CDKN1A

 

Full name: cyclin dependent kinase inhibitor 1A Alias Symbol: P21|CIP1|WAF1|SDI1|CAP20|p21CIP1|p21Cip1/Waf1|p21
Type: protein-coding gene Cytoband: 6p21.2
Entrez ID: 1026 HGNC ID: HGNC:1784 Ensembl Gene: ENSG00000124762 OMIM ID: 116899
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CDKN1A involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04921Oxytocin signaling pathway
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia

 

Expression of CDKN1A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDKN1A 1026 202284_s_at -0.2087 0.7538
GSE20347 CDKN1A 1026 202284_s_at -0.1011 0.6704
GSE23400 CDKN1A 1026 202284_s_at -0.0576 0.6351
GSE26886 CDKN1A 1026 202284_s_at 0.0672 0.8853
GSE29001 CDKN1A 1026 202284_s_at 0.0625 0.8904
GSE38129 CDKN1A 1026 202284_s_at -0.0534 0.8427
GSE45670 CDKN1A 1026 202284_s_at 0.4217 0.1499
GSE53622 CDKN1A 1026 22556 -0.2582 0.1006
GSE53624 CDKN1A 1026 29826 0.0086 0.9416
GSE63941 CDKN1A 1026 202284_s_at -2.6991 0.0010
GSE77861 CDKN1A 1026 202284_s_at 0.2679 0.4561
GSE97050 CDKN1A 1026 A_24_P89457 0.1103 0.8548
SRP007169 CDKN1A 1026 RNAseq -0.8054 0.0127
SRP008496 CDKN1A 1026 RNAseq -0.4692 0.0176
SRP064894 CDKN1A 1026 RNAseq -0.2275 0.4703
SRP133303 CDKN1A 1026 RNAseq 0.3436 0.2284
SRP159526 CDKN1A 1026 RNAseq -0.4514 0.3436
SRP193095 CDKN1A 1026 RNAseq 0.1508 0.4912
SRP219564 CDKN1A 1026 RNAseq -0.8675 0.1674
TCGA CDKN1A 1026 RNAseq -0.0886 0.2969

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by CDKN1A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CDKN1A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDKN1A 1026 6 0 24
GSE20123 CDKN1A 1026 6 0 24
GSE43470 CDKN1A 1026 5 1 37
GSE46452 CDKN1A 1026 2 9 48
GSE47630 CDKN1A 1026 8 4 28
GSE54993 CDKN1A 1026 3 1 66
GSE54994 CDKN1A 1026 10 5 38
GSE60625 CDKN1A 1026 1 0 10
GSE74703 CDKN1A 1026 5 0 31
GSE74704 CDKN1A 1026 3 0 17
TCGA CDKN1A 1026 15 15 66

Total number of gains: 64; Total number of losses: 35; Total Number of normals: 389.  

 

Somatic mutations of CDKN1A:

 

Generating mutation plots.

 

Highly correlated genes for CDKN1A:

 

Showing top 20/144 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDKN1ACOPS80.721284303
CDKN1AOLFML30.707628303
CDKN1ATNFRSF10B0.662486303
CDKN1ACOPZ20.659549303
CDKN1ACHRM20.649006403
CDKN1AST3GAL20.64038303
CDKN1APLEKHM30.634357303
CDKN1AASPN0.632674303
CDKN1APEX190.628157303
CDKN1AGRIN3A0.625253303
CDKN1AGADD45B0.623539503
CDKN1ASGIP10.623266303
CDKN1ALACTB0.622374303
CDKN1AC9orf470.62126303
CDKN1AFOSL10.61603611010
CDKN1AGIPC30.612822303
CDKN1AWFDC10.611835303
CDKN1ABICC10.608864403
CDKN1ALATS20.607006403
CDKN1ASERTAD10.603889706

For details and further investigation, click here