| Full name: signal transducer and activator of transcription 6 | Alias Symbol: D12S1644|IL-4-STAT | ||
| Type: protein-coding gene | Cytoband: 12q13 | ||
| Entrez ID: 6778 | HGNC ID: HGNC:11368 | Ensembl Gene: ENSG00000166888 | OMIM ID: 601512 |
| Drug and gene relationship at DGIdb | |||
STAT6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway | |
| hsa05161 | Hepatitis B | |
| hsa05321 | Inflammatory bowel disease (IBD) |
Expression of STAT6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STAT6 | 6778 | 201331_s_at | -0.0728 | 0.8770 | |
| GSE20347 | STAT6 | 6778 | 201331_s_at | -0.2199 | 0.0987 | |
| GSE23400 | STAT6 | 6778 | 201331_s_at | -0.0593 | 0.4701 | |
| GSE26886 | STAT6 | 6778 | 201331_s_at | 0.0698 | 0.6988 | |
| GSE29001 | STAT6 | 6778 | 201331_s_at | -0.0810 | 0.7595 | |
| GSE38129 | STAT6 | 6778 | 201331_s_at | -0.2298 | 0.0550 | |
| GSE45670 | STAT6 | 6778 | 201331_s_at | 0.0462 | 0.7618 | |
| GSE53622 | STAT6 | 6778 | 70444 | -0.4846 | 0.0000 | |
| GSE53624 | STAT6 | 6778 | 70444 | -0.3363 | 0.0000 | |
| GSE63941 | STAT6 | 6778 | 201331_s_at | -0.8617 | 0.0862 | |
| GSE77861 | STAT6 | 6778 | 201331_s_at | 0.1150 | 0.6592 | |
| GSE97050 | STAT6 | 6778 | A_23_P47879 | -0.3162 | 0.1801 | |
| SRP007169 | STAT6 | 6778 | RNAseq | -0.9506 | 0.0130 | |
| SRP008496 | STAT6 | 6778 | RNAseq | -0.8842 | 0.0000 | |
| SRP064894 | STAT6 | 6778 | RNAseq | -0.0338 | 0.7963 | |
| SRP133303 | STAT6 | 6778 | RNAseq | -0.2171 | 0.1151 | |
| SRP159526 | STAT6 | 6778 | RNAseq | -0.8960 | 0.0254 | |
| SRP193095 | STAT6 | 6778 | RNAseq | -0.0382 | 0.6687 | |
| SRP219564 | STAT6 | 6778 | RNAseq | -0.4714 | 0.0452 | |
| TCGA | STAT6 | 6778 | RNAseq | -0.0806 | 0.0523 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by STAT6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STAT6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STAT6 | 6778 | 7 | 1 | 22 | |
| GSE20123 | STAT6 | 6778 | 7 | 0 | 23 | |
| GSE43470 | STAT6 | 6778 | 3 | 0 | 40 | |
| GSE46452 | STAT6 | 6778 | 8 | 1 | 50 | |
| GSE47630 | STAT6 | 6778 | 10 | 2 | 28 | |
| GSE54993 | STAT6 | 6778 | 0 | 5 | 65 | |
| GSE54994 | STAT6 | 6778 | 4 | 1 | 48 | |
| GSE60625 | STAT6 | 6778 | 0 | 0 | 11 | |
| GSE74703 | STAT6 | 6778 | 3 | 0 | 33 | |
| GSE74704 | STAT6 | 6778 | 4 | 0 | 16 | |
| TCGA | STAT6 | 6778 | 14 | 10 | 72 |
Total number of gains: 60; Total number of losses: 20; Total Number of normals: 408.
Somatic mutations of STAT6:
Generating mutation plots.
Highly correlated genes for STAT6:
Showing top 20/299 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STAT6 | SSNA1 | 0.817239 | 3 | 0 | 3 |
| STAT6 | REPS1 | 0.794823 | 3 | 0 | 3 |
| STAT6 | AKT1S1 | 0.788818 | 3 | 0 | 3 |
| STAT6 | MMP15 | 0.770318 | 3 | 0 | 3 |
| STAT6 | SMO | 0.760313 | 3 | 0 | 3 |
| STAT6 | ECSIT | 0.731698 | 3 | 0 | 3 |
| STAT6 | ZNF800 | 0.715847 | 3 | 0 | 3 |
| STAT6 | SHISA5 | 0.713622 | 3 | 0 | 3 |
| STAT6 | ZBTB44 | 0.712561 | 4 | 0 | 4 |
| STAT6 | DEPDC5 | 0.702085 | 3 | 0 | 3 |
| STAT6 | ANKRD13A | 0.701098 | 3 | 0 | 3 |
| STAT6 | MED13 | 0.698876 | 3 | 0 | 3 |
| STAT6 | HGS | 0.69814 | 3 | 0 | 3 |
| STAT6 | PREX1 | 0.69293 | 3 | 0 | 3 |
| STAT6 | COMTD1 | 0.69203 | 3 | 0 | 3 |
| STAT6 | SOX13 | 0.687925 | 4 | 0 | 4 |
| STAT6 | POLR2A | 0.687082 | 4 | 0 | 4 |
| STAT6 | PTDSS2 | 0.68101 | 5 | 0 | 4 |
| STAT6 | RFNG | 0.68084 | 4 | 0 | 4 |
| STAT6 | TRIM56 | 0.676716 | 3 | 0 | 3 |
For details and further investigation, click here
