| Full name: collagen type XVIII alpha 1 chain | Alias Symbol: KS|KNO1 | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 80781 | HGNC ID: HGNC:2195 | Ensembl Gene: ENSG00000182871 | OMIM ID: 120328 |
| Drug and gene relationship at DGIdb | |||
Expression of COL18A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COL18A1 | 80781 | 209081_s_at | 0.8712 | 0.3035 | |
| GSE20347 | COL18A1 | 80781 | 209082_s_at | 0.4215 | 0.0226 | |
| GSE23400 | COL18A1 | 80781 | 209081_s_at | 0.6650 | 0.0000 | |
| GSE26886 | COL18A1 | 80781 | 209082_s_at | 1.6064 | 0.0000 | |
| GSE29001 | COL18A1 | 80781 | 209082_s_at | 0.1266 | 0.5634 | |
| GSE38129 | COL18A1 | 80781 | 209082_s_at | 0.4713 | 0.0109 | |
| GSE45670 | COL18A1 | 80781 | 209081_s_at | -0.0136 | 0.9741 | |
| GSE53622 | COL18A1 | 80781 | 41926 | 0.5847 | 0.0000 | |
| GSE53624 | COL18A1 | 80781 | 41926 | 0.8430 | 0.0000 | |
| GSE63941 | COL18A1 | 80781 | 209081_s_at | -1.4026 | 0.0085 | |
| GSE77861 | COL18A1 | 80781 | 209081_s_at | 0.5846 | 0.0305 | |
| GSE97050 | COL18A1 | 80781 | A_23_P211212 | 0.4667 | 0.1378 | |
| SRP007169 | COL18A1 | 80781 | RNAseq | 1.5974 | 0.0017 | |
| SRP008496 | COL18A1 | 80781 | RNAseq | 1.6142 | 0.0000 | |
| SRP064894 | COL18A1 | 80781 | RNAseq | 1.1292 | 0.0000 | |
| SRP133303 | COL18A1 | 80781 | RNAseq | 0.5236 | 0.0249 | |
| SRP159526 | COL18A1 | 80781 | RNAseq | 0.7930 | 0.0099 | |
| SRP193095 | COL18A1 | 80781 | RNAseq | 1.5447 | 0.0000 | |
| SRP219564 | COL18A1 | 80781 | RNAseq | 0.9821 | 0.0153 | |
| TCGA | COL18A1 | 80781 | RNAseq | 0.1727 | 0.0110 |
Upregulated datasets: 5; Downregulated datasets: 1.
Survival by COL18A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COL18A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COL18A1 | 80781 | 2 | 9 | 19 | |
| GSE20123 | COL18A1 | 80781 | 2 | 8 | 20 | |
| GSE43470 | COL18A1 | 80781 | 0 | 14 | 29 | |
| GSE46452 | COL18A1 | 80781 | 1 | 21 | 37 | |
| GSE47630 | COL18A1 | 80781 | 6 | 17 | 17 | |
| GSE54993 | COL18A1 | 80781 | 8 | 1 | 61 | |
| GSE54994 | COL18A1 | 80781 | 5 | 8 | 40 | |
| GSE60625 | COL18A1 | 80781 | 0 | 0 | 11 | |
| GSE74703 | COL18A1 | 80781 | 0 | 10 | 26 | |
| GSE74704 | COL18A1 | 80781 | 1 | 4 | 15 | |
| TCGA | COL18A1 | 80781 | 9 | 38 | 49 |
Total number of gains: 34; Total number of losses: 130; Total Number of normals: 324.
Somatic mutations of COL18A1:
Generating mutation plots.
Highly correlated genes for COL18A1:
Showing top 20/1056 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COL18A1 | TTYH3 | 0.73858 | 7 | 0 | 7 |
| COL18A1 | COL5A1 | 0.722611 | 13 | 0 | 12 |
| COL18A1 | FAM3A | 0.718897 | 3 | 0 | 3 |
| COL18A1 | SCYL1 | 0.706705 | 4 | 0 | 3 |
| COL18A1 | NNMT | 0.704516 | 3 | 0 | 3 |
| COL18A1 | COL6A3 | 0.703258 | 13 | 0 | 12 |
| COL18A1 | PDGFRB | 0.701989 | 12 | 0 | 12 |
| COL18A1 | B3GNT9 | 0.694359 | 7 | 0 | 7 |
| COL18A1 | FBLIM1 | 0.692239 | 6 | 0 | 5 |
| COL18A1 | BGN | 0.686696 | 13 | 0 | 10 |
| COL18A1 | SPARC | 0.685254 | 12 | 0 | 11 |
| COL18A1 | FAM126A | 0.684491 | 3 | 0 | 3 |
| COL18A1 | LOXL2 | 0.681953 | 12 | 0 | 12 |
| COL18A1 | THY1 | 0.679105 | 13 | 0 | 12 |
| COL18A1 | SNHG22 | 0.678075 | 3 | 0 | 3 |
| COL18A1 | FN1 | 0.676654 | 11 | 0 | 10 |
| COL18A1 | GDF11 | 0.676063 | 3 | 0 | 3 |
| COL18A1 | BCAR1 | 0.674065 | 4 | 0 | 4 |
| COL18A1 | SPON2 | 0.673593 | 4 | 0 | 3 |
| COL18A1 | MMP2 | 0.673297 | 11 | 0 | 11 |
For details and further investigation, click here
