| GSE74703 | CNOT6 | 57472 | 1 | 6 | 29 | |
| GSE74704 | CNOT6 | 57472 | 1 | 6 | 13 | |
| TCGA | CNOT6 | 57472 | 12 | 34 | 50 |
Total number of gains: 34; Total number of losses: 147; Total Number of normals: 307.
Somatic mutations of CNOT6:
Generating mutation plots.
Highly correlated genes for CNOT6:
Showing top 20/313 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CNOT6 | TANC1 | 0.746863 | 3 | 0 | 3 |
| CNOT6 | RRAGC | 0.743954 | 3 | 0 | 3 |
| CNOT6 | PAIP2 | 0.73378 | 3 | 0 | 3 |
| CNOT6 | GPS2 | 0.727008 | 3 | 0 | 3 |
| CNOT6 | AKAP17A | 0.726393 | 3 | 0 | 3 |
| CNOT6 | UFC1 | 0.718993 | 3 | 0 | 3 |
| CNOT6 | KIN | 0.707095 | 4 | 0 | 3 |
| CNOT6 | ALAS1 | 0.706879 | 3 | 0 | 3 |
| CNOT6 | TRAP1 | 0.698801 | 3 | 0 | 3 |
| CNOT6 | TUBB2A | 0.694985 | 3 | 0 | 3 |
| CNOT6 | ZC3H15 | 0.689799 | 3 | 0 | 3 |
| CNOT6 | TOM1L1 | 0.683759 | 4 | 0 | 4 |
| CNOT6 | C1GALT1C1 | 0.677537 | 4 | 0 | 3 |
| CNOT6 | CBLL1 | 0.676916 | 4 | 0 | 3 |
| CNOT6 | CMC1 | 0.675918 | 4 | 0 | 3 |
| CNOT6 | APIP | 0.674879 | 4 | 0 | 4 |
| CNOT6 | BLCAP | 0.673804 | 3 | 0 | 3 |
| CNOT6 | CAPN7 | 0.671929 | 3 | 0 | 3 |
| CNOT6 | ZNF776 | 0.670381 | 3 | 0 | 3 |
| CNOT6 | NDUFB6 | 0.665457 | 3 | 0 | 3 |
For details and further investigation, click here
