| Full name: PEST proteolytic signal containing nuclear protein | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q12.3 | ||
| Entrez ID: 57092 | HGNC ID: HGNC:30023 | Ensembl Gene: ENSG00000081154 | OMIM ID: 615210 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PCNP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCNP | 57092 | 217816_s_at | -0.3608 | 0.2708 | |
| GSE20347 | PCNP | 57092 | 217816_s_at | 0.0399 | 0.7994 | |
| GSE23400 | PCNP | 57092 | 217816_s_at | 0.1126 | 0.1555 | |
| GSE26886 | PCNP | 57092 | 217816_s_at | 0.2969 | 0.0667 | |
| GSE29001 | PCNP | 57092 | 217816_s_at | 0.0607 | 0.9052 | |
| GSE38129 | PCNP | 57092 | 217816_s_at | -0.0783 | 0.5028 | |
| GSE45670 | PCNP | 57092 | 217816_s_at | -0.2843 | 0.0152 | |
| GSE53622 | PCNP | 57092 | 92990 | -0.2966 | 0.0000 | |
| GSE53624 | PCNP | 57092 | 31488 | -0.0205 | 0.6649 | |
| GSE63941 | PCNP | 57092 | 217816_s_at | -0.6586 | 0.1200 | |
| GSE77861 | PCNP | 57092 | 217816_s_at | -0.1000 | 0.5949 | |
| GSE97050 | PCNP | 57092 | A_23_P155332 | 0.1117 | 0.7166 | |
| SRP007169 | PCNP | 57092 | RNAseq | 0.5016 | 0.2928 | |
| SRP008496 | PCNP | 57092 | RNAseq | 0.9875 | 0.0007 | |
| SRP064894 | PCNP | 57092 | RNAseq | -0.1661 | 0.3377 | |
| SRP133303 | PCNP | 57092 | RNAseq | 0.1873 | 0.1874 | |
| SRP159526 | PCNP | 57092 | RNAseq | 0.0971 | 0.5279 | |
| SRP193095 | PCNP | 57092 | RNAseq | -0.0477 | 0.5818 | |
| SRP219564 | PCNP | 57092 | RNAseq | -0.1566 | 0.5574 | |
| TCGA | PCNP | 57092 | RNAseq | -0.0001 | 0.9977 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PCNP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PCNP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCNP | 57092 | 18 | 1 | 11 | |
| GSE20123 | PCNP | 57092 | 17 | 1 | 12 | |
| GSE43470 | PCNP | 57092 | 17 | 1 | 25 | |
| GSE46452 | PCNP | 57092 | 12 | 6 | 41 | |
| GSE47630 | PCNP | 57092 | 16 | 6 | 18 | |
| GSE54993 | PCNP | 57092 | 2 | 5 | 63 | |
| GSE54994 | PCNP | 57092 | 27 | 5 | 21 | |
| GSE60625 | PCNP | 57092 | 0 | 6 | 5 | |
| GSE74703 | PCNP | 57092 | 14 | 1 | 21 | |
| GSE74704 | PCNP | 57092 | 14 | 1 | 5 | |
| TCGA | PCNP | 57092 | 48 | 9 | 39 |
Total number of gains: 185; Total number of losses: 42; Total Number of normals: 261.
Somatic mutations of PCNP:
Generating mutation plots.
Highly correlated genes for PCNP:
Showing top 20/668 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCNP | KLHL5 | 0.756944 | 3 | 0 | 3 |
| PCNP | CCNB1IP1 | 0.755968 | 3 | 0 | 3 |
| PCNP | FBXO28 | 0.751306 | 3 | 0 | 3 |
| PCNP | C1GALT1C1 | 0.736699 | 4 | 0 | 4 |
| PCNP | NDUFAF2 | 0.730514 | 3 | 0 | 3 |
| PCNP | KLHL7 | 0.727864 | 3 | 0 | 3 |
| PCNP | HAGH | 0.721035 | 3 | 0 | 3 |
| PCNP | PARP8 | 0.721011 | 3 | 0 | 3 |
| PCNP | ZBTB26 | 0.719557 | 5 | 0 | 5 |
| PCNP | ERRFI1 | 0.715946 | 3 | 0 | 3 |
| PCNP | MED7 | 0.715328 | 5 | 0 | 4 |
| PCNP | ATP6V1G1 | 0.71531 | 3 | 0 | 3 |
| PCNP | COPS5 | 0.714825 | 3 | 0 | 3 |
| PCNP | YY1 | 0.713127 | 3 | 0 | 3 |
| PCNP | GALM | 0.709587 | 3 | 0 | 3 |
| PCNP | TIMM9 | 0.709407 | 3 | 0 | 3 |
| PCNP | RPF1 | 0.708648 | 3 | 0 | 3 |
| PCNP | TAF12 | 0.70357 | 3 | 0 | 3 |
| PCNP | CD164 | 0.701517 | 9 | 0 | 9 |
| PCNP | IRAK3 | 0.698774 | 3 | 0 | 3 |
For details and further investigation, click here
