| Full name: cytochrome c oxidase subunit 6A1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 1337 | HGNC ID: HGNC:2277 | Ensembl Gene: ENSG00000111775 | OMIM ID: 602072 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of COX6A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COX6A1 | 1337 | 200925_at | 0.1300 | 0.7188 | |
| GSE20347 | COX6A1 | 1337 | 200925_at | -0.0930 | 0.5218 | |
| GSE23400 | COX6A1 | 1337 | 200925_at | -0.0349 | 0.5852 | |
| GSE26886 | COX6A1 | 1337 | 200925_at | 0.5441 | 0.0035 | |
| GSE29001 | COX6A1 | 1337 | 200925_at | -0.2897 | 0.1726 | |
| GSE38129 | COX6A1 | 1337 | 200925_at | -0.0113 | 0.9268 | |
| GSE45670 | COX6A1 | 1337 | 200925_at | 0.0015 | 0.9915 | |
| GSE53622 | COX6A1 | 1337 | 3999 | -0.3752 | 0.0000 | |
| GSE53624 | COX6A1 | 1337 | 3999 | 0.0408 | 0.4057 | |
| GSE63941 | COX6A1 | 1337 | 200925_at | 0.4740 | 0.0566 | |
| GSE77861 | COX6A1 | 1337 | 200925_at | -0.0534 | 0.7933 | |
| GSE97050 | COX6A1 | 1337 | A_32_P168247 | -0.5498 | 0.1538 | |
| SRP007169 | COX6A1 | 1337 | RNAseq | -0.9164 | 0.0072 | |
| SRP008496 | COX6A1 | 1337 | RNAseq | -1.0031 | 0.0000 | |
| SRP064894 | COX6A1 | 1337 | RNAseq | -0.1607 | 0.5705 | |
| SRP133303 | COX6A1 | 1337 | RNAseq | -0.0360 | 0.8037 | |
| SRP159526 | COX6A1 | 1337 | RNAseq | 0.0029 | 0.9877 | |
| SRP193095 | COX6A1 | 1337 | RNAseq | -0.6871 | 0.0000 | |
| SRP219564 | COX6A1 | 1337 | RNAseq | -0.3091 | 0.3075 | |
| TCGA | COX6A1 | 1337 | RNAseq | -0.0250 | 0.6417 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by COX6A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COX6A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COX6A1 | 1337 | 6 | 2 | 22 | |
| GSE20123 | COX6A1 | 1337 | 6 | 2 | 22 | |
| GSE43470 | COX6A1 | 1337 | 2 | 2 | 39 | |
| GSE46452 | COX6A1 | 1337 | 9 | 1 | 49 | |
| GSE47630 | COX6A1 | 1337 | 9 | 3 | 28 | |
| GSE54993 | COX6A1 | 1337 | 0 | 5 | 65 | |
| GSE54994 | COX6A1 | 1337 | 7 | 6 | 40 | |
| GSE60625 | COX6A1 | 1337 | 0 | 0 | 11 | |
| GSE74703 | COX6A1 | 1337 | 2 | 1 | 33 | |
| GSE74704 | COX6A1 | 1337 | 3 | 2 | 15 | |
| TCGA | COX6A1 | 1337 | 21 | 10 | 65 |
Total number of gains: 65; Total number of losses: 34; Total Number of normals: 389.
Somatic mutations of COX6A1:
Generating mutation plots.
Highly correlated genes for COX6A1:
Showing top 20/378 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COX6A1 | LUC7L2 | 0.767218 | 3 | 0 | 3 |
| COX6A1 | SRI | 0.728632 | 3 | 0 | 3 |
| COX6A1 | SLC38A1 | 0.727447 | 3 | 0 | 3 |
| COX6A1 | PAGR1 | 0.716803 | 3 | 0 | 3 |
| COX6A1 | RAD23A | 0.716145 | 3 | 0 | 3 |
| COX6A1 | RPL37A | 0.70192 | 3 | 0 | 3 |
| COX6A1 | COMMD4 | 0.691338 | 3 | 0 | 3 |
| COX6A1 | MRPL51 | 0.690895 | 4 | 0 | 4 |
| COX6A1 | CBY1 | 0.676173 | 3 | 0 | 3 |
| COX6A1 | DHRS4L2 | 0.670055 | 3 | 0 | 3 |
| COX6A1 | ARHGEF39 | 0.668312 | 3 | 0 | 3 |
| COX6A1 | STAT6 | 0.66819 | 3 | 0 | 3 |
| COX6A1 | CNOT7 | 0.666514 | 3 | 0 | 3 |
| COX6A1 | RNF7 | 0.666316 | 3 | 0 | 3 |
| COX6A1 | ZBTB44 | 0.665543 | 3 | 0 | 3 |
| COX6A1 | BRCA1 | 0.662958 | 3 | 0 | 3 |
| COX6A1 | C12orf60 | 0.661687 | 3 | 0 | 3 |
| COX6A1 | CHCHD1 | 0.659762 | 5 | 0 | 5 |
| COX6A1 | REPIN1 | 0.657556 | 3 | 0 | 3 |
| COX6A1 | UBIAD1 | 0.657279 | 3 | 0 | 3 |
For details and further investigation, click here
