MMP2

 

Full name: matrix metallopeptidase 2 Alias Symbol: TBE-1
Type: protein-coding gene Cytoband: 16q12.2
Entrez ID: 4313 HGNC ID: HGNC:7166 Ensembl Gene: ENSG00000087245 OMIM ID: 120360
Drug and gene relationship at DGIdb

 

MMP2 involved pathways:

KEGG pathway Description View
hsa04670Leukocyte transendothelial migration
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer

 

Expression of MMP2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MMP2 4313 201069_at 0.4845 0.5840
GSE20347 MMP2 4313 201069_at 1.9777 0.0000
GSE23400 MMP2 4313 201069_at 0.9259 0.0000
GSE26886 MMP2 4313 201069_at 2.1257 0.0003
GSE29001 MMP2 4313 201069_at 0.9980 0.0126
GSE38129 MMP2 4313 201069_at 1.5885 0.0007
GSE45670 MMP2 4313 201069_at -0.0955 0.9064
GSE53622 MMP2 4313 37036 0.1391 0.0194
GSE53624 MMP2 4313 37036 -0.2526 0.0015
GSE63941 MMP2 4313 201069_at -6.3633 0.0001
GSE77861 MMP2 4313 201069_at 1.8658 0.0186
GSE97050 MMP2 4313 A_33_P3237135 1.3029 0.1761
SRP007169 MMP2 4313 RNAseq 4.9772 0.0000
SRP008496 MMP2 4313 RNAseq 5.2469 0.0000
SRP064894 MMP2 4313 RNAseq 2.3928 0.0000
SRP133303 MMP2 4313 RNAseq 2.1043 0.0000
SRP159526 MMP2 4313 RNAseq 1.5501 0.0035
SRP193095 MMP2 4313 RNAseq 3.1012 0.0000
SRP219564 MMP2 4313 RNAseq 1.9265 0.0172
TCGA MMP2 4313 RNAseq 0.0651 0.5440

Upregulated datasets: 11; Downregulated datasets: 1.  

 

Survival by MMP2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MMP2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MMP2 4313 3 0 27
GSE20123 MMP2 4313 3 0 27
GSE43470 MMP2 4313 2 7 34
GSE46452 MMP2 4313 38 1 20
GSE47630 MMP2 4313 10 8 22
GSE54993 MMP2 4313 2 4 64
GSE54994 MMP2 4313 7 10 36
GSE60625 MMP2 4313 4 0 7
GSE74703 MMP2 4313 2 4 30
GSE74704 MMP2 4313 3 0 17
TCGA MMP2 4313 25 12 59

Total number of gains: 99; Total number of losses: 46; Total Number of normals: 343.  

 

Somatic mutations of MMP2:

 

Generating mutation plots.

 

Highly correlated genes for MMP2:

 

Showing top 20/908 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MMP2COL6A30.83386612011
MMP2CTSK0.82226112011
MMP2SPARC0.81186312011
MMP2PCOLCE0.81063812011
MMP2VCAN0.80767112011
MMP2COL1A20.79539813013
MMP2COL12A10.791376807
MMP2PDGFRB0.79088112012
MMP2FAP0.78403511011
MMP2COL5A10.78372312011
MMP2COL6A10.78177512011
MMP2PLXND10.77415210010
MMP2FOSL10.773293303
MMP2COL5A20.77101112011
MMP2HTRA10.76657312011
MMP2FBN10.76636211011
MMP2COL3A10.76124812011
MMP2COL6A20.75925412011
MMP2AEBP10.7570212011
MMP2ANGPTL20.75655712010

For details and further investigation, click here