| Full name: COMM domain containing 4 | Alias Symbol: FLJ20452 | ||
| Type: protein-coding gene | Cytoband: 15q24.2 | ||
| Entrez ID: 54939 | HGNC ID: HGNC:26027 | Ensembl Gene: ENSG00000140365 | OMIM ID: 616701 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COMMD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COMMD4 | 54939 | 206441_s_at | 0.4307 | 0.2758 | |
| GSE20347 | COMMD4 | 54939 | 206441_s_at | 0.4489 | 0.0020 | |
| GSE23400 | COMMD4 | 54939 | 209132_s_at | 0.3914 | 0.0000 | |
| GSE26886 | COMMD4 | 54939 | 209132_s_at | 0.3476 | 0.1539 | |
| GSE29001 | COMMD4 | 54939 | 206441_s_at | 0.5220 | 0.0161 | |
| GSE38129 | COMMD4 | 54939 | 206441_s_at | 0.6107 | 0.0000 | |
| GSE45670 | COMMD4 | 54939 | 206441_s_at | 0.4540 | 0.0013 | |
| GSE53622 | COMMD4 | 54939 | 135623 | 0.1577 | 0.0156 | |
| GSE53624 | COMMD4 | 54939 | 135623 | 0.6385 | 0.0000 | |
| GSE63941 | COMMD4 | 54939 | 206441_s_at | 0.5262 | 0.2880 | |
| GSE77861 | COMMD4 | 54939 | 209132_s_at | 0.2212 | 0.2406 | |
| GSE97050 | COMMD4 | 54939 | A_24_P331904 | -0.3575 | 0.4587 | |
| SRP007169 | COMMD4 | 54939 | RNAseq | 0.2469 | 0.5262 | |
| SRP008496 | COMMD4 | 54939 | RNAseq | 0.0231 | 0.9290 | |
| SRP064894 | COMMD4 | 54939 | RNAseq | 1.2058 | 0.0003 | |
| SRP133303 | COMMD4 | 54939 | RNAseq | 0.6171 | 0.0012 | |
| SRP159526 | COMMD4 | 54939 | RNAseq | 0.9992 | 0.0004 | |
| SRP193095 | COMMD4 | 54939 | RNAseq | 0.3834 | 0.0003 | |
| SRP219564 | COMMD4 | 54939 | RNAseq | 0.8763 | 0.0569 | |
| TCGA | COMMD4 | 54939 | RNAseq | 0.1875 | 0.0005 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by COMMD4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COMMD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COMMD4 | 54939 | 8 | 1 | 21 | |
| GSE20123 | COMMD4 | 54939 | 8 | 1 | 21 | |
| GSE43470 | COMMD4 | 54939 | 4 | 6 | 33 | |
| GSE46452 | COMMD4 | 54939 | 3 | 7 | 49 | |
| GSE47630 | COMMD4 | 54939 | 8 | 10 | 22 | |
| GSE54993 | COMMD4 | 54939 | 5 | 6 | 59 | |
| GSE54994 | COMMD4 | 54939 | 5 | 6 | 42 | |
| GSE60625 | COMMD4 | 54939 | 4 | 0 | 7 | |
| GSE74703 | COMMD4 | 54939 | 4 | 3 | 29 | |
| GSE74704 | COMMD4 | 54939 | 4 | 1 | 15 | |
| TCGA | COMMD4 | 54939 | 14 | 15 | 67 |
Total number of gains: 67; Total number of losses: 56; Total Number of normals: 365.
Somatic mutations of COMMD4:
Generating mutation plots.
Highly correlated genes for COMMD4:
Showing top 20/1359 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COMMD4 | ALG10 | 0.748929 | 4 | 0 | 4 |
| COMMD4 | SFT2D3 | 0.723008 | 3 | 0 | 3 |
| COMMD4 | TTC39C | 0.708971 | 3 | 0 | 3 |
| COMMD4 | LETM2 | 0.707847 | 3 | 0 | 3 |
| COMMD4 | TET1 | 0.699901 | 3 | 0 | 3 |
| COMMD4 | COX6A1 | 0.691338 | 3 | 0 | 3 |
| COMMD4 | TMEM107 | 0.690089 | 3 | 0 | 3 |
| COMMD4 | MRPL38 | 0.686023 | 5 | 0 | 4 |
| COMMD4 | MAGOHB | 0.682636 | 7 | 0 | 6 |
| COMMD4 | C12orf45 | 0.680528 | 4 | 0 | 4 |
| COMMD4 | MRPS34 | 0.679442 | 11 | 0 | 10 |
| COMMD4 | FUS | 0.673825 | 9 | 0 | 9 |
| COMMD4 | SENP3 | 0.672966 | 9 | 0 | 8 |
| COMMD4 | GAS2L1 | 0.669056 | 3 | 0 | 3 |
| COMMD4 | RCN2 | 0.668997 | 7 | 0 | 6 |
| COMMD4 | CHMP7 | 0.666933 | 4 | 0 | 3 |
| COMMD4 | ALG1 | 0.665794 | 4 | 0 | 4 |
| COMMD4 | COPRS | 0.665649 | 3 | 0 | 3 |
| COMMD4 | BOLA3 | 0.664506 | 5 | 0 | 5 |
| COMMD4 | BRI3 | 0.664244 | 4 | 0 | 3 |
For details and further investigation, click here
