| Full name: collagen type XXI alpha 1 chain | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p12.1 | ||
| Entrez ID: 81578 | HGNC ID: HGNC:17025 | Ensembl Gene: ENSG00000124749 | OMIM ID: 610002 |
| Drug and gene relationship at DGIdb | |||
COL21A1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05205 | Proteoglycans in cancer |
Expression of COL21A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COL21A1 | 81578 | 208096_s_at | -1.1420 | 0.1848 | |
| GSE20347 | COL21A1 | 81578 | 208096_s_at | -0.4369 | 0.1409 | |
| GSE23400 | COL21A1 | 81578 | 208096_s_at | -0.3850 | 0.0019 | |
| GSE26886 | COL21A1 | 81578 | 208096_s_at | 0.1422 | 0.8705 | |
| GSE29001 | COL21A1 | 81578 | 208096_s_at | -0.5728 | 0.1630 | |
| GSE38129 | COL21A1 | 81578 | 208096_s_at | -0.6454 | 0.1174 | |
| GSE45670 | COL21A1 | 81578 | 208096_s_at | -1.5802 | 0.0044 | |
| GSE53622 | COL21A1 | 81578 | 32995 | 0.0597 | 0.6798 | |
| GSE53624 | COL21A1 | 81578 | 32995 | 0.4085 | 0.0001 | |
| GSE63941 | COL21A1 | 81578 | 208096_s_at | 0.2773 | 0.6401 | |
| GSE77861 | COL21A1 | 81578 | 208096_s_at | 0.8346 | 0.3042 | |
| GSE97050 | COL21A1 | 81578 | A_23_P31124 | -0.4060 | 0.4368 | |
| SRP064894 | COL21A1 | 81578 | RNAseq | 0.0474 | 0.9212 | |
| SRP133303 | COL21A1 | 81578 | RNAseq | -0.4383 | 0.2546 | |
| SRP159526 | COL21A1 | 81578 | RNAseq | -0.8399 | 0.1734 | |
| SRP193095 | COL21A1 | 81578 | RNAseq | 0.0174 | 0.9598 | |
| SRP219564 | COL21A1 | 81578 | RNAseq | -1.1923 | 0.1739 | |
| TCGA | COL21A1 | 81578 | RNAseq | -0.3671 | 0.3483 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by COL21A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COL21A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COL21A1 | 81578 | 9 | 1 | 20 | |
| GSE20123 | COL21A1 | 81578 | 9 | 1 | 20 | |
| GSE43470 | COL21A1 | 81578 | 5 | 0 | 38 | |
| GSE46452 | COL21A1 | 81578 | 2 | 10 | 47 | |
| GSE47630 | COL21A1 | 81578 | 7 | 5 | 28 | |
| GSE54993 | COL21A1 | 81578 | 3 | 2 | 65 | |
| GSE54994 | COL21A1 | 81578 | 9 | 4 | 40 | |
| GSE60625 | COL21A1 | 81578 | 0 | 1 | 10 | |
| GSE74703 | COL21A1 | 81578 | 5 | 0 | 31 | |
| GSE74704 | COL21A1 | 81578 | 5 | 0 | 15 | |
| TCGA | COL21A1 | 81578 | 23 | 11 | 62 |
Total number of gains: 77; Total number of losses: 35; Total Number of normals: 376.
Somatic mutations of COL21A1:
Generating mutation plots.
Highly correlated genes for COL21A1:
Showing top 20/479 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COL21A1 | PLEKHH2 | 0.758949 | 3 | 0 | 3 |
| COL21A1 | RGS7BP | 0.739745 | 3 | 0 | 3 |
| COL21A1 | PLEKHB1 | 0.732394 | 4 | 0 | 4 |
| COL21A1 | CEP112 | 0.727649 | 4 | 0 | 4 |
| COL21A1 | GFRA1 | 0.717471 | 3 | 0 | 3 |
| COL21A1 | FNIP2 | 0.709233 | 3 | 0 | 3 |
| COL21A1 | NFASC | 0.706503 | 4 | 0 | 4 |
| COL21A1 | C1QTNF7 | 0.705961 | 3 | 0 | 3 |
| COL21A1 | NFIX | 0.695747 | 3 | 0 | 3 |
| COL21A1 | CCDC69 | 0.691063 | 5 | 0 | 5 |
| COL21A1 | BHMT2 | 0.686616 | 5 | 0 | 5 |
| COL21A1 | CASKIN2 | 0.681678 | 3 | 0 | 3 |
| COL21A1 | KLHDC1 | 0.681619 | 3 | 0 | 3 |
| COL21A1 | NEGR1 | 0.679514 | 3 | 0 | 3 |
| COL21A1 | FOXP2 | 0.678535 | 3 | 0 | 3 |
| COL21A1 | RHOU | 0.67746 | 4 | 0 | 3 |
| COL21A1 | HOXA4 | 0.673743 | 5 | 0 | 4 |
| COL21A1 | RAB9B | 0.667408 | 3 | 0 | 3 |
| COL21A1 | SMAD5 | 0.66595 | 3 | 0 | 3 |
| COL21A1 | ANGPTL1 | 0.665871 | 3 | 0 | 3 |
For details and further investigation, click here
