| Full name: COP9 signalosome subunit 8 | Alias Symbol: COP9|CSN8|MGC1297|SGN8 | ||
| Type: protein-coding gene | Cytoband: 2q37.3 | ||
| Entrez ID: 10920 | HGNC ID: HGNC:24335 | Ensembl Gene: ENSG00000198612 | OMIM ID: 616011 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COPS8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COPS8 | 10920 | 202141_s_at | 0.5397 | 0.6255 | |
| GSE20347 | COPS8 | 10920 | 202141_s_at | 0.3915 | 0.0246 | |
| GSE23400 | COPS8 | 10920 | 202141_s_at | 0.4683 | 0.0000 | |
| GSE26886 | COPS8 | 10920 | 202141_s_at | 0.6185 | 0.0233 | |
| GSE29001 | COPS8 | 10920 | 202141_s_at | 0.5331 | 0.1017 | |
| GSE38129 | COPS8 | 10920 | 202141_s_at | 0.3467 | 0.0287 | |
| GSE45670 | COPS8 | 10920 | 202141_s_at | 0.1491 | 0.3748 | |
| GSE53622 | COPS8 | 10920 | 102220 | -0.1882 | 0.1723 | |
| GSE53624 | COPS8 | 10920 | 102220 | 0.4485 | 0.0026 | |
| GSE63941 | COPS8 | 10920 | 202141_s_at | -1.0636 | 0.0035 | |
| GSE77861 | COPS8 | 10920 | 202141_s_at | 0.6068 | 0.0052 | |
| GSE97050 | COPS8 | 10920 | A_33_P3289145 | 0.2991 | 0.2801 | |
| SRP007169 | COPS8 | 10920 | RNAseq | 1.0353 | 0.0021 | |
| SRP008496 | COPS8 | 10920 | RNAseq | 0.6974 | 0.0006 | |
| SRP064894 | COPS8 | 10920 | RNAseq | 0.6232 | 0.0000 | |
| SRP133303 | COPS8 | 10920 | RNAseq | 0.6953 | 0.0000 | |
| SRP159526 | COPS8 | 10920 | RNAseq | 0.4417 | 0.0072 | |
| SRP193095 | COPS8 | 10920 | RNAseq | 0.3297 | 0.0084 | |
| SRP219564 | COPS8 | 10920 | RNAseq | 0.5726 | 0.1159 | |
| TCGA | COPS8 | 10920 | RNAseq | 0.0261 | 0.5927 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by COPS8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COPS8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COPS8 | 10920 | 1 | 11 | 18 | |
| GSE20123 | COPS8 | 10920 | 1 | 11 | 18 | |
| GSE43470 | COPS8 | 10920 | 1 | 9 | 33 | |
| GSE46452 | COPS8 | 10920 | 0 | 5 | 54 | |
| GSE47630 | COPS8 | 10920 | 4 | 5 | 31 | |
| GSE54993 | COPS8 | 10920 | 3 | 2 | 65 | |
| GSE54994 | COPS8 | 10920 | 8 | 10 | 35 | |
| GSE60625 | COPS8 | 10920 | 0 | 3 | 8 | |
| GSE74703 | COPS8 | 10920 | 1 | 7 | 28 | |
| GSE74704 | COPS8 | 10920 | 1 | 5 | 14 | |
| TCGA | COPS8 | 10920 | 11 | 27 | 58 |
Total number of gains: 31; Total number of losses: 95; Total Number of normals: 362.
Somatic mutations of COPS8:
Generating mutation plots.
Highly correlated genes for COPS8:
Showing top 20/1167 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COPS8 | C6orf141 | 0.7721 | 3 | 0 | 3 |
| COPS8 | PDE8A | 0.760963 | 4 | 0 | 4 |
| COPS8 | SLC15A4 | 0.737247 | 5 | 0 | 5 |
| COPS8 | NINJ1 | 0.721741 | 4 | 0 | 4 |
| COPS8 | CDKN1A | 0.721284 | 3 | 0 | 3 |
| COPS8 | RPRD1A | 0.717037 | 3 | 0 | 3 |
| COPS8 | SULF2 | 0.705103 | 3 | 0 | 3 |
| COPS8 | WDFY1 | 0.703025 | 3 | 0 | 3 |
| COPS8 | DTYMK | 0.702441 | 8 | 0 | 7 |
| COPS8 | CCNT1 | 0.70141 | 3 | 0 | 3 |
| COPS8 | AMMECR1L | 0.700129 | 5 | 0 | 5 |
| COPS8 | GLIS3 | 0.696622 | 4 | 0 | 3 |
| COPS8 | SUN1 | 0.694807 | 3 | 0 | 3 |
| COPS8 | FLNB | 0.694055 | 4 | 0 | 3 |
| COPS8 | NACC1 | 0.692775 | 3 | 0 | 3 |
| COPS8 | DTD2 | 0.692527 | 3 | 0 | 3 |
| COPS8 | SH3BP4 | 0.690551 | 11 | 0 | 10 |
| COPS8 | SLIRP | 0.689629 | 3 | 0 | 3 |
| COPS8 | SCMH1 | 0.688846 | 4 | 0 | 4 |
| COPS8 | NDUFA12 | 0.688225 | 3 | 0 | 3 |
For details and further investigation, click here
